Cognitive-Affective Substrates of Smoking: Targets for Maternal Behavior Change

吸烟的认知情感基础：母亲行为改变的目标

• 批准号: 9416374
• 负责人: Suena Huang Massey
• 金额: $ 7万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9416374
• 关键词: Adult; Affective; Age; Aggressive behavior; Alcohol or Other Drugs use; Altruism; Behavior; Biological; Biological Assay; Birth; Characteristics; Child; Child Rearing; Clinical; Cognitive; Communities; Complement; Complex; Data; Data Analyses; Data Collection; Developed Countries; Developing Countries; Discipline of obstetrics; Doctor of Philosophy; Emotions; Empathy; Exhibits; Exposure to; Face; Fetus; First Pregnancy Trimester; Foundations; Future; Goals; Habits; Health; Health Benefit; Health behavior; Hostility; Impulsivity; Interruption; Intervention; Intervention Studies; Jordan; Justice; K-Series Research Career Programs; Lead; Learning; Life; Link; Maternal Behavior; Measurement; Measures; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modeling; Mothers; Motivation; Nicotine; Nicotine Dependence; Nursery Schools; Outcome; Patient Self-Report; Pattern; Personality; Persons; Phenotype; Pilot Projects; Predictive Factor; Pregnancy; Pregnant Women; Preparation; Probability; Prospective Studies; Proxy; Psychiatrist; Recording of previous events; Reporting; Research; Risk; Risk Factors; Sampling; Smoker; Smoking; Techniques; Testing; Third Pregnancy Trimester; Training; United States; Variant; Woman; Work; addiction; antisocial behavior; base; behavior change; brief intervention; cognitive neuroscience; cohort; experience; fetal; improved; intergenerational; maternal cigarette smoking; movie; multilevel analysis; nicotine use in pregnancy; novel; pregnant; prenatal; prenatal exposure; prenatal smoking; programs; prospective; psychiatric symptom; psychologic; public health relevance; skills; smoking cessation; social cognition; stressor; substance abuser; therapy development; transmission process

 DESCRIPTION (provided by applicant): Suena Massey, MD is a board-certified Psychiatrist with additional qualifications in Addiction Medicine who proposes the resubmission application for the Mentored Patient-Oriented Research Career Development Award (K23) entitled, Psychological Mechanisms in Prenatal Smoking Behavior Change. Based on her clinical work with pregnant and non-pregnant substance abusers, Dr. Massey aims to build a foundation for an independent program of research on the psychological characterization of women who successfully quit smoking during pregnancy as a basis for identifying modifiable factors linked to cessation that can be targets for future interventions. To accomplish this long term goal, in this K23 study, she will combine analysis of extant data in a large phenotypically characterized community sample with state-of-the-art longitudinal repeated prospective measurement of prenatal smoking patterns with a new pilot study. This strategy maximizes impact of the K-award study while providing necessary didactic training and mentored experience in the day-to-day conduct of independent research with a prenatal cohort. Specifically, she will examine differences in empathy between women who quit smoking during pregnancy and women who do not drawing on a prenatal cohort oversampled for prenatal smoking (R01 DA023653; PI: L. Wakschlag). Guided by these results, she will conduct a pilot study to develop a multi-level battery for assessing empathy in pregnancy and provide preliminary evidence for its utility for use in future large scale studies of prenatal smoking cessation. Complementing these scientific aims, training goals are to: (1) develop sophisticated analytic skills in multi-level modeling, random-effects regression, and creation of latent variables; (2) acquire depth of expertise in multi-level measurement of empathy including direct assessments, and (3) acquire training in intervention development. Dr. Massey's outstanding mentorship team includes Lead Mentor, Katherine Wisner, MD, MS, and Co-Mentor Lauren Wakschlag, PhD, and Advisors Daniel Mroczek, PhD (Statistician, Personality Research), Michael Fleming, MD (Intervention Development), Jordan Grafman, PhD (Cognitive Neuroscience), and William Grobman, MD (Obstetrics). If prenatal smoking cessation is independently related to empathic capacity as hypothesized, interventions aimed at increasing empathy during pregnancy can significantly improve smoking cessation rates and reduce prenatal exposures to nicotine. Enhancing the unique motivation for behavior change during pregnancy holds the potential to interrupt a devastating intergenerational transmission of risk, while yielding immediate health benefits for mothers.

 描述（由应用程序提供）：医学博士Suena Massey是一名经过董事会认证的精神科医生，在成瘾医学领域拥有其他资格，他们提出了重新提出的指导的注重患者的研究职业发展奖（K23），该奖项（K23）题为“产前吸烟行为”的心理学机制。基于她与怀孕和非怀孕药物虐待者的临床工作，Massey博士旨在为妇女的心理表征独立研究奠定基础，这些妇女在怀孕期间成功戒烟的妇女的心理表征是确定与戒烟有关的可修改因素的基础，这些因素可以成为未来干预措施的目标。为了实现这一长期目标，在这项K23研究中，她将在大型表型表征的社区样本中将额外数据的分析与最新的纵向重复重复预期测量产前吸烟模式的前瞻性测量以及一项新的试点研究。该策略在提供必要的培训时最大程度地提高了K-award研究的影响，并考虑了与产前队列的独立研究日常进行的经验。具体而言，她将研究怀孕期间戒烟的女性与不借鉴产前吸烟产前采样的妇女的同理心差异（R01 DA023653； PI：L。Wakschlag）。在这些结果的指导下，她将进行一项试点研究，以开发多层电池，以评估怀孕的同理心，并为其在未来的大规模吸烟戒烟的大规模研究中提供了初步证据。与这些科学目标相辅相成，培训目标是：（1）在多层次建模，随机效应回归和潜在变量的创建方面发展了复杂的分析技能； （2）在包括直接评估（直接评估）的多层次衡量中获得了深入的专业知识，以及（3）在干预开发方面的获取培训。 Massey博士杰出的心态团队包括主要导师，MD，MS Katherine Wisner和Co-Enctor Lauren Wakschlag，PhD和顾问Daniel Mroczek博士（统计学家，人格研究），Michael Fleming，MD（干预开发）（干预发展）如果假设的产前吸烟与同理心能力独立相关，则旨在增加妊娠期间同理心的干预措施可以显着提高吸烟率并减少产前暴露于尼古丁。增强怀孕期间行为改变的独特动机具有中断毁灭性风险的毁灭性传播的可能性，同时为母亲带来直接的健康益处。