Occupational Exposure to PM2.5 and Cardiovascular Disease(CVD)

PM2.5 职业接触与心血管疾病 (CVD)

• 批准号: 9356332
• 负责人: MARK RICHARD CULLEN
• 金额: $ 55.23万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9356332
• 关键词: Occupational; Exposure; PM2.5; Cardiovascular; Disease

ABSTRACT The proposed project is responsive to PA-13-302. The objective of this proposal is to extend our work on the health effects of occupational exposures to particulate matter. We will extend follow-up of incident IHD in the active cohort for 5 more years (total of 20 years) and follow subjects past termination of employment, linking the cohort to Medicare claims and cause specific mortality. Aim 1: Develop job-exposure matrices (JEMs) for PM and selected chemicals based on job-level exposures rather than distinct exposure groups (DEGs), adjusting for respirator use. Aim 2: Examine the impact of co- exposure to chemicals and physical stressors—noise and heat—as well as job stress, as independent risk factors for IHD incidence, and as potential confounders, intermediates and effect modifiers of the cardiovascular effects of PM2.5 exposure among all active workers in aluminum smelters and fabrication facilities. Aim 3: Explore the contribution of plant level, community and early life social and environmental characteristics to the incidence of cardiovascular disease. Aim 4: Estimate the associations between cumulative exposure to PM2.5 (as well as the coarse particle fraction PM2.5 - PM10) and longitudinal decline in pulmonary function. Aim 5: Examine the relationships between cumulative exposure to PM2.5, chemicals and COPD and CVD mortality, taking account of health status (risk score while actively employed) and new information on health status after age 65 (after leaving work) derived from linked Medicare claims files. Viewed altogether, continuation of the Alcoa study with the assembled team of investigators provides an unparalleled opportunity to address a host of critical empiric and methodologic issues previously unapproachable. In addition to understanding better what aspects of PM exposure contribute to acute and chronic risk of IHD, COPD and accelerated pulmonary function decline, we can learn how PM interacts with the most ubiquitous of workplace co-exposures as well as the contributions of personal, plant level and social determinants by applying state-of-the-art methods in measurement science and epidemiology.

抽象的 拟议项目响应 PA-13-302。该提案的目的是扩展我们的工作 职业接触颗粒物对健康的影响。我们将延长对 IHD 事件的跟踪 继续活跃队列 5 年（总共 20 年），并跟踪受试者在雇佣关系终止后的情况，链接 医疗保险索赔队列并导致特定死亡率。 目标 1：根据工作水平暴露制定 PM 和选定化学品的工作暴露矩阵 (JEM) 而不是不同的暴露组（DEG），根据呼吸器的使用进行调整。目标 2：检查合作的影响 暴露于化学物质和物理压力源（噪音和热量）以及工作压力，作为独立风险 IHD 发病率的因素，以及潜在的混杂因素、中间因素和效应调节剂 PM2.5 暴露对铝冶炼和制造行业所有在职工人的心血管影响 设施。目标 3：探索植物水平、群落和早期生命社会和环境的贡献 心血管疾病的发病特点。目标 4：估计之间的关联 PM2.5（以及粗颗粒部分 PM2.5 - PM10）的累积暴露和纵向下降 在肺功能方面。目标 5：检查 PM2.5 累积暴露与化学品之间的关系 以及慢性阻塞性肺病 (COPD) 和心血管疾病 (CVD) 死亡率，同时考虑健康状况（积极就业时的风险评分）和新的 来自链接的 Medicare 索赔文件的 65 岁之后（离开工作后）的健康状况信息。 总而言之，美国铝业公司与调查人员组成的团队继续进行的研究提供了一个 前所未有的机会来解决以前的一系列关键经验和方法问题 难以接近的。除了更好地了解 PM 暴露的哪些方面会导致急性和 IHD、COPD 和肺功能加速下降的慢性风险，我们可以了解 PM 如何与 最普遍的工作场所共同暴露以及个人、工厂层面和社会的贡献 通过应用测量科学和流行病学中最先进的方法来确定决定因素。