Development of a large area high resolution micro ECoG electrode array

大面积高分辨率微ECoG电极阵列的开发

• 批准号: 9274056
• 负责人: Oliver Graudejus
• 金额: $ 18.94万
• 依托单位: BMSEED, LLC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2018-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274056
• 关键词: Amputees; Animals; Area; Brain; Caliber; Chronic; Clinical; Computers; Custom; Data; Development; Devices; Dose; Eastern Cooperative Oncology Group; Electrocorticogram; Electrodes; Electrophysiology (science); Encapsulated; Epilepsy; Evaluation; Family Felidae; Felis catus; Film; Goals; Gold; Hospitals; Human; Implant; Laboratory Research; Lead; Location; Measures; Mechanics; Mediating; Metals; Microelectrodes; Microfabrication; Modeling; Monitor; Movement; Neurosciences Research; Neurosurgeon; Operative Surgical Procedures; Outcome; Paralysed; Phase; Platinum; Problem Solving; Process; Property; Research Methodology; Resistance; Resolution; Route; Rupture; Seizures; Signal Transduction; Silicones; Site; Small Business Innovation Research Grant; Stretching; Surface; System; Techniques; Technology; Temperature; Testing; Thick; Time; Titanium; Utah; Work; awake; biomaterial compatibility; brain machine interface; brain research; brain tissue; clinical application; clinically relevant; data acquisition; density; design; electric impedance; implantation; improved; in vivo; microstimulation; nanoparticle; neural stimulation; neuroprosthesis; neurotransmission; pre-clinical; prevent; prototype; public health relevance; relating to nervous system; response; tool

 DESCRIPTION (provided by applicant): This work is directed at the development of a microelectrode array for electrocorticography (ECoG) that allows the recording and stimulation of neural activity on the surface of the brain over a large area at high spatial resolution. Existig technologies either allow the recording of neural activity (i) over a large brain area at low spatil resolution (standard commercial ECoGs), or (ii) over a small brain area at high spatial resolution (so called µECoGs). BMSEED aims to produce large-area-high-resolution µECoG electrode arrays (lahrµECoGs). Conventional ECoG electrode arrays are placed on the surface of the brain, and are used as a less invasive alternative to penetrating microelectrodes, which are inserted into the brain tissue. They are used (i) in neuroscience research to explore the fundamentals of how the brain operates, (ii) in brain-machine-interfaces (BMIs) to record neural activity to drive a neuroprosthesis for amputees or to move a computer cursor for the paralyzed, and (iii) for monitoring neural activity during epilepsy surgery to identify the regions of the corex that generate seizures, which subsequently are removed. These applications would benefit from BMSEED's lahrµECoG because it would provide more accurate localization of the recorded signals (i.e., normal neural activity as well as seizures) over a large area, thus improving brain research, making BMIs more robust, and improving clinical outcomes in epilepsy surgery by providing the neurosurgeon with more accurate localization of seizure activity. In all ECOGs, each recording electrode requires one wire to electrically connect to the data acquisition system without intersecting (i.e., without shorting) with other wires. This becomes increasingly difficult as the density and total number of electrodes increases. BMSEED's lahrµECoG solves this problem by routing the lead wires on multiple levels. In addition, our proprietary technology to produce mechanically robust microelectrodes using microfabrication techniques allows us to reduce the thickness, thus the stiffness, of the device, making the implant more compliant. Importantly, BMSEED's lahrµECoG consists entirely of materials that are suitable for implantation in humans, thus simplifying the FDA approval process. The first specific aim is to optimize the profile of the slope between different levels to provide a reliable electrical connection, and to fabricate and electromechanically characterize prototypes of the lahrµECoG. The second aim is to demonstrate the biocompatibility and capabilities of the prototypes. To that end, a lahrµECoG will be chronically implanted in five cats, and neural recording and micro-stimulation data will be obtained for at least two months. At the end of phase I, BMSEED will have (i) developed the capability to produce multi-level metallization and prototypes of lahrµECoGs, and (ii) characterized their capabilities in a cat model. In phase II, BMSEED will extend the lahrµECoGs development to multi-level metallization on larger, clinically relevant substrate sizes. Our customers will initially be research laboratories, and, after FDA approval, biomedical companies for BMI applications and hospitals for clinical applications.

 描述（由申请人提供）：这项工作旨在开发一种用于皮层电图（ECoG）的微电极阵列，该阵列允许以高空间分辨率记录和刺激大面积大脑表面上的神经活动。心电图技术允许记录（i）在低空间分辨率的大大脑区域（标准商业ECoG）上的神经活动，或（ii）在高空间分辨率的小大脑区域（所谓的µ ECoG）上的神经活动。BMSEED旨在生产大面积高分辨率µECoG电极阵列（lahrµ ECoG）。传统的ECoG电极阵列被放置在大脑的表面上，并且被用作插入脑组织中的穿透微电极的侵入性较小的替代方案。它们被用于（i）神经科学研究，以探索大脑如何运作的基本原理，（ii）在脑机接口（BMI）中记录神经活动，以驱动截肢者的神经假体或移动瘫痪者的计算机光标，以及（iii）在癫痫手术期间监测神经活动，以确定产生癫痫发作的corex区域，随后将其移除。这些应用将受益于BMSEED的lahrµECoG，因为它将提供更准确的记录信号定位（即，正常的神经活动以及癫痫发作），从而改善大脑研究，使BMI更稳健，并通过为神经外科医生提供更准确的癫痫发作活动定位来改善癫痫手术的临床结果。在所有的ECOG中，每个记录电极需要一根电线电连接到数据采集系统而不交叉（即，而不短路）。这变得越来越困难 随着电极的密度和总数的增加。BMSEED的lahrµECoG通过在多个层面上布线引线解决了这个问题。此外，我们使用微加工技术生产机械坚固的微电极的专有技术使我们能够降低器械的厚度，从而降低器械的刚度，使植入物更具顺应性。重要的是，BMSEED的lahrµECoG完全由适合植入人体的材料组成，从而简化了FDA的批准程序。第一个具体目标是优化不同水平之间的斜坡轮廓，以提供可靠的电气连接，并制造和机电表征lahrµECoG的原型。第二个目的是证明原型的生物相容性和能力。为此，将在5只猫中长期植入lahrµECoG，并将获得至少两个月的神经记录和微刺激数据。在第一阶段结束时，BMSEED将（i）开发生产多层金属化和lahrµ ECoG原型的能力，并（ii）在cat模型中表征其能力。在第二阶段，BMSEED将把lahrµECoGs的开发扩展到更大的临床相关基板尺寸上的多层金属化。我们的客户最初将是研究实验室，在FDA批准后，将是BMI应用的生物医学公司和临床应用的医院。