GENOME-WIDE IDENTIFICATION OF GENES REQUIRED FOR DECIDUALIZATION
蜕化所需基因的全基因组鉴定
基本信息
- 批准号:9258455
- 负责人:
- 金额:$ 19.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-04-08 至 2019-03-31
- 项目状态:已结题
- 来源:
- 关键词:BiologyBirthCell LineCellsCherry - dietaryClone CellsConceptusContraceptive methodsDecidual CellDecidual Cell ReactionsDefectEndometrial Stromal CellEventFactor AnalysisFailureFertilization in VitroFetal GrowthFibroblastsGenerationsGenesGeneticGrowth FactorHarvestHormonalHumanImplantIn VitroInfertilityLeadLibrariesPathway interactionsPlacentationPolyploidyPregnancyProceduresProcessProlactinProteinsReporterReproductionResearchSignal TransductionStromal CellsTimeTissuesUterusblastocystdeep sequencingenvironmental chemicalenvironmental toxicologyfailure Implantationgenome-widegenome-wide analysishigh throughput screeninghuman embryonic stem cellimplantationnatural Blastocyst Implantationnovelpromoterpublic health relevancered fluorescent proteinresponsescreeningsmall hairpin RNAtooltranscription factor
项目摘要
DESCRIPTION (provided by applicant): Human infertility is a global problem and failure of embryo implantation accounts for a significant percentage of pregnancy failure during both natural pregnancy and in vitro fertilization procedures. Implantation is an extremely complicated process requiring precisely controlled hormonal, growth factor signaling and cell-cell contacts which coordinate interactions between the competent blastocysts and the receptive uterus. Decidualization is part of the implantation process and involves rapid proliferation then differentiation of fibroblast-like endometrial stromal cells into epitheloid-like decidual cells whch later become part of the decidual tissue that surrounds the implanting conceptus. Decidualization defects can directly lead to implantation failure. In addition, early decidualizatin defects can also lead to other pregnancy defects such as placentation, intrauterine fetal growth, and parturition. Up to now, the process of decidualization has not been systematically studied due to the lack of a suitable high throughput screening tool. Here we describe the generation of such an in vitro screening tool that contains a fluorescent readout for decidualization. In Aim I we will use this in vitro screening tool to perform a genome-wide shRNA screen to identify novel genes for decidualization. In Aim II, we will analyze the temporal induction of transcription factors required for decidualization and establish a transcription factor network leading to decidualization. Successful completion of this project will have a long-lasting impact in multiple research fields including implantation biology, contraception, in vitro fertilization and environmental toxicology.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Liang Ma其他文献
Liang Ma的其他文献
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{{ truncateString('Liang Ma', 18)}}的其他基金
Androgen and Wnt signaling in bladder cancer
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10727745 - 财政年份:2023
- 资助金额:
$ 19.06万 - 项目类别:
GENERATION OF AN INDUCIBLE SYSTEM IN THE UTERINE STROMA FOR IMPLANTATION STUDIES
用于植入研究的子宫间质中诱导系统的生成
- 批准号:
8358586 - 财政年份:2012
- 资助金额:
$ 19.06万 - 项目类别:
GENERATION OF AN INDUCIBLE SYSTEM IN THE UTERINE STROMA FOR IMPLANTATION STUDIES
用于植入研究的子宫间质中诱导系统的生成
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8522211 - 财政年份:2012
- 资助金额:
$ 19.06万 - 项目类别:
Novel effectors of ERK signaling and their potential roles in the treatment of en
ERK 信号传导的新型效应物及其在治疗 en 中的潜在作用
- 批准号:
7727351 - 财政年份:2009
- 资助金额:
$ 19.06万 - 项目类别:
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