2018 Myelin Gordon Research Conference and Gordon Research Seminar

项目摘要 此申请是为2018年戈登研究研讨会(GRS；3月17日，18月18日)和 关于髓鞘的会议(GRC，3月18-23日)将在美国加利福尼亚州文图拉举行。这些会议汇聚在一起 髓鞘发育、生理学、病理学和治疗前沿的研究人员和实习生。这 会议独特地聚焦于中枢和外周髓鞘，并适时地考虑到人们对髓鞘日益增长的兴趣 生物学和人类疾病以及自2016年在欧洲举行的上一次会议以来的重大进展。这些进展 包括：人类胎儿大脑中少突胶质前体细胞的发育起源；遗传学、表观遗传学和 髓鞘生成的转录调节；对神经元信号触发的增强理解 髓鞘形成；研究髓鞘的新技术；人类髓鞘形成变化的定义 青春期及其与精神障碍的相关性；髓鞘随年龄变化的机制 痴呆症和中风；多发性硬化症的治疗进展，以及恢复的再生策略 髓鞘。这些进展和其他进展使该领域超越了分子、细胞和结构研究。 在以前的会议上讨论过，以解决我们对髓鞘功能的理解中的关键研究差距 关键的发展阶段，这些如何表现为人类疾病，以及生物，小 基于分子、基因和细胞的治疗方法将构成“未来的治疗方法”。这个 第14届GRC“穿越时代的髓鞘”科学计划涵盖了髓鞘在老年人中的进化和功能 儿童、青少年和成人，以及在这些阶段影响髓鞘形成和完整性的疾病。这个 会议将汇集来自学术界和工业界的基础和临床研究人员-近四分之一 它们以前从未在髓鞘GRC上发言过。我们包括了同等比例的高级领导人和 受训人员/早期职业科学家，我们已优先考虑多样性和性别平衡 扬声器。所有参与者将贡献一份口头或海报演示文稿，这些演示文稿是 促进参与者之间富有成效的互动。这些活动和其他GRC活动将刺激和 加快髓鞘生物和医学领域的进展。2018年的格式将以“髓磷脂”开始 GRS“是在前几次会议(2012-16年)取得非凡成功的基础上发展起来的。GRS将提供一项特权 为年轻研究人员提供互动、展示他们最新研究和发展合作的场所，如 以及非正式的社交活动。我们预计将有60多名研究生和博士后研究员参加 GRS和GRC。我们要求提供资金，以支持受邀的私人投资机构和受训人员的差旅和注册费用。

Project Summary This application is to request support for the 2018 Gordon Research Seminars (GRS; March 17, 18) and Conference (GRC, March 18-23) on Myelin to be held in Ventura, CA, USA. These meetings bring together researchers and trainees at the cutting edge of myelin development, physiology, pathology and treatment. This meeting uniquely focuses on central and peripheral myelin and is timely given growing interest in myelin biology and human disease and major advances since the last meeting in Europe in 2016. These advances include: developmental origins of oligodendrocyte precursors in the human fetal brain; genetic, epigenetic and transcriptional regulation of myelin production; an enhanced understanding of neuronal signals triggering myelination; new technologies to study myelin; the definition of myelination changes during human adolescence and its relevance in psychiatric disorders; mechanisms of age-dependent deterioration of myelin in dementia and stroke; progress in treating multiple sclerosis, as well as regenerative strategies to restore myelin. These and other advances position the field to go beyond the molecular, cellular and structural studies covered in previous meetings to address key research gaps in our understanding of myelin function at various key developmental stages, how these manifest as human disease, and the development of biologic, small molecule, gene and cell-based therapeutic approaches that will comprise the “therapies of the future.” The scientific program of the 14th GRC “Myelin Through the Ages” covers evolution and functions of myelin in the child, adolescent and adult, as well as diseases affecting myelin formation and integrity at these stages . The meeting will bring together basic and clinical investigators from academia and industry—almost a quarter of which have never spoken at a Myelin GRC before. We included an equal proportion of senior leaders and trainees/early career scientists and we have prioritized diversity and gender balance among the roster of speakers. All participants will contribute an oral or poster presentation, which serve as key elements to promote productive interactions amongst participants. These and other GRC activities will stimulate and accelerate progress in the field of myelin biology and medicine. The 2018 format will begin with the “Myelin GRS” building on the exceptional success of preceding meetings (2012-16). The GRS will provide a privileged venue for young investigators to interact, present their most current research and develop collaborations, as well as informal social activities. We expect more than 60 graduate students and postdoctoral fellows to attend the GRS and the GRC. We request funds to support travel and registration costs for invited PIs and trainees.