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Heart Failure Clinical Trials Network

心力衰竭临床试验网络

基本信息

批准号：
9198036
负责人：
ANDREW SMITH
金额：
$ 35.65万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-01-01 至 2018-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9198036
关键词：
Acute Address Admission activity Affect African American American Biochemical Biological Markers Biometry Blood Vessels Cardiac Volume Cardiology Cardiovascular system Caring Catecholamines Cessation of life Cities Clinical Clinical Research Clinical Trials Clinical Trials Design Clinical Trials Network Collaborations Communities Community Practice Community of Practice Conduct Clinical Trials Congestive Heart Failure Controlled Clinical Trials Data Data Coordinating Center Decision Making Diagnosis Discipline of Nursing Documentation Effectiveness of Interventions Electrophysiology (science)Eligibility Determination Emergency Medicine Employee Strikes Environment Equilibrium Ethics Evaluation Excretory function Faculty Fostering Functional disorder Gender Genetic Predisposition to Disease Genomics Geriatrics Goals Grant Guidelines Healthcare Heart failure Hospitalization Hospitals Human Resources Hydralazine Image Individual Informatics Institution Instruction Interdisciplinary Study Intervention Investigation Isosorbide Dinitrate Kidney Lung Medical Medicine Mentors Methodology Methods Minority National Heart, Lung, and Blood Institute Nephrology Neurology Nitric Oxide Nurses Operative Surgical Procedures Oral Outcome Oxidation-Reduction Oxidative Stress Palliative Care Patient-Focused Outcomes Patients Physicians Placebo Control Play Population Prevention Preventive Medicine Primary Health Care Public Health Publications Quality of life Race Radiology Specialty Randomized Reactive Oxygen Species Regenerative Medicine Rehabilitation therapy Research Research Infrastructure Research Personnel Research Technics Risk Role Science Signal Transduction Sleep Time Training Transplantation United States National Institutes of Health Universities Vasodilation Woman Work Writing base career career development cost effectiveness data sharing design evidence base hemodynamics human subject improved improved outcome interest knowledge base mortality nutrition patient population programs prospective protocol development response skill acquisition skills theories vasoconstriction

项目摘要

In this proposal, the Division of Cardiology at Emory University seeks to become a Regional Clinical Center (RCC) within NHLBI's Heart Failure (HF) Clinical Research Network, a network of centers with active HF programs interested in generating and promoting evidence-based HF practice. Herein, we describe our HF and related programs, collaborators, and related clinical and research programs and institutions, our research and other accomplishments, and our faculty and key personnel; we also provide evidence of our institutional and individual expertise in clinical trials in HF, as well as documentation of access to relevant patient populations including women and minorities, extraordinary volume of HF patients, and multidisciplinary collaboration in the proposed Emory RCC. We believe that the Emory University infrastructure and investigators are well-equipped to achieve the primary and secondary goals of the Network. If chosen as a RCC, the Emory team will work diligently to achieve the various aims for the Network. We also seek to develop and implement a Clinical Research Skills Development Core to assist new investigators in developing their research skills, thus taking advantage of the rich environment presented by the Network and build upon the core of well trained clinical researchers within cardiovascular medicine focused on HF. As an indication of our ability to conceive, design, and conduct clinical trials, we also propose a randomized, placebo-controlled clinical trial (Nitric Oxide induced Vasodilation Evaluation in acute HF - NOVEL-HF) to evaluate the efficacy of the oral combination of hydralazine plus isosorbide dinitrate (H-ISDN) in patients with HF due to systolic dysfunction admitted with acute decompensated HF (AHDF). This therapy is associated with hemodynamic benefits that could improve outcomes in ADHF based on observational data. Emory University has a longstanding commitment to diversity and the population mix in the city of Atlanta offers a rich environment to study the similarities and differences in treatment among diverse patient groups. We therefore propose a clinical trial to assess a key clinical question facing HF medicine today, i.e. the role of H- ISDN in ADHF, its benefits and mechanisms of action, and outcomes in black versus non-black HF patients.

在这项提案中，埃默里大学心脏病科寻求成为一个区域临床中心