Augmenting Cognitive Training in Older Adults - The ACT Grant
增强老年人的认知训练 - ACT 补助金
基本信息
- 批准号:9339496
- 负责人:
- 金额:$ 115.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-01 至 2021-04-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAgeAge-YearsAge-associated memory impairmentAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease riskAreaArizonaArousalAttentionBlood VesselsBrainBrain regionCerebrumCharacteristicsCholineClinicalClinical TrialsCognitiveCognitive agingCoupledDemographic FactorsDiabetes MellitusDiseaseEducational InterventionElderlyElderly manElderly womanEnrollmentExposure toFamily history ofFloridaFreezingFunctional Magnetic Resonance ImagingGenderGenotypeGrantGrowthImpaired cognitionIndividualIndividual DifferencesInferiorInstitutesInterventionLearningMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasuresMedialMetabolicMetabolismMethodsMotorMulti-Institutional Clinical TrialN-acetylaspartateNatureNeurocognitiveNeurodegenerative DisordersNeuronal PlasticityOutcomeOutcome MeasureParietal LobeParticipantPerformancePhasePhysiologicalPlacebosPopulationPredictive ValuePrefrontal CortexPrevalenceProtonsPublic HealthRandomizedRandomized Clinical TrialsReadinessRecording of previous eventsRecruitment ActivityResearchResearch InfrastructureRestRisk FactorsScienceSecondary toSharkShort-Term MemorySiteStructureSystemTestingTimeTrainingTraining and EducationUnited StatesUniversitiesactive controlage relatedassociation cortexbasecognitive abilitycognitive enhancementcognitive functioncognitive performancecognitive taskcognitive trainingcombateffective interventionexperiencefollow-upfrontal lobefunctional improvementfunctional outcomesfunctional statusgamma-Aminobutyric Acidimprovedinsightintervention effectmemory encodingmulti-site trialmultimodalitymyoinositolneuroimagingneuroimaging markerpower analysispreventprocessing speedrelating to nervous systemresponseskillswhite matter
项目摘要
ABSTRACT:
This randomized clinical trial will test whether transcranial direct current stimulation (tDCS) of frontal cortices enhances
neurocognitive and functional outcomes achieved from cognitive training in older adults experiencing age-related
cognitive decline. Change in well-validated measures of neurocognitive function and everyday abilities will serve as
outcome measures. Functional and structural neuroimaging biomarkers of neural plasticity and learning (fMRI, GABA
MRS, etc.) will measure intervention-associated alterations in specific brain regions impacted by cognitive aging. tDCS
is a noninvasive brain stimulation method that facilitates neural plasticity and learning. Accordingly, when used as an
adjunctive intervention, tDCS may augment cognitive training effects. This study will leverage existing multisite clinical
trial infrastructure at McKnight Brain Institutes located in two of the states with the largest representation of older adults
in the United States: University of Florida, University of Miami, and University of Arizona. Adults over the age of 65
represent the fastest growing group in the US population. As such, age-related cognitive decline represents a major
concern for public health. Recent research suggests that cognitive training in older adults can improve cognitive
performance, with effects lasting up to 10 years. However, effects are typically limited to the tasks trained, with little
transfer to other cognitive abilities or everyday skills. Effects may also be reduced in people with Alzheimer's
disease risk factors. A two-phase multisite randomized clinical trial will examine the individual and combined impact
of pairing cognitive training with transcranial direct current stimulation (tDCS) in older adults experiencing age-related
cognitive decline (n = 360; 120 per site). Participants will consist of elderly men and women 65-90 years of age with
evidence of age-related cognitive decline, but not MCI or Alzheimer's disease (MoCA≥25). We will compare changes
in cognitive and brain function resulting from CT and CT combined with tDCS using a comprehensive neurocognitive,
clinical, and multimodal neuroimaging assessment of brain structure, function, and metabolic state. Functional
magnetic resonance imaging (fMRI) will be used to assess brain response during working memory, attention, and
memory encoding; the active cognitive abilities trained by CT. Proton magnetic resonance spectroscopy (MRS) will
assess markers of neural plasticity, GABA concentrations, and cerebral metabolism. We hypothesize that: 1) tDCS
will enhance neurocognitive function, brain function, and functional outcomes from CT; 2) Effects of tDCS on CT will
be maintained up to 12 months following training, and 3) Neuroimaging biomarkers of cerebral metabolism, neural
plasticity (GABA concentrations) and functional brain response (fMRI) during resting vs. active cognitive tasks will
predict individual response to tDCS, with certain Alzheimer's risk factors (e.g., APOE4 genotype, family history of
Alzheimer's disease) predicting poorer cognitive and functional outcome. To date, no studies have
comprehensively examined combined CT and tDCS intervention in the elderly. This study will provide definitive insight
into the value of combating cognitive decline in a rapidly aging US population using tDCS with cognitive training.
