Promotion and Prevention in the Treatment of Obesity

肥胖症治疗的促进和预防

• 批准号: 9298628
• 负责人: KATHRYN E DEMOS
• 金额: $ 7.3万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9298628
• 关键词: Address; Adherence; Aftercare; Agreement; Antismoking; Area; Behavior; Behavioral; Body Weight decreased; Brain; Brain imaging; Brain region; Calories; Clinical Treatment; Clinical Trials; Cognitive; Consumption; Data; Decision Making; Development; Eating; Educational process of instructing; Ensure; Environment; Exhibits; Food; Future; Goals; Happiness; Health; Health Food; Health behavior; Individual; Individual Differences; Internet; Intervention; Investigation; Lead; Learning; Measurement; Measures; Memory; Meta-Analysis; Methods; Monitor; Morbidity - disease rate; Obesity; Outcome; Overweight; Parents; Participant; Persons; Prevention; Prevention strategy; Public Health; Randomized; Recurrence; Research; Rewards; Role; Self-control as a personality trait; Taste Perception; Testing; Text; Thinking; Time; Training; United States; Weight; Weight Gain; Weight maintenance regimen; Woman; Work; arm; base; behavioral economics; career; craving; food consumption; food craving; healthy weight; improved; innovation; insight; men; mortality; neuroimaging; novel; obesity treatment; obesogenic; pleasure; prevent; programs; psychologic; smoking cessation; success; theories; weight loss intervention

Project Summary/Abstract Obesity is one of the most important public health issues today, contributing to many of the primary causes of morbidity and mortality in the United States. Still, treatment remains difficult and many people continually struggle to lose weight. Thus there is critical need for improvements in methods for treating obesity. One potential reason weight control is so difficult is the need to sacrifice immediate pleasures for long-term goals. This requires placing significant value on future outcomes, such as health. One strategy for doing so is to focus on the potential benefits of avoiding unhealthy choices. Health messaging studies suggest that messages focused on promoting long-term benefits of healthier choices may be effective in encouraging initiation of, or positive attitudes toward, healthy behaviors, however, longer-term effects of these messages have not been studied in the context of obesity. By contrast, behavioral economic work on Prospect Theory suggests focusing on preventing future negative consequences may be superior, and the threat of weight gain is a more powerful motivator than the benefit of weight loss. Although prevention strategies have been successfully employed in smoking cessation and anti-smoking campaigns, they are not typically used in obesity treatment. In promising preliminary neuroimaging work, we identified increases in brain regions involved in inhibitory control and decreases in cravings when using this PREVENT strategy. The goal of this R03 is to test whether an intervention built upon the goal to PREVENT long-term consequences of weight gain versus an intervention built upon the goal to PROMOTE long-term benefits of weight loss is beneficial in altering valuation of health and taste in food choice decision-making, encouraging adherence, reducing food cravings and consumption, and ultimate weight loss, as compared to a standard behavioral weight loss program (BWL). A total of 90 overweight/obese men and women will be randomly assigned to either PREVENT, PROMOTE, or standard BWL. Each intervention will have one in-person training session wherein participants will learn key strategies of their assigned program, and the remaining 12 weekly lessons will be delivered via internet. Baseline and 3-month (post-treatment) assessments will include the food choice decision-making task featured in the parent K01 to measure valuation of health and taste, weight measurement, and measurement of food cravings and consumption. To address feasibility, adherence and engagement measures (i.e., lessons viewed, self-monitoring) will be collected during the internet program, and memory for lesson content will be assessed post-treatment. Individual difference measures will also be collected to provide preliminary data on factors that may influence success in each arm. This project tests innovative approaches in the clinical treatment of obesity and will provide new insights into the potential role of prevention versus promotion strategies for weight loss, further establishing Dr. Demos' independent research career.

项目总结/文摘

项目成果

A randomized controlled trial comparing prevention and promotion cognitive strategies in a behavioral weight-loss intervention.

一项随机对照试验，比较行为减肥干预中的预防和促进认知策略。

• DOI: 10.1002/oby.23337
• 发表时间: 2022
• 期刊: Obesity (Silver Spring, Md.)
• 作者: DemosMcDermott,KathrynE;Leblond,TiffanyL;Dunsiger,ShiraI;Rothman,AlexanderJ;Wing,RenaR
• 通讯作者: Wing,RenaR