Administration Core

行政核心

• 批准号: 10380524
• 负责人: MARK RICHARD CULLEN
• 金额: $ 108.94万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-11 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380524
• 关键词: Address; Affect; Area; Autoimmune; Biological; Biological Factors; Biology; Cardiovascular system; Caring; Centers for Population Health; Collaborations; Communities; Country; Discipline; Disease; Economics; Elements; Ensure; Environment; Environmental Risk Factor; Epidemiology; Ethnic group; Foundations; Fright; Gap Junctions; Genes; Genetic; Genetic Markers; Genetic Translation; Genetic Variation; Health; Health Sciences; Health Services Accessibility; Health Services Research; High Performance Computing; Income; Inflammatory; Investigation; Investments; Knowledge; Laboratories; Lead; Leadership; Malignant Neoplasms; Measures; Metabolic syndrome; Outcome; Pathway interactions; Perception; Pilot Projects; Population; Population Heterogeneity; Precision Health; Preventive treatment; Racial Equity; Research; Research Personnel; Research Project Grants; Risk Marker; Role; Science; Sister; Societies; Subgroup; Talents; Technology; Time; Work; biomedical data science; disorder risk; economic disparity; ethnic health disparity; ethnic minority population; experience; gene complementation; genome wide association study; health difference; health disparity; member; novel; racial and ethnic; racial and ethnic disparities; racial minority; racial population; research to practice; social; social disparities; socioeconomics

While genes per se are not an adequate singular foundation for understanding racial and ethnic health disparities, the potential of differential environments—including treatments—interacting with a differential complement of genes in different subgroups does constitute a fertile context for the study of health disparities. At Stanford, we have in place outstanding strengths in the three critical academic elements requisite to form a coordinated, sustainable, and far-reaching research to practice collaboration to address racial and ethnic health disparities with this focus: 1) Extensive experience both with laboratory assessment of genetic markers and their relationships to both disease risk and treatment relevance, 2) Social disparities researchers, spanning epidemiology, evolutionary biology, health services research and economics, and 3) Novel and outstanding analytic and high-performance computing capabilities, recently consolidated in our Department of Biomedical Data Science. Under the auspices of our new Stanford Center for Population Health Sciences, we have recently redoubled our investments in Community Impact. It is in this context that we propose the following overarching aims for this U54 application: Specific Aim 1: Draw together the three principal scientific domains into new working relationships to achieve the aims of each of the three proposed research projects while evolving into an integrated and sustainable science “team” able to take on novel pilot projects proposed by our consortium partners, and sister Centers around the country, while expanding our own portfolio of precision health research focusing on health disparities over time. Specific Aim 2: Availing the Consortium and Implementation Cores, develop and expand relationships with our initial research partners to facilitate critical bidirectional research relationships in the community, starting with the three proposed projects and maturing into a broad, sustainable nexus of partnerships to ensure inclusion of further adversely impacted populations as research goes forward. Specific Aim 3: Develop broad experience with “translation” of genetic and biologic information within different racial and ethnic populations to optimize the application of such precision health approaches to reduce ethnic and racial disparities where such approaches are most relevant.

虽然基因本身并不是理解种族和民族健康的一个充分的单一基础， 差异，差异环境的潜力-包括治疗-与差异相互作用 不同亚群的基因互补确实为研究健康差异提供了丰富的背景。 在斯坦福大学，我们在三个关键的学术要素，形成一个突出的优势， 协调，可持续和深远的研究，以实践合作，以解决种族和民族 健康差距与此重点：1）广泛的经验，既与实验室评估的遗传标记 以及它们与疾病风险和治疗相关性的关系，2）社会差异研究人员， 跨越流行病学，进化生物学，卫生服务研究和经济学，以及3）新颖和 出色的分析和高性能计算能力，最近在我们的 生物医学数据科学在我们新的斯坦福大学人口健康科学中心的赞助下，我们 最近我们在社区影响方面的投资增加了一倍。正是在这一背景下，我们提出了 以下是U 54应用程序的总体目标： 具体目标1：将三个主要科学领域结合起来，形成新的工作关系， 三个拟议研究项目的目标，同时演变成一个综合和可持续的 科学“团队”能够承担我们的联盟合作伙伴和姐妹中心提出的新颖试点项目 在全国范围内，同时扩大我们自己的精准健康研究组合，专注于健康 时间上的差异。 具体目标2：支持联盟和实施核心，发展和扩大与 我们最初的研究合作伙伴，以促进关键的双向研究关系在社会上，开始 与三个拟议项目，并成熟为一个广泛的，可持续的伙伴关系网络，以确保 随着研究的推进，纳入更多受到不利影响的人口。 具体目标3：在不同的国家和地区“翻译”遗传和生物信息方面积累广泛的经验。 种族和民族群体，以优化此类精确健康方法的应用，以减少种族歧视 和种族差异，这些方法最相关。