Long-term Benefits and Risks of Bariatric Surgery in Integrated Care Systems
综合护理系统中减肥手术的长期益处和风险
基本信息
- 批准号:9329410
- 负责人:
- 金额:$ 64.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-15 至 2018-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAdverse eventAgeBariatricsBenefits and RisksBody WeightBody Weight decreasedCaringCessation of lifeCharacteristicsChronic Kidney FailureClinicalClinical Practice GuidelineCodeComorbidityComplicationComputerized Medical RecordDataData CollectionDatabasesDecision MakingDisease remissionEpidemicEthnic OriginEventFutureGenderGoalsGrowthHealthHealth Maintenance OrganizationsHealth PlanningHealthcareHealthcare SystemsHypertensionICD-9IncidenceIntegrated Health Care SystemsInvestmentsKidney DiseasesKnowledgeLong-Term EffectsMalignant NeoplasmsManualsMeasurementMedicalMental HealthMethodsMorbid ObesityNational Institute of Diabetes and Digestive and Kidney DiseasesNon-Insulin-Dependent Diabetes MellitusObesityOperative Surgical ProceduresOutcomeOutcome MeasurePathway interactionsPatientsPersonsPhysiciansPopulationPostoperative PeriodProceduresPublishingRaceRandomized Controlled TrialsRegistriesRepeat SurgeryReportingResearchResearch InfrastructureRetrospective cohort studyRiskSafetySeveritiesSpecificityStatistical ModelsSystemTechniquesTimeUnited StatesWeightadverse outcomebariatric surgerybasecare systemscohortcomparative effectivenesscomparison groupeffective interventionethnic minority populationexperiencefollow-uphealth care deliveryhypertension controlimprovedmembernoveloutcome predictionpopulation basedprospectivepublic health relevanceracial and ethnicresponsesafety studytrial comparing
项目摘要
DESCRIPTION (provided by applicant): The epidemic growth of severe obesity continues unabated, and 36 million U.S. adults (14.5%) currently have a BMI =35 kg/m2. In the last 20 years, bariatric procedures have emerged as the most effective interventions to induce weight loss and improvements in comorbidities. However, evidence about the long-term outcomes of bariatric surgery remains a critical gap. The proposed project will be the largest study to date to
investigate the long-term relationships between bariatric surgery and durable improvements in body weight, hypertension, and renal disease, as well as its association with major operative complications and long-term survival. We will also compare these outcomes to a population-based cohort of severely obese patients who have not had weight loss surgery and investigate demographic and clinical characteristics (e.g., age, gender, race/ethnicity, bariatric procedure type, T2DM severity, and other comorbid medical and mental health conditions and their treatments) that may be associated with beneficial and adverse outcomes of surgery. Building upon methods that have been successfully applied in our prior studies, we will conduct a retrospective cohort study of more than 45,000 severely obese patients who underwent bariatric surgery in three large integrated health care systems over a 17-year period (1997-2013). This is the largest and most diverse bariatric population in the world with 41% racial/ethnic minority patients. Bariatric procedures and long-term outcomes will be identified from existing electronic medical record and registry databases using approaches that have been previously published or validated by members of our team. We will use advanced propensity- based statistical approaches to carefully identify a non-surgical comparison group with severe obesity. And we will investigate the potential for biases in our databases using a combination of primary data collection and chart review. These novel data will allow us to establish the validity of our outcome measures and establish whether subjects who have missing data in our databases have different long-term outcomes than those with complete data. The information gained from this study will enable physicians and patients to more accurately assess the long- term risks and benefits of bariatric surgical intervention and will help guide improvements in pre- and post- operative care pathways for bariatric patients. Our findings will also help improve the return on investment that healthcare systems are making in weight loss surgery.
