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Histone Deacetylation in Oligodendrocyte Differentiation

Histone Deacetylation in Oligodendrocyte Differentiation
少突胶质细胞分化中的组蛋白脱乙酰化
批准号：
9551145
负责人：
Patrizia Casaccia
金额：
$36.61万
依托单位：
ADVANCED SCIENCE RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
已结题
起止时间：
2017-09-01 至 2019-03-31
来源：
https://reporter.nih.gov/project-details/9551145
关键词：
AddressAdenineAdultAffinity ChromatographyAgingAreaBindingBioinformaticsBiologicalBiologyBrainCell LineCell LineageCellsChIP-seqChemical EngineeringChromatinCollaborationsCommunitiesComplexCuprizoneDNADNA MethylationDNA Modification MethylasesDNA SequenceDNA analysisDNMT3aDataDemyelinationsDevelopmentDifferentiation InhibitorDisciplineElectron MicroscopyEnvironmentEnzymesEpigenetic ProcessFundingGene ExpressionGene SilencingGenetic TranscriptionGenomicsGoalsGrantHistone DeacetylaseHistone DeacetylationHistone H3ImmunohistochemistryImpairmentInstitutesLamin B1Legal patentManuscriptsMapsMediatingMental disordersMethyltransferaseModelingMultiple SclerosisMusMutant Strains MiceMyelinNeonatalNeurobiologyNuclearNuclear EnvelopeNuclear StructureOligodendrogliaOrganismPatternProductivityPublishingReporterResearchResourcesRibosomesRodentRoleSignal TransductionSolidSystems BiologyTechnologyTestingTransgenic OrganismsTranslatingZebrafishbasecell typedata resourceexperimental studyextracellulargene repressiongenetic informationgenome-widehistone methylationhistone methyltransferasehuman diseasein vivoinhibitor/antagonistmutantmyelinationneurodevelopmentneuropathologynew technologynovel therapeuticsoligodendrocyte lineageprogenitorprogramsprotein complexrepairedtranscriptometranscriptome sequencingwhite matter

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英文摘要
DESCRIPTION (provided by applicant): This is the competitive renewal for a grant that has led to several key discoveries in the field of oligodendrocyte cell identity. Based on our previous record of productivity, solid preliminary data and resources and the collaboration with leaders in the field of epigenetics, chromatin and system biology, we propose to continue to elucidate mechanisms of oligodendrocyte differentiation and myelin formation. The proposed experimental plan will impact not only the field of neurobiology, but also address important biological questions with implications for a broad range of disciplines and contribute to the development of novel therapeutic strategies.
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会议论文
Environmental Biosensors in the Oligodendrocyte Lineage
  • 批准号：
    10613458
  • 项目类别：
  • 资助金额：
    $114.88万
  • 财政年份：
    2019
  • 负责人：
    Patrizia Casaccia
  • 依托单位：
    ADVANCED SCIENCE RESEARCH CENTER
Environmental biosensors in the oligodendrocyte lineage
  • 批准号：
    10397521
  • 项目类别：
  • 资助金额：
    $115.1万
  • 财政年份：
    2019
  • 负责人：
    Patrizia Casaccia
  • 依托单位：
    ADVANCED SCIENCE RESEARCH CENTER
2018 Myelin Gordon Research Conference and Gordon Research Seminar
  • 批准号：
    9471150
  • 项目类别：
  • 资助金额：
    $2.0万
  • 财政年份：
    2017
  • 负责人：
    Patrizia Casaccia
  • 依托单位：
    GORDON RESEARCH CONFERENCES
Molecular Mechanism of Neuronal Damage in Demyelinating Disorders
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