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Histone Deacetylation in Oligodendrocyte Differentiation

少突胶质细胞分化中的组蛋白脱乙酰化

基本信息

批准号：
9551145
负责人：
Patrizia Casaccia
金额：
$ 36.61万
依托单位：
ADVANCED SCIENCE RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9551145
关键词：
Address Adenine Adult Affinity Chromatography Aging Area Binding Bioinformatics Biological Biology Brain Cell Line Cell Lineage Cells ChIP-seq Chemical Engineering Chromatin Collaborations Communities Complex Cuprizone DNA DNA Methylation DNA Modification Methylases DNA Sequence DNA analysis DNMT3a Data Demyelinations Development Differentiation Inhibitor Discipline Electron Microscopy Environment Enzymes Epigenetic Process Funding Gene Expression Gene Silencing Genetic Transcription Genomics Goals Grant Histone Deacetylase Histone Deacetylation Histone H3 Immunohistochemistry Impairment Institutes Lamin B1 Legal patent Manuscripts Maps Mediating Mental disorders Methyltransferase Modeling Multiple Sclerosis Mus Mutant Strains Mice Myelin Neonatal Neurobiology Nuclear Nuclear Envelope Nuclear Structure Oligodendroglia Organism Pattern Productivity Publishing Reporter Research Resources Ribosomes Rodent Role Signal Transduction Solid Systems Biology Technology Testing Transgenic Organisms Translating Zebrafish base cell type data resource experimental study extracellular gene repression genetic information genome-wide histone methylation histone methyltransferase human disease in vivo inhibitor/antagonist mutant myelination neurodevelopment neuropathology new technology novel therapeutics oligodendrocyte lineage progenitor programs protein complex repaired transcriptome transcriptome sequencing white matter

项目摘要

DESCRIPTION (provided by applicant): This is the competitive renewal for a grant that has led to several key discoveries in the field of oligodendrocyte cell identity. Based on our previous record of productivity, solid preliminary data and resources and the collaboration with leaders in the field of epigenetics, chromatin and system biology, we propose to continue to elucidate mechanisms of oligodendrocyte differentiation and myelin formation. The proposed experimental plan will impact not only the field of neurobiology, but also address important biological questions with implications for a broad range of disciplines and contribute to the development of novel therapeutic strategies.

描述（由申请人提供）：这是一个赠款的竞争性更新，导致了在少突胶质细胞身份领域的几个关键发现。基于我们之前凭借我们的生产力记录、坚实的初步数据和资源以及与表观遗传学、染色质和系统生物学领域领导者的合作，我们建议继续阐明少突胶质细胞分化和髓鞘形成的机制。拟议的实验计划不仅将影响神经生物学领域，还将解决重要的生物学问题，对广泛的学科产生影响，并有助于开发新的治疗策略。