摘要:
这项随机临床试验将测试额叶皮质的经颅直流电刺激(Tdcs)是否增强。
与年龄相关的老年人接受认知训练后获得的神经认知和功能结果
认知能力下降。经过充分验证的神经认知功能和日常能力测量的变化将起到
结果衡量标准。神经可塑性和学习的功能和结构神经成像生物标记物(fMRI、GABA
夫人等)将测量受认知老化影响的特定大脑区域与干预相关的变化。Tdcs
是一种促进神经可塑性和学习的非侵入性脑刺激方法。因此,当用作
辅助性干预,可增强认知训练效果。这项研究将利用现有的多点临床
麦克奈特大脑研究所的试验基础设施位于老年人人数最多的两个州
在美国:佛罗里达大学、迈阿密大学和亚利桑那大学。65岁以上的成年人
代表着美国人口中增长最快的群体。因此,与年龄相关的认知能力下降是一个主要的
对公共卫生的关注。最近的研究表明,老年人的认知训练可以改善认知能力
性能,有效期长达10年。然而,效果通常仅限于训练的任务,几乎没有
转移到其他认知能力或日常技能上。阿尔茨海默氏症患者的影响也可能会降低
疾病风险因素。一项两阶段多点随机临床试验将检查个体和联合影响
认知训练与经颅直流电刺激(Tdcs)在与年龄相关的老年人中的配对
认知功能减退(n=360;每个站点120个)。参加者将由65-90岁的老年男性和女性组成
与年龄相关的认知能力下降的证据,但不是轻度认知障碍或阿尔茨海默病(≥25)。我们将比较变化
在认知和脑功能方面,CT和CT结合TDC使用全面的神经认知,
对大脑结构、功能和代谢状态的临床和多模式神经成像评估。功能性
磁共振成像(FMRI)将被用来评估大脑在工作记忆、注意力和
记忆编码;CT训练的主动认知能力。质子磁共振波谱(MRS)将
评估神经可塑性、GABA浓度和大脑代谢的标记物。我们假设:1)tdcs
将增强神经认知功能、脑功能和CT的功能结果;2)tDCs对CT将
在训练后维持12个月,以及3)脑代谢、神经功能的神经成像生物标记物
静息与主动认知任务的可塑性(GABA浓度)和脑功能反应(FMRI)将
使用某些阿尔茨海默氏症危险因素(例如,APOE4基因,家族病史)预测个体对tDCs的反应
阿尔茨海默病)预示较差的认知和功能结果。到目前为止,还没有研究表明
综合研究CT和TDCS联合干预在老年人群中的应用。这项研究将提供明确的见解
在快速老龄化的美国人口中,使用tdcs结合认知训练对抗认知衰退的价值。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
RONALD A COHEN其他文献
RONALD A COHEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('RONALD A COHEN', 18)}}的其他基金
Interventions to improve alcohol-related comorbidities along the gut-brain axis in persons with HIV infection
改善 HIV 感染者沿肠-脑轴的酒精相关合并症的干预措施
- 批准号:
10682449 - 财政年份:2021
- 资助金额:
$ 115.47万 - 项目类别:
Novel food-based approach for prevention of age-associated cognitive decline inolder adults with obesity
预防肥胖老年人与年龄相关的认知能力下降的基于食物的新方法
- 批准号:
10395140 - 财政年份:2021
- 资助金额:
$ 115.47万 - 项目类别:
Interventions to improve alcohol-related comorbidities along the gut-brain axis in persons with HIV infection
改善 HIV 感染者沿肠-脑轴的酒精相关合并症的干预措施
- 批准号:
10304322 - 财政年份:2021
- 资助金额:
$ 115.47万 - 项目类别:
Augmenting Cognitive Training in Older Adults - The ACT Grant
增强老年人的认知训练 - ACT 补助金
- 批准号:
9194772 - 财政年份:2016
- 资助金额:
$ 115.47万 - 项目类别:
Augmenting Cognitive Training in Older Adults - The ACT Grant
增强老年人的认知训练 - ACT 补助金
- 批准号:
9925767 - 财政年份:2016
- 资助金额:
$ 115.47万 - 项目类别:
Obesity and Type-2 Diabetes: Bariatric Surgery Effects on Brain Function
肥胖和 2 型糖尿病:减肥手术对脑功能的影响
- 批准号:
8878247 - 财政年份:2014
- 资助金额:
$ 115.47万 - 项目类别:
Obesity and Type-2 Diabetes: Bariatric Surgery Effects on Brain Function
