Determinants of age-induced hearing loss and reversal strategies

年龄引起的听力损失的决定因素和逆转策略

基本信息

  • 批准号:
    9340057
  • 负责人:
  • 金额:
    $ 162万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-01 至 2021-05-31
  • 项目状态:
    已结题

项目摘要

Abstract Age-related hearing loss (ARHL) or presbycusis is the most prevalent sensory deficit and with the increase in life expectancy, it is predicted to have vast impact in the well-being of our society. Indeed, audition and communication is the essence of our human interactions. The overall framework for this programmatic proposal is that a comprehensive understanding of ARHL is only possible through studies of not only the vulnerable synaptic and neural structures of the inner ear, but also examination of the neural plasticity that occurs in response to changes at the neurites of spiral ganglion neurons. We have brought together expert individuals from genetics to cell biology and physiology (Tempel, Yamoah, Ricci, and Gratton). These investigators have already worked together in a highly synergistic and productive manner. There are three projects (P) served by three Cores (Administrative, Mouse Genetics and Structural Analysis Cores) to test the Central Hypothesis that the aging auditory sensory epithelia undergo structural changes that allow the high K+ endolymph to leak into the perilymph, triggering HC and SGN depolarization, increased intracellular Ca2+ ([Ca2+]i) and subsequent “silent” synaptic and neuronal degeneration (P2, P3). We predict that structural changes are mediated by weakening tight junctions (TJs) in the aging cochlear sensory epithelium (P1, Core C). Genetic manipulation of Claudin 9 and Occludin, two identified TJ proteins in the sensory epithelium, that show robust reduction in expression levels, will be used as prototypes together with three additional ARHL models to test our hypothesis (P1-3, Cores B-C). We propose that neural and synaptic alterations at the periphery (P2, P3) will mediate cellular changes that confer long-lasting alterations auditory system. The proposed studies will reveal critical neural and synaptic mechanisms of ARHL. New therapeutic targets for the treatment of ARHL will be assessed, tested and proposed, thus, transforming and shifting the prevailing paradigm to mechanistic and translational platforms.
摘要 听觉相关性听力损失(ARHL)或老年性耳聋是最普遍的感觉缺陷, 预期寿命,预计将对我们社会的福祉产生巨大影响。事实上, 沟通是我们人类互动的本质。本方案提案的总体框架 只有通过对弱势群体的研究, 内耳的突触和神经结构,但也检查神经可塑性,发生在 对螺旋神经节神经元突起变化的反应。我们召集了专家 从遗传学到细胞生物学和生理学(Tempel,Yamoah,Ricci和Gratton)。这些调查人员 已经以高度协同和富有成效的方式共同努力。 有三个项目(P)由三个核心(行政,小鼠遗传学和结构分析)服务 核心)来检验中心假设,即衰老的听觉上皮细胞经历结构变化, 允许高K+内淋巴渗漏到外淋巴中,触发HC和SGN去极化,增加 胞内Ca 2+([Ca 2 +]i)和随后的“沉默”突触和神经元变性(P2,P3)。我们预测 结构变化是由老化的耳蜗感觉神经中的紧密连接(TJ)减弱所介导的。 上皮(P1,核心C)。Claudin 9和Occludin的遗传操作,两种鉴定的TJ蛋白, 表现出表达水平强烈降低的感觉上皮将与 三个额外的ARHL模型来测试我们的假设(P1-3,核心B-C)。我们认为神经和突触 外周(P2,P3)的改变将介导细胞变化,从而赋予听觉的长期改变 系统这些研究将揭示ARHL的关键神经和突触机制。新的治疗 将评估、测试和提出治疗ARHL的目标,从而改变和改变 流行的模式,以机械和翻译平台。

项目成果

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EBENEZER N YAMOAH其他文献

EBENEZER N YAMOAH的其他文献

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{{ truncateString('EBENEZER N YAMOAH', 18)}}的其他基金

Administrative Core
行政核心
  • 批准号:
    10496281
  • 财政年份:
    2023
  • 资助金额:
    $ 162万
  • 项目类别:
Determinants of age-induced hearing loss and reversal strategies
年龄引起的听力损失的决定因素和逆转策略
  • 批准号:
    10496280
  • 财政年份:
    2023
  • 资助金额:
    $ 162万
  • 项目类别:
Animal, Behavior and Tissue Core
动物、行为和组织核心
  • 批准号:
    10496282
  • 财政年份:
    2023
  • 资助金额:
    $ 162万
  • 项目类别:
Molecular and Functional Mechanisms of the aging auditory neuron
衰老听觉神经元的分子和功能机制
  • 批准号:
    10496285
  • 财政年份:
    2023
  • 资助金额:
    $ 162万
  • 项目类别:
Regulation of hair cell functions
毛细胞功能的调节
  • 批准号:
    9464520
  • 财政年份:
    2017
  • 资助金额:
    $ 162万
  • 项目类别:
Inner ear ion channels in healthy and diseased conditions
健康和患病条件下的内耳离子通道
  • 批准号:
    10745190
  • 财政年份:
    2017
  • 资助金额:
    $ 162万
  • 项目类别:
Inner ear ion channels in healthy and diseased conditions
健康和患病条件下的内耳离子通道
  • 批准号:
    10194449
  • 财政年份:
    2017
  • 资助金额:
    $ 162万
  • 项目类别:
Regulation of hair cell functions
毛细胞功能的调节
  • 批准号:
    9897410
  • 财政年份:
    2017
  • 资助金额:
    $ 162万
  • 项目类别:
Inner ear ion channels in healthy and diseased conditions
健康和患病条件下的内耳离子通道
  • 批准号:
    9976492
  • 财政年份:
    2017
  • 资助金额:
    $ 162万
  • 项目类别:
Mouse Genetics Core
小鼠遗传学核心
  • 批准号:
    9151169
  • 财政年份:
    2016
  • 资助金额:
    $ 162万
  • 项目类别:

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