2017 Mechanisms of Membrane Transport Gordon Research Conference and Gordon Research Seminar

2017膜传输机制戈登研究会议暨戈登研究研讨会

• 批准号: 9330325
• 负责人: Hassane S Mchaourab
• 金额: $ 2.2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330325
• 关键词: Achievement; Attention deficit hyperactivity disorder; Autistic Disorder; Carrier Proteins; Cell Survival; Cell membrane; Cells; Charge; Chemicals; Cognitive; Collaborations; Communication; Computational Technique; Cryoelectron Microscopy; Development; Diabetic Retinopathy; Digestive System Disorders; Disease; Employee Strikes; Ensure; Environment; Financial Support; Fostering; Functional disorder; Future; Goals; Homeostasis; Intention; Ion Channel; Ions; Kidney; Kidney Diseases; Kinetics; Knowledge; Mediating; Membrane Transport Proteins; Mental Depression; Mentors; Methodology; Mission; Molecular; Movement; Mutation; Neuraxis; Neurologic; Neurotransmitters; Nutrient; Oral; Organism; Pathology; Pathway interactions; Physiological; Postdoctoral Fellow; Recruitment Activity; Reproducibility; Research; Research Personnel; Resolution; Science; Scientist; Seasons; Senior Scientist; Serum; Signal Transduction; Structure; Synapses; Syndrome; System; Technology; Therapeutic; Time; Training; Transmembrane Transport; United States National Institutes of Health; Waste Products; Work; Xenobiotics; career; cohort; disease-causing mutation; gastrointestinal system; graduate student; improved; insight; lectures; meetings; news; peer support; personalized medicine; posters; programs; protein transport; solute; structural biology; success; symposium; therapeutic development

Project Summary The movement of ions, solutes, nutrients, waste products as well as essential molecules across cell membranes is mediated by transport proteins. Ion channels specialize in the conduction of charged ions, such as Na+, K+ and Cl-, thereby establishing and modulating the electric and chemical signals that facilitate communications between cells and is an essential feature of the central nervous system. Transporters have more diverse substrate profiles that include the import of nutrients and the export of waste products and xenobiotics. For example, neurotransmitter transporters control synaptic signaling while solute transporters and ion channels in the kidney and digestive system act in concert to regulate serum ion concentrations. Together channels and transporters are critical players in cellular homeostasis and the physiological functioning of an organism. Dysfunction of transport proteins directly leads to a spectrum of diseases in the central nervous systems and in the gut and kidney. Among these are Barter’s syndrome, diabetic retinopathy, autism, attention deficit hyperactivity disorder, and depression. The mission of the Mechanisms of Membrane Transport GRC is to advance the understanding of ion channels and transporters at the structural, mechanistic and physiological levels so that we may better illuminate the molecular basis of diseases and develop therapeutic strategies. A Gordon Research Seminar will be organized by young investigators and trainees in the two days prior to the GRC and will serve to further two NIH training priorities of discussion of career options and rigor and reproducibility in science. To achieve this goal, we will bring together a diverse cadre of scientists at the forefront of the field to present and compare results, discuss news ideas and establish collaborations in an intense and highly focused environment.

项目概要 离子、溶质、营养物质、废物以及必需分子在细胞内的运动 膜是由转运蛋白介导的。离子通道专门传导带电离子，例如 Na+、K+ 和 Cl-，从而建立和调节电信号和化学信号，从而促进 细胞之间的通讯是中枢神经系统的一个重要特征。运输商有 更多样化的底物概况，包括养分的进口和废物的出口 异生素。例如，神经递质转运蛋白控制突触信号传导，而溶质转运蛋白和 肾脏和消化系统中的离子通道协同作用来调节血清离子浓度。一起 通道和转运蛋白是细胞稳态和生理功能的关键参与者 生物。转运蛋白功能障碍直接导致中枢神经一系列疾病 系统以及肠道和肾脏。其中包括巴特综合症、糖尿病视网膜病变、自闭症、注意力集中症 缺陷多动障碍和抑郁症。膜传输GRC机制的使命是 促进对离子通道和转运蛋白结构、机制和生理学的理解 水平，以便我们更好地阐明疾病的分子基础并制定治疗策略。一个 戈登研究研讨会将在会议前两天由年轻研究者和实习生组织 GRC 并将进一步推动 NIH 的两个培训重点，即职业选择的讨论和严格性以及 科学的可重复性。为了实现这一目标，我们将汇集多元化的科学家骨干队伍 站在该领域的最前沿，展示和比较结果、讨论新闻想法并建立合作 紧张且高度集中的环境。