肥胖和 2 型糖尿病:减肥手术对脑功能的影响
- 批准号:
8697728 - 财政年份:2014
- 资助金额:
$ 115.47万 - 项目类别:
Effects of experimentally-induced reductions in alcohol consumption on brain cognitive, and clinical outcomes and motivation for changing drinking in older persons with HIV infection
实验诱导减少饮酒量对 HIV 感染老年人的大脑认知、临床结果和改变饮酒动机的影响
- 批准号:
10425847 - 财政年份:2011
- 资助金额:
$ 115.47万 - 项目类别:
Effects of experimentally-induced reductions in alcohol consumption on brain cognitive, and clinical outcomes and motivation for changing drinking in older persons with HIV infection
实验诱导减少饮酒量对 HIV 感染老年人的大脑认知、临床结果和改变饮酒动机的影响
- 批准号:
10178230 - 财政年份:2011
- 资助金额:
$ 115.47万 - 项目类别:
Effects of experimentally-induced reductions in alcohol consumption on brain cognitive, and clinical outcomes and motivation for changing drinking in older persons with HIV infection
实验诱导减少饮酒量对 HIV 感染老年人的大脑认知、临床结果和改变饮酒动机的影响
- 批准号:
9335770 - 财政年份:2011
- 资助金额:
$ 115.47万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 115.47万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 115.47万 - 项目类别:
Continuing Grant
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 115.47万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 115.47万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 115.47万 - 项目类别:
Fellowship
Walkability and health-related quality of life in Age-Friendly Cities (AFCs) across Japan and the Asia-Pacific
日本和亚太地区老年友好城市 (AFC) 的步行适宜性和与健康相关的生活质量
- 批准号:
24K13490 - 财政年份:2024
- 资助金额:
$ 115.47万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Discovering the (R)Evolution of EurAsian Steppe Metallurgy: Social and environmental impact of the Bronze Age steppes metal-driven economy
发现欧亚草原冶金的(R)演变:青铜时代草原金属驱动型经济的社会和环境影响
- 批准号:
EP/Z00022X/1 - 财政年份:2024
- 资助金额:
$ 115.47万 - 项目类别:
Research Grant
ICF: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.
ICF:中性粒细胞和细胞衰老:促进与年龄相关疾病的恶性循环。
- 批准号:
MR/Y003365/1 - 财政年份:2024
- 资助金额:
$ 115.47万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 115.47万 - 项目类别:
Standard Grant
Shaping Competition in the Digital Age (SCiDA) - Principles, tools and institutions of digital regulation in the UK, Germany and the EU
塑造数字时代的竞争 (SCiDA) - 英国、德国和欧盟的数字监管原则、工具和机构
- 批准号:
AH/Y007549/1 - 财政年份:2024
- 资助金额:
$ 115.47万 - 项目类别:
Research Grant