Occupational Exposure to PM2.5 and Cardiovascular Disease(CVD)
PM2.5 职业接触与心血管疾病 (CVD)
基本信息
- 批准号:9176958
- 负责人:
- 金额:$ 58.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-01 至 2020-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
ABSTRACT
The proposed project is responsive to PA-13-302. The objective of this proposal is to extend our work on the
health effects of occupational exposures to particulate matter. We will extend follow-up of incident IHD in the
active cohort for 5 more years (total of 20 years) and follow subjects past termination of employment, linking
the cohort to Medicare claims and cause specific mortality.
Aim 1: Develop job-exposure matrices (JEMs) for PM and selected chemicals based on job-level exposures
rather than distinct exposure groups (DEGs), adjusting for respirator use. Aim 2: Examine the impact of co-
exposure to chemicals and physical stressors—noise and heat—as well as job stress, as independent risk
factors for IHD incidence, and as potential confounders, intermediates and effect modifiers of the
cardiovascular effects of PM2.5 exposure among all active workers in aluminum smelters and fabrication
facilities. Aim 3: Explore the contribution of plant level, community and early life social and environmental
characteristics to the incidence of cardiovascular disease. Aim 4: Estimate the associations between
cumulative exposure to PM2.5 (as well as the coarse particle fraction PM2.5 - PM10) and longitudinal decline
in pulmonary function. Aim 5: Examine the relationships between cumulative exposure to PM2.5, chemicals
and COPD and CVD mortality, taking account of health status (risk score while actively employed) and new
information on health status after age 65 (after leaving work) derived from linked Medicare claims files.
Viewed altogether, continuation of the Alcoa study with the assembled team of investigators provides an
unparalleled opportunity to address a host of critical empiric and methodologic issues previously
unapproachable. In addition to understanding better what aspects of PM exposure contribute to acute and
chronic risk of IHD, COPD and accelerated pulmonary function decline, we can learn how PM interacts with the
most ubiquitous of workplace co-exposures as well as the contributions of personal, plant level and social
determinants by applying state-of-the-art methods in measurement science and epidemiology.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARK RICHARD CULLEN其他文献
MARK RICHARD CULLEN的其他文献
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{{ truncateString('MARK RICHARD CULLEN', 18)}}的其他基金
Occupational Exposure to PM2.5 and Cardiovascular Disease(CVD)
PM2.5 职业接触与心血管疾病 (CVD)
- 批准号:
9356332 - 财政年份:2016
- 资助金额:
$ 58.39万 - 项目类别:
Spectrum Stanford Center for clinical and Translational Research and Education
Spectrum 斯坦福临床和转化研究与教育中心
- 批准号:
9066829 - 财政年份:2013
- 资助金额:
$ 58.39万 - 项目类别:
Spectrum Stanford Center for Clinical and Translational Research and Education
Spectrum 斯坦福临床和转化研究与教育中心
- 批准号:
9268090 - 财政年份:2013
- 资助金额:
$ 58.39万 - 项目类别:
CAUSES: Causes of Asian American mortality Understood by Socio-Economic Status
原因:通过社会经济状况了解亚裔美国人死亡的原因
- 批准号:
8449599 - 财政年份:2012
- 资助金额:
$ 58.39万 - 项目类别:
CAUSES: Causes of Asian American mortality Understood by Socio-Economic Status
原因:通过社会经济状况了解亚裔美国人死亡的原因
- 批准号:
8280182 - 财政年份:2012
- 资助金额:
$ 58.39万 - 项目类别:
CAUSES: Causes of Asian American mortality Understood by Socio-Economic Status
原因:通过社会经济状况了解亚裔美国人死亡的原因
- 批准号:
8607475 - 财政年份:2012
- 资助金额:
$ 58.39万 - 项目类别:
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