IGF::OT::IGF Plating of Oncology Interrogation Tools Library

IGF::OT::IGF 肿瘤学询问工具库电镀

• 批准号: 9568981
• 负责人: CHARLES JOHNSON
• 金额: $ 0.98万
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-23 至 2017-03-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9568981
• 关键词: Biology; Chemicals; Collection; Contractor; Contracts; Dimethyl Sulfoxide; Exercise; Fees; Government; Informatics; Investigational Therapies; Libraries; Library Services; Maps; NCI Center for Cancer Research; Names; Pathway interactions; Privatization; Research Infrastructure; Resources; Sampling; Services; Solvents; Specific qualifier value; Therapeutic; base; cancer diagnosis; cancer therapy; cost; drug development; drug discovery; high throughput screening; multidisciplinary; oncology; planetary Atmosphere; programs; repository; screening; seal; small molecule; tool

The Chemical Biology Consortium (CBC) has been established through the NCI Division of Cancer Treatment and Diagnosis (DCTD) in conjunction with the Center for Cancer Research (CCR) and the Office of the Director (OD). The CBC is a multidisciplinary network comprised of academic, government and private entities that interacts collaboratively to support execution of drug discovery and development projects within the NCI Experimental Therapeutics Program (NExT). The CBC centers along with DCTD’s existing resources, establishes a complete drug discovery and development platform for oncology therapeutics. One critical infrastructure resource within the CBC is small molecule screening library services in support of high-throughput screening (HTS) projects. The CBC Screening Libraries Center (CBCSLC) provides this resource capability. The CBCSLC was originally established in 2010 under the name Chemical Biology Consortium Small Molecule Repository (CBCSMR). The CBCSLC will be responsible for the storage, distribution, replenishment and expansion of our current 130,000 compound small molecule screening library and providing associated infrastructure, technical and informatics services. The Contractor shall generate 12 copies of plated sets heat sealed under an inert atmosphere from the Oncology Interrogation Tools Library as specified below. The plates shall be stored under conditions that insures the integrity of the samples until ready for distribution. Storage may be for several years. Compound Number: ~600 Compound Collection: Oncology Interrogation Tools Concentration: 10 mM Volume: 1-10 uL (TBD) Mols: 1-10 nM (TBD) Solvent: DMSO Plate Type: Greiner 781280, 384-well, single-use (or similar) Plate Format: TBD In addition, the Contractor shall: 1) Generate electronic plate maps and any other descriptive information necessary for proper utilization of the samples (e.g. target/pathways annotation) This task order will exercise Task 3 of the base IDIQ contract. In addition, this task order will be non-severable cost-reimbursement-plus-fixed-fee.

化学生物学联盟（CBC）是通过NCI癌症治疗和诊断部门（DCTD）与癌症研究中心（CCR）和主任办公室（OD）联合建立的。 CBC是一个多学科网络，由学术、政府和私人实体组成，它们相互协作，支持NCI实验治疗计划（NExT）内药物发现和开发项目的执行。 CBC沿着DCTD现有资源，为肿瘤治疗学建立一个完整的药物发现和开发平台。 CBC内部的一个关键基础设施资源是支持高通量筛选（HTS）项目的小分子筛选库服务。 CBC筛选库中心（CBCSLC）提供这种资源能力。 CBCSLC最初成立于2010年，名为化学生物学联盟小分子储存库（CBCSMR）。 CBCSLC将负责我们现有的130，000个化合物小分子筛选库的存储，分发，补充和扩展，并提供相关的基础设施，技术和信息服务。 承包商应根据以下规定，从肿瘤询问工具库中生成12份在惰性气氛下热封的电镀套件副本。 平板应储存在确保样品完整性的条件下，直至准备分发。 储存时间可能长达数年。 化合物编号：~600 化合物收集：肿瘤询问工具 浓度：10 mM 体积：1-10 uL（TBD） 摩尔：1-10 nM（TBD） 溶剂：DMSO 平板类型：Greiner 781280，384孔，一次性（或类似） 平板格式：TBD 此外，承包商应： 1)生成正确使用样本所需的电子平板图和任何其他描述性信息（例如，靶标/途径注释） 本任务订单将执行基本IDIQ合同的任务3。此外，该任务订单将是不可分割的成本补偿加固定费用。