Translational Research Activities in Neuropsychiatry (TRAIN) - Renewal - 1

神经精神病学转化研究活动 (TRAIN) - 更新 - 1

• 批准号: 10171037
• 负责人: MADHUKAR H. TRIVEDI
• 金额: $ 21.59万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-10 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10171037
• 关键词: Adaptive Behaviors; Adoption; Area; Biological; Biological Markers; Clinical; Clinical Research; Cognition; Communities; Coupled; Cultural Diversity; Detection; Development; Diagnosis; Disease; Doctor of Philosophy; Electroencephalography; Epigenetic Process; Etiology; Faculty; Foundations; Functional disorder; Funding; Genetic; Genetic Research; Goals; Individual; Infrastructure; Knowledge; Lead; Leadership; Mental Health; Mental disorders; Mentors; National Institute of Mental Health; Neurobiology; Neurosciences; Neurosciences Research; Outcome; Physicians; Population; Precision therapeutics; Prevention; Process; Productivity; Proteomics; Psychiatric therapeutic procedure; Psychiatry; Research; Research Activity; Research Domain Criteria; Research Personnel; Research Project Grants; Research Training; Residencies; Resources; Rural; Science; Scientist; Self Care; Solid; Structure; Target Populations; Techniques; Technology; Time; Training; Training Programs; Translating; Translational Research; Translations; Work; Youth; addiction; base; biomarker evaluation; burnout; career; clinical care; design; improved; innovation; leadership development; medical schools; neuroimaging; neuropsychiatry; next generation; novel; optimism; personalized medicine; precision medicine; prevent; programs; prospective; resilience; skill acquisition; skills; tool; translational scientist; treatment optimization; treatment response

PROJECT SUMMARY Rapid developments in neuroscientific approaches, technologies, and analytics to understand the pathophysiology and treatment of mental illnesses have resulted in major advances that serve as a strong base toward the translation of cutting-edge research into personalized treatments for psychiatric conditions. In order to best leverage these advances, it is imperative that the next generation of researchers in psychiatry receive focused training that integrates translational research with clinical training. Psychiatric training programs that provide this focus, in conjunction with dedicated research time, and leadership and related skill development, are greatly needed. While there is concern in the field of a profound shortage of physician- scientists being trained, there is also reason for optimism, in that the number of MD/PhD medical school graduates applying for psychiatric residencies has increased. Our clinical and translational research training program, Translational Research Activities In Neuropsychiatry (TRAIN) is designed to provide exceptional training and mentoring to psychiatry residents with the express goal of generating clinical and translational researchers in psychiatry who will go on to become independent physician-scientists. This program focuses on the relationship between disruptions in underlying genetics and neurobiology and how they relate to adaptive behavior, as in the NIMH Research Domain Criteria (RDoC) framework, as well as the emergence of biomarkers that can inform clinical care. The TRAIN program harnesses the expertise and processes our faculty employ to bridge existing gaps in the field. This includes focused work and expertise in critical content areas, populations, and settings, as well as the use of approaches that span all ranges of translational science from the bench to the community. Our structured program provides an exceptional mentoring plan with experiential opportunities to participating residents coupled with timely didactics. The TRAIN program is specifically designed to train the next generation of researchers so that they can translate neuroscience and genetics research into advancements of our understanding of a wide range of mental health problems and treatments. TRAIN facilitates team science mentoring and training that is needed for translational research, with an emphasis on productivity through the conduct of a mentored research project, as well as deliverables such as networking and development of funding proposals to equip trainees for their next steps in training and academic research. TRAIN also focuses on wellness and guarding against burnout to encourage early adoption of self-care and enhance resilience.

项目摘要 神经科学方法、技术和分析的快速发展， 精神疾病的病理生理学和治疗取得了重大进展， 将前沿研究转化为针对精神疾病的个性化治疗。在 为了最好地利用这些进步，下一代精神病学研究人员必须 接受集中培训，将转化研究与临床培训相结合。精神病学培训 提供这一重点的计划，与专门的研究时间，领导和相关技能相结合 发展是非常需要的。虽然在医生严重短缺的领域存在担忧， 科学家正在接受培训，也有理由乐观，因为医学博士/博士学位的数量 申请精神科住院医师的毕业生有所增加。我们的临床和转化研究培训 计划，转化研究活动在神经精神病学（火车）的目的是提供特殊的 培训和指导精神病学居民，明确目标是产生临床和翻译 精神病学的研究人员，他们将继续成为独立的医学科学家。该计划的重点是 基础遗传学和神经生物学的破坏之间的关系，以及它们如何与适应性 行为，如在NIMH研究领域标准（RDoC）框架，以及出现 生物标志物可以为临床护理提供信息。培训计划利用我们的专业知识和流程， 教师雇用弥合该领域现有的差距。这包括重点工作和关键内容的专业知识 地区、人群和环境，以及跨转化科学所有范围的方法的使用 从法官到社区我们的结构化计划提供了一个特殊的指导计划， 为参与的居民提供体验机会，并及时进行教学。火车计划是 专门用于培养下一代研究人员，使他们能够翻译神经科学， 遗传学研究促进了我们对广泛的心理健康问题的理解， 治疗。TRAIN促进了转化研究所需的团队科学指导和培训， 通过指导研究项目的进行，强调生产力，以及交付成果 例如建立网络和制定供资建议，使受训人员为下一步的培训做好准备， 学术研究TRAIN还专注于健康和防止倦怠，以鼓励早期 采取自我照顾和增强复原力。