Heart Failure Clinical Trials Network
Heart Failure Clinical Trials Network
批准号:
9198036
负责人:
ANDREW SMITH
金额:
$35.65万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-01-01 至 2018-12-31
关键词:
AcuteAddressAdmission activityAffectAfrican AmericanAmericanBiochemicalBiological MarkersBiometryBlood VesselsCardiac VolumeCardiologyCardiovascular systemCaringCatecholaminesCessation of lifeCitiesClinicalClinical ResearchClinical TrialsClinical Trials DesignClinical Trials NetworkCollaborationsCommunitiesCommunity PracticeCommunity of PracticeConduct Clinical TrialsCongestive Heart FailureControlled Clinical TrialsDataData Coordinating CenterDecision MakingDiagnosisDiscipline of NursingDocumentationEffectiveness of InterventionsElectrophysiology (science)Eligibility DeterminationEmergency MedicineEmployee StrikesEnvironmentEquilibriumEthicsEvaluationExcretory functionFacultyFosteringFunctional disorderGenderGenetic Predisposition to DiseaseGenomicsGeriatricsGoalsGrantGuidelinesHealthcareHeart failureHospitalizationHospitalsHuman ResourcesHydralazineImageIndividualInformaticsInstitutionInstructionInterdisciplinary StudyInterventionInvestigationIsosorbide DinitrateKidneyLungMedicalMedicineMentorsMethodologyMethodsMinorityNational Heart, Lung, and Blood InstituteNephrologyNeurologyNitric OxideNursesOperative Surgical ProceduresOralOutcomeOxidation-ReductionOxidative StressPalliative CarePatient-Focused OutcomesPatientsPhysiciansPlacebo ControlPlayPopulationPreventionPreventive MedicinePrimary Health CarePublic HealthPublicationsQuality of lifeRaceRadiology SpecialtyRandomizedReactive Oxygen SpeciesRegenerative MedicineRehabilitation therapyResearchResearch InfrastructureResearch PersonnelResearch TechnicsRiskRoleScienceSignal TransductionSleepTimeTrainingTransplantationUnited States National Institutes of HealthUniversitiesVasodilationWomanWorkWritingbasecareercareer developmentcost effectivenessdata sharingdesignevidence basehemodynamicshuman subjectimprovedimproved outcomeinterestknowledge basemortalitynutritionpatient populationprogramsprospectiveprotocol developmentresponseskill acquisitionskillstheoriesvasoconstriction
中文摘要
在这项提案中,埃默里大学心脏病科寻求成为一个区域临床中心
英文摘要
In this proposal, the Division of Cardiology at Emory University seeks to become a Regional Clinical Center
(RCC) within NHLBI's Heart Failure (HF) Clinical Research Network, a network of centers with active HF
programs interested in generating and promoting evidence-based HF practice. Herein, we describe our HF
and related programs, collaborators, and related clinical and research programs and institutions, our
research and other accomplishments, and our faculty and key personnel; we also provide evidence of our
institutional and individual expertise in clinical trials in HF, as well as documentation of access to relevant
patient populations including women and minorities, extraordinary volume of HF patients, and
multidisciplinary collaboration in the proposed Emory RCC. We believe that the Emory University infrastructure and
investigators are well-equipped to achieve the primary and secondary goals of the Network. If chosen as a
RCC, the Emory team will work diligently to achieve the various aims for the Network. We also seek to
develop and implement a Clinical Research Skills Development Core to assist new investigators in
developing their research skills, thus taking advantage of the rich environment presented by the Network and
build upon the core of well trained clinical researchers within cardiovascular medicine focused on HF. As an
indication of our ability to conceive, design, and conduct clinical trