Moving to Health: How changing built environments impact weight and glycemic control
走向健康:改变建筑环境如何影响体重和血糖控制
基本信息
- 批准号:9754816
- 负责人:
- 金额:$ 49.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-15 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAffectAgeAreaArthritisAsthmaBig DataBody WeightBody Weight ChangesBody mass indexCensusesCharacteristicsChildClinicalClinical DataCodeComorbidityComputerized Medical RecordCountyCross-Sectional StudiesDataData LinkagesData SetDyslipidemiasEconomicsEthnic OriginEventGenderGeographyGlycosylated hemoglobin AGrainHealthHealth FoodHealth InsuranceHealth PlanningHealth PolicyHealth systemHealthcare SystemsHome environmentHouseholdHypertensionIncidenceIncomeIndividualInsuranceInterventionLengthLinkLocationLongitudinal cohort studyMeasuresMethodologyMethodsModelingNatural experimentNeighborhoodsNon-Insulin-Dependent Diabetes MellitusObesityOutcomePersonal SatisfactionPrevalencePropertyRaceRandomizedSMART healthSmokingSocioeconomic StatusSourceStatistical MethodsSupermarketSystemTaxesTechnologyTestingTimeWeightWeight maintenance regimenbasebuilt environmentcohortdiabetes riskexperimental studyfarmers marketsfast foodfollow-upglycemic controlhealth care deliveryinsightmembernovelprospectiveresidencesecondary analysissocialurban planningwalkability
项目摘要
SUMMARY
There are multiple links between residential location, built environment (BE), and neighborhood prevalence of
obesity and type 2 diabetes (T2D). Advances in GIS technologies have allowed a shift in geographic scale
from large counties and ZIP codes to more granular census tracts/blocks and individual tax parcels. Fine-
grained data permits more detailed characterization of BE with variables like bus ridership, sidewalk length,
and greenery coverage. Cross-sectional analysis of BE data does not allow causal inferences. Only
longitudinal cohort studies can address the critical question: does residential BE have a causal effect on body
weight changes and glycemic control in the long term? Identifying BE variables most strongly related to health
outcomes would help inform health policies, encourage health-supportive urban planning, and support
consumer residential location decisions. We propose a paradigm shift, modeled after the randomized social
experiment, the Moving to Opportunity Study. We will use data from Group Health (GH), a large integrated WA
State health care system, serving broad economic strata. By attaching a geographic context to anonymized
electronic medical records (EMR) of 320,000 adults (30,000 with T2D) and 90,000 children residing in King
County, WA, we will examine longitudinal relationships between individual-level BE and changes in weight and
glycemic control. More than 100,000 adults and 40,000 children in the cohort moved at least once between
2005 and 2016, allowing a unique opportunity to examine the impact of major changes in BE on long-term
weight and T2D status. Aim 1 will determine whether baseline BE variables can predict longitudinal changes in
body weight and HbA1c over up to 12 years follow-up, independent of baseline measures of socioeconomic
status (SES), demographic variables, and comorbid conditions. Aim 2 will determine whether immediate,
moving-induced changes in BE can predict body weight and HbA1c changes, independent of changes in SES
and other covariates. Aim 3 will determine whether more gradual, secular changes in BE can predict weight
and HbA1c changes, in people who do not move residence, independent of changes in SES and other
covariates. We will develop new spatial analysis methods to address the complexity of intertwining longitudinal
and time-to-event outcomes and spatially-dependent time-varying predictors. The project will afford novel “big
data” linkages between 40+ residential BE characteristics and detailed, longitudinal clinical data, allowing us to
examine body weight trajectories, glycemic control, and incidence of obesity and T2D over 12-years' follow-up.
This natural experiment examining sudden (for movers) and gradual (for non-movers) changes in the BE for a
very large cohort will provide unprecedented insights into the impact of place on health. Our findings will help
urban planners and policymakers target different BE features for intervention, based on local and regional
realities. Consumers and developers can use this information to make informed decisions about neighborhood
features likely to be most supportive of health.
总结
住宅位置,建筑环境(BE)和邻里流行之间存在多重联系。
肥胖和2型糖尿病(T2D)。地理信息系统技术的进步使地理尺度发生了变化
从大的县和邮政编码到更细的人口普查区/街区和个人税收包裹。好吧-
粒度数据允许更详细地描述BE的变量,如公交车乘客量,人行道长度,
和绿化覆盖率。BE数据的横截面分析不允许进行因果推断。只
纵向队列研究可以解决关键问题:住宅BE对身体有因果影响吗?