描述(由申请人提供):严重肥胖的流行性增长持续不减,目前有3600万美国成年人(14.5%)的BMI =35 kg/m2。在过去的20年里,减肥手术已经成为最有效的干预措施,以诱导体重减轻和改善合并症。然而,减肥手术的长期结果的证据仍然是一个关键的差距。拟议的项目将是迄今为止规模最大的研究,
研究减肥手术与体重、高血压和肾脏疾病的持久改善之间的长期关系,以及与主要手术并发症和长期生存率的关系。我们还将这些结果与未进行减肥手术的严重肥胖患者的基于人群的队列进行比较,并调查人口统计学和临床特征(例如,年龄、性别、人种/种族、减肥手术类型、T2 DM严重程度和其他共病医学和心理健康状况及其治疗)。在我们先前研究中成功应用的方法的基础上,我们将对17年(1997-2013)期间在三个大型综合医疗保健系统接受减肥手术的45,000多名严重肥胖患者进行回顾性队列研究。这是世界上最大和最多样化的肥胖人群,其中41%为少数民族患者。减肥手术和长期结果将从现有的电子病历和注册数据库中确定,使用的方法之前已发表或由我们的团队成员验证。我们将使用先进的基于倾向的统计方法来仔细识别患有严重肥胖症的非手术对照组。我们将通过结合原始数据收集和图表审查来调查我们数据库中偏倚的可能性。这些新数据将使我们能够确定我们的结局指标的有效性,并确定我们的数据库中缺失数据的受试者是否具有与完整数据的受试者不同的长期结局。从这项研究中获得的信息将使医生和患者能够更准确地评估减肥手术干预的长期风险和益处,并将有助于指导减肥患者术前和术后护理途径的改进。我们的研究结果还将有助于提高医疗保健系统在减肥手术中的投资回报。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
David Eric Arterburn其他文献
David Eric Arterburn的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('David Eric Arterburn', 18)}}的其他基金
Long-term Costs and Return on Investment for Bariatric Surgery
减肥手术的长期成本和投资回报
- 批准号:
10026626 - 财政年份:2020
- 资助金额:
$ 64.41万 - 项目类别:
Long-term Costs and Return on Investment for Bariatric Surgery
减肥手术的长期成本和投资回报
- 批准号:
10218157 - 财政年份:2020
- 资助金额:
$ 64.41万 - 项目类别:
Long-term Costs and Return on Investment for Bariatric Surgery
减肥手术的长期成本和投资回报
- 批准号:
10375567 - 财政年份:2020
- 资助金额:
$ 64.41万 - 项目类别:
Long-term Costs and Return on Investment for Bariatric Surgery
减肥手术的长期成本和投资回报
- 批准号:
10597046 - 财政年份:2020
- 资助金额:
$ 64.41万 - 项目类别:
Moving to Health: How changing built environments impact weight and glycemic control
走向健康:改变建筑环境如何影响体重和血糖控制
- 批准号:
9980377 - 财政年份:2017
- 资助金额:
$ 64.41万 - 项目类别:
Moving to Health: How changing built environments impact weight and glycemic control
走向健康:改变建筑环境如何影响体重和血糖控制
- 批准号:
9754816 - 财政年份:2017
- 资助金额:
$ 64.41万 - 项目类别:
Moving to Health: How changing built environments impact weight and glycemic control
走向健康:改变建筑环境如何影响体重和血糖控制
- 批准号:
10200029 - 财政年份:2017
- 资助金额:
$ 64.41万 - 项目类别:
Long-term Benefits and Risks of Bariatric Surgery in Integrated Care Systems
综合护理系统中减肥手术的长期益处和风险
- 批准号:
9136837 - 财政年份:2015
- 资助金额:
$ 64.41万 - 项目类别:
Long-term Benefits and Risks of Bariatric Surgery in Integrated Care Systems
综合护理系统中减肥手术的长期益处和风险
- 批准号:
8940898 - 财政年份:2015
- 资助金额:
$ 64.41万 - 项目类别:
Impact of Bariatric Surgery on Long-term Diabetes Remission and Complications
减肥手术对长期糖尿病缓解和并发症的影响
- 批准号:
8672631 - 财政年份:2012
- 资助金额:
$ 64.41万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 64.41万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 64.41万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 64.41万 - 项目类别:
Standard Grant
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 64.41万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 64.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 64.41万 - 项目类别:
Discovery Early Career Researcher Award
RUI: Evaluation of Neurotrophic-Like properties of Spaetzle-Toll Signaling in the Developing and Adult Cricket CNS
RUI:评估发育中和成年蟋蟀中枢神经系统中 Spaetzle-Toll 信号传导的神经营养样特性
- 批准号:
2230829 - 财政年份:2023
- 资助金额:
$ 64.41万 - 项目类别:
Standard Grant
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 64.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 64.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 64.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)