The Influence of Stress on the Intrinsic Cost of Self-Control

压力对自我控制内在成本的影响

基本信息

  • 批准号:
    9404178
  • 负责人:
  • 金额:
    $ 0.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-12-01 至 2017-09-15
  • 项目状态:
    已结题

项目摘要

Project Summary The use of self-control in everyday life is critical to healthy, adaptive functioning but is often compromised by stress. Neurophysiological responses to stress are thought to alter decision-making circuits in the brain, leading to impaired emotional and behavioral control, and suboptimal decisions that can have deleterious consequences to both psychological and physical health. Exposure to stress is widely considered to be a major predictive factor to the development, maintenance and relapse of a range of mental disorders, including anxiety, depression, and those marked by pathological choice, such as such as obesity, gambling, and substance use. However, a mechanistic account of how stress influences the use of self-control during value- based decision-making is lacking. Recent research has proposed that since the exertion of self-control utilizes cognitive resources, it imposes costs on an individual that may lead them to deviate from goal-directed strategies to control behavior, relying instead on strategies that are less computationally costly but may lead to suboptimal outcomes. The current proposal aims to advance our understanding of how stress might influence decisions to use self-control strategies by measuring the costs individuals assign to self-control use. We will characterize the specific effects of stress on decisions to use self-control using behavioral measures, neuroendocrine measures of stress response, neuroeconomics, functional neuroimaging and computational modeling. Specifically, we will examine how individuals construct the cost of self-control after pre-exposure to stress using a validated neuroeconomic approach (Aim 1). Further, we will characterize the neural mechanisms underlying how self-control decisions are made under stress using model-based fMRI (Aim2). We predict that (1) self-control will be perceived as more costly under stress than under non-stress conditions, (2) the interaction between value-encoding brain regions (i.e., striatum, ventromedial prefrontal cortex (PFC)) and regions that support different aspects of cognitive control (i.e, dorsolateral PFC, anterior cingulate cortex) will register self-control costs in dissociable ways, and (3) that stress will selectively alter patterns of brain activity related to computing self-control costs in these regions. The knowledge obtained from this proposal will advance our understanding of the neurocomputational mechanisms that guide self-control decisions and how these mechanisms are altered under stress. These aims will facilitate the training goals of this proposal by offering training in behavioral economic theory, advanced functional imaging, and computational modeling. The proposed research will have direct implications both for stress-related anxiety and mood disorders and those that are marked by pathological choice, such as obesity, gambling alcoholism and drug addiction.
项目概要 在日常生活中运用自我控制对于健康、适应性功能至关重要,但常常受到以下因素的影响: 压力。人们认为对压力的神经生理反应会改变大脑的决策回路, 导致情绪和行为控制受损,以及可能产生有害影响的次优决策 对心理和身体健康都有影响。暴露于压力被广泛认为是一个主要的 一系列精神障碍的发展、维持和复发的预测因素,包括 焦虑、抑郁以及那些以病理选择为标志的疾病,例如肥胖、赌博和 物质的使用。然而,对压力如何影响价值过程中自我控制的使用的机械解释 缺乏有依据的决策。最近的研究表明,由于自我控制的发挥利用了 认知资源,它给个人带来了成本,可能导致他们偏离目标导向 控制行为的策略,而是依赖计算成本较低但可能导致 次优结果。目前的提案旨在加深我们对压力如何影响的理解 通过衡量个人分配给自我控制使用的成本来决定使用自我控制策略。我们将 使用行为测量来描述压力对使用自我控制的决策的具体影响, 应激反应的神经内分泌测量、神经经济学、功能神经影像学和计算 造型。具体来说,我们将研究个人在预先暴露于环境之后如何构建自我控制的成本。 使用经过验证的神经经济学方法施加压力(目标 1)。此外,我们将表征神经网络 使用基于模型的功能磁共振成像(Aim2)研究如何在压力下做出自我控制决策的机制。我们 预测 (1) 自我控制在压力下会比在无压力条件下付出更大的代价,(2) 价值编码大脑区域(即纹状体、腹内侧前额叶皮层 (PFC))和 支持认知控制不同方面的区域(即背外侧 PFC、前扣带皮层)将 以分离的方式记录自我控制成本,并且(3)压力会选择性地改变大脑活动模式 与计算这些地区的自我控制成本有关。从该提案中获得的知识将 增进我们对指导自我控制决策的神经计算机制的理解以及如何 这些机制在压力下会发生改变。这些目标将通过以下方式促进本提案的培训目标的实现: 提供行为经济理论、高级功能成像和计算建模方面的培训。这 拟议的研究将对与压力相关的焦虑和情绪障碍以及那些与压力相关的焦虑和情绪障碍产生直接影响。 以病理选择为标志的疾病,如肥胖、赌博、酗酒和毒瘾。

项目成果

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Candace M Raio其他文献

Candace M Raio的其他文献

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{{ truncateString('Candace M Raio', 18)}}的其他基金

Neural and affective mechanisms underlying prospective self-control costs
潜在自我控制成本的神经和情感机制
  • 批准号:
    10660515
  • 财政年份:
    2023
  • 资助金额:
    $ 0.19万
  • 项目类别:
Elucidating Neural Mechanisms and Sex Differences in Response to Mindfulness Based Stress Reduction in Generalized Anxiety Disorder
阐明广泛性焦虑症正念减压的神经机制和性别差异
  • 批准号:
    10599978
  • 财政年份:
    2021
  • 资助金额:
    $ 0.19万
  • 项目类别:

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