长期的体重变化和血糖控制?确定与健康关系最密切的BE变量
结果将有助于为卫生政策提供信息,鼓励支持健康的城市规划,并支持
消费者的住宅选址决定。我们提出了一个范式转变,仿照随机社会
实验,移动到机会研究。我们将使用来自Group Health(GH)的数据,
国家卫生保健系统,服务于广泛的经济阶层。通过将地理背景附加到匿名
居住在King的320,000名成年人(30,000名T2D患者)和90,000名儿童的电子医疗记录(EMR)
县,华盛顿州,我们将研究纵向关系之间的个人水平的BE和变化的重量和
血糖控制该队列中有超过100,000名成年人和40,000名儿童至少在
2005年和2016年,这是一个独特的机会,可以检查商业的重大变化对长期的影响,
体重和T2D状态。目标1将确定基线BE变量是否可以预测
长达12年随访期间的体重和HbA1c,与社会经济学基线指标无关
社会经济地位(SES),人口统计学变量和共病条件。目标2将决定是否立即,
运动引起的BE变化可以预测体重和HbA1c的变化,与SES的变化无关
和其他协变量。目标3将确定BE的更渐进的长期变化是否可以预测体重
和HbA1c的变化,在不移动居住的人,独立于SES和其他
协变量我们将开发新的空间分析方法,以解决复杂的交织纵向
和时间-事件结果和空间依赖的时变预测因子。该项目将提供新颖的"大
40多个居民BE特征和详细的纵向临床数据之间的"数据"联系,使我们能够
在12年的随访中检查体重轨迹、血糖控制以及肥胖和T2D的发病率。
这个自然的实验检查了一个人的BE的突然变化(对于移动者)和逐渐变化(对于非移动者)。
非常大的队列将提供前所未有的见解,了解地方对健康的影响。我们的研究结果将有助于
城市规划者和政策制定者针对不同的基础设施特征进行干预,
实消费者和开发商可以利用这些信息对社区做出明智的决定
最可能支持健康的特征。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
David Eric Arterburn其他文献
David Eric Arterburn的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('David Eric Arterburn', 18)}}的其他基金
Long-term Costs and Return on Investment for Bariatric Surgery
减肥手术的长期成本和投资回报
- 批准号:
10026626 - 财政年份:2020
- 资助金额:
$ 49.77万 - 项目类别:
Long-term Costs and Return on Investment for Bariatric Surgery
减肥手术的长期成本和投资回报
- 批准号:
10218157 - 财政年份:2020
- 资助金额:
$ 49.77万 - 项目类别:
Long-term Costs and Return on Investment for Bariatric Surgery
减肥手术的长期成本和投资回报
- 批准号:
10375567 - 财政年份:2020
- 资助金额:
$ 49.77万 - 项目类别:
Long-term Costs and Return on Investment for Bariatric Surgery
减肥手术的长期成本和投资回报
- 批准号:
10597046 - 财政年份:2020
- 资助金额:
$ 49.77万 - 项目类别:
Moving to Health: How changing built environments impact weight and glycemic control
走向健康:改变建筑环境如何影响体重和血糖控制
- 批准号:
9980377 - 财政年份:2017
- 资助金额:
$ 49.77万 - 项目类别:
Moving to Health: How changing built environments impact weight and glycemic control
走向健康:改变建筑环境如何影响体重和血糖控制
- 批准号:
10200029 - 财政年份:2017
- 资助金额:
$ 49.77万 - 项目类别:
Long-term Benefits and Risks of Bariatric Surgery in Integrated Care Systems
综合护理系统中减肥手术的长期益处和风险
- 批准号:
9329410 - 财政年份:2015
- 资助金额:
$ 49.77万 - 项目类别:
Long-term Benefits and Risks of Bariatric Surgery in Integrated Care Systems
综合护理系统中减肥手术的长期益处和风险
- 批准号:
9136837 - 财政年份:2015
- 资助金额:
$ 49.77万 - 项目类别:
Long-term Benefits and Risks of Bariatric Surgery in Integrated Care Systems
综合护理系统中减肥手术的长期益处和风险
- 批准号:
8940898 - 财政年份:2015
- 资助金额:
$ 49.77万 - 项目类别:
Impact of Bariatric Surgery on Long-term Diabetes Remission and Complications
减肥手术对长期糖尿病缓解和并发症的影响
- 批准号:
8672631 - 财政年份:2012
- 资助金额:
$ 49.77万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 49.77万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 49.77万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 49.77万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 49.77万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 49.77万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 49.77万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 49.77万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 49.77万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 49.77万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 49.77万 - 项目类别:
Grant-in-Aid for Scientific Research (C)