Novel Simulation Technologies for BHV Long-Term Durability

BHV 长期耐用性的新颖仿真技术

• 批准号: 9275533
• 负责人: Thomas J. Hughes
• 金额: $ 56.3万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-19 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9275533
• 关键词: Affect; Behavior; Biochemical; Biocompatible Materials; Biomechanics; Bioprosthesis device; Blood; Calcified; Cardiac; Cardiovascular system; Chemistry; Clinical; Code; Complex; Computer-Aided Design; Coupled; Coupling; Custom; Deterioration; Development; Devices; Elements; Engineering; Environment; Equipment Malfunction; Evaluation; Failure; Fatigue; Fiber; Finite Element Analysis; Formulation; Frequencies; Geometry; Glean; Goals; Heart Valve Prosthesis; Heart Valves; In Vitro; Liquid substance; Measures; Mechanics; Mediating; Methods; Modeling; Operative Surgical Procedures; Patients; Pattern; Performance; Pericardial body location; Periodicity; Physiological; Process; Shapes; Stents; Stress; Structure; System; Technology; Testing; Time; Tissues; Validation; Xenograft procedure; biomechanical model; calcification; computer framework; design; fluid flow; heart valve replacement; heart valve xenograft; hemodynamics; improved; insight; kinematics; mechanical behavior; mineralization; novel; operation; response; sample fixation; simulation; tool; validation studies; valve replacement

Summary: The most popular replacement heart valve designs (so called “bioprosthetic heart valves” or BHV) continue to be fabricated from xenograft biomaterials for both current and novel valve designs (e.g. standard stented valve, percutaneous delivery). Failure continues to be the result of leaflet structural deterioration mediated by fatigue and/or tissue mineralization, with durability limited to 10-15 years. Such limitations results from a combination of valve design and the intrinsic fatigue response of the constituent xenograft biomaterials. Thus, improved durability remains an important clinical goal and represents a unique cardiovascular engineering challenge resulting from the extreme valvular mechanical demands that occur with blood contact. Yet, current BHV assessment relies exclusively on device-level evaluations, which are confounded by simultaneous and highly coupled biomaterial mechanical behaviors and fatigue, valve design, hemodynamics, and calcification. Thus, despite decades of clinical BHV usage and growing popularity, there exists no acceptable method for simulating replacement valve function and durability at both the device and component biomaterial levels. This situation has contributed to the current stagnation in BHV development, limiting rationally developed improvements in prosthetic heart valve durability. We thus hypothesize that with the use of advanced biosolid mechanics simulations of the fatigue response of xenograft biomaterials coupled to state-of-the-art fluid-structure interaction (FSI) methods, a biomechanically rigorous and physiologically realistic approach to predict BHV performance can be developed. We will develop these coupled computational goals first in parallel, then combine and validate them in a final project stage.

摘要：最流行的置换心脏瓣膜设计（所谓的“生物假体”） 心脏瓣膜”或 BHV）继续由异种移植生物材料制造，用于 当前和新颖的瓣膜设计（例如标准支架瓣膜、经皮输送）。 失效仍然是疲劳介导的小叶结构恶化的结果 和/或组织矿化，耐久性仅限于 10-15 年。这样的限制 阀门设计和阀门固有疲劳响应相结合的结果 异种移植生物材料的组成部分。因此，提高耐用性仍然是一个重要的 临床目标并代表了由此产生的独特的心血管工程挑战 来自血液接触时发生的极端瓣膜机械需求。然而， 目前的 BHV 评估完全依赖于设备级评估，即 被同时且高度耦合的生物材料机械行为所混淆， 疲劳、瓣膜设计、血流动力学和钙化。因此，尽管几十年来 BHV 的临床使用和日益普及，目前尚无可接受的方法 模拟设备和组件的更换阀门功能和耐用性 生物材料水平。这种情况导致了 BHV 目前的停滞 发展，限制了人工心脏瓣膜的合理开发改进 耐用性。因此，我们假设通过使用先进的生物固体力学 与最先进技术相结合的异种移植生物材料的疲劳反应模拟 流固耦合 (FSI) 方法是一种严格的生物力学和生理学方法 可以开发预测 BHV 性能的现实方法。我们将开发 这些耦合的计算目标首先并行进行，然后在一个模型中组合并验证它们 最后项目阶段。