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Translational Research Activities in Neuropsychiatry (TRAIN) - Renewal - 1

神经精神病学转化研究活动 (TRAIN) - 更新 - 1

基本信息

批准号：
10171037
负责人：
MADHUKAR H. TRIVEDI
金额：
$ 21.59万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-10 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10171037
关键词：
Adaptive Behaviors Adoption Area Biological Biological Markers Clinical Clinical Research Cognition Communities Coupled Cultural Diversity Detection Development Diagnosis Disease Doctor of Philosophy Electroencephalography Epigenetic Process Etiology Faculty Foundations Functional disorder Funding Genetic Genetic Research Goals Individual Infrastructure Knowledge Lead Leadership Mental Health Mental disorders Mentors National Institute of Mental Health Neurobiology Neurosciences Neurosciences Research Outcome Physicians Population Precision therapeutics Prevention Process Productivity Proteomics Psychiatric therapeutic procedure Psychiatry Research Research Activity Research Domain Criteria Research Personnel Research Project Grants Research Training Residencies Resources Rural Science Scientist Self Care Solid Structure Target Populations Techniques Technology Time Training Training Programs Translating Translational Research Translations Work Youth addiction base biomarker evaluation burnout career clinical care design improved innovation leadership development medical schools neuroimaging neuropsychiatry next generation novel optimism personalized medicine precision medicine prevent programs prospective resilience skill acquisition skills tool translational scientist treatment optimization treatment response

项目摘要

PROJECT SUMMARY Rapid developments in neuroscientific approaches, technologies, and analytics to understand the pathophysiology and treatment of mental illnesses have resulted in major advances that serve as a strong base toward the translation of cutting-edge research into personalized treatments for psychiatric conditions. In order to best leverage these advances, it is imperative that the next generation of researchers in psychiatry receive focused training that integrates translational research with clinical training. Psychiatric training programs that provide this focus, in conjunction with dedicated research time, and leadership and related skill development, are greatly needed. While there is concern in the field of a profound shortage of physician- scientists being trained, there is also reason for optimism, in that the number of MD/PhD medical school graduates applying for psychiatric residencies has increased. Our clinical and translational research training program, Translational Research Activities In Neuropsychiatry (TRAIN) is designed to provide exceptional training and mentoring to psychiatry residents with the express goal of generating clinical and translational researchers in psychiatry who will go on to become independent physician-scientists. This program focuses on the relationship between disruptions in underlying genetics and neurobiology and how they relate to adaptive behavior, as in the NIMH Research Domain Criteria (RDoC) framework, as well as the emergence of biomarkers that can inform clinical care. The TRAIN program harnesses the expertise and processes our faculty employ to bridge existing gaps in the field. This includes focused work and expertise in critical content areas, populations, and settings, as well as the use of approaches that span all ranges of translational science from the bench to the community. Our structured program provides an exceptional mentoring plan with experiential opportunities to participating residents coupled with timely didactics. The TRAIN program is specifically designed to train the next generation of researchers so that they can translate neuroscience and genetics research into advancements of our understanding of a wide range of mental health problems and treatments. TRAIN facilitates team science mentoring and training that is needed for translational research, with an emphasis on productivity through the conduct of a mentored research project, as well as deliverables such as networking and development of funding proposals to equip trainees for their next steps in training and academic research. TRAIN also focuses on wellness and guarding against burnout to encourage early adoption of self-care and enhance resilience.

项目概要神经科学方法、技术和分析的快速发展，以了解精神疾病的病理生理学和治疗取得了重大进展，成为强有力的致力于将尖端研究转化为精神疾病的个性化治疗。在为了最好地利用这些进步，下一代精神病学研究人员必须接受将转化研究与临床培训相结合的重点培训。精神科培训提供这一重点的计划，结合专门的研究时间、领导力和相关技能发展，非常需要。尽管该领域存在医生严重短缺的担忧—— 接受培训的科学家也有理由乐观，因为医学博士/博士医学院的数量申请精神病学住院医师实习的毕业生有所增加。我们的临床和转化研究培训计划，神经精神病学转化研究活动（TRAIN）旨在提供卓越的对精神病学住院医师进行培训和指导，其明确目标是产生临床和转化精神病学研究人员将继续成为独立的医师科学家。该计划重点关注基础遗传学和神经生物学的破坏之间的关系以及它们与适应性的关系 NIMH 研究领域标准 (RDoC) 框架中的行为，以及可以为临床护理提供信息的生物标志物。 TRAIN 计划利用我们的专业知识和流程聘请教师来弥补该领域现有的差距。这包括关键内容的重点工作和专业知识地区、人口和环境，以及跨越所有转化科学领域的方法的使用从板凳到社区。我们的结构化计划提供了卓越的指导计划为参与的居民提供体验机会以及及时的教学。 TRAIN 程序是专门为培训下一代研究人员而设计，以便他们能够翻译神经科学和遗传学研究促进我们对各种心理健康问题的理解的进步治疗。 TRAIN 促进转化研究所需的团队科学指导和培训，通过指导研究项目以及可交付成果来强调生产力例如建立网络和制定资助建议，使受训者能够进行下一步的培训和学术研究。 TRAIN 还注重健康和防止倦怠，以鼓励尽早采用自我保健并增强复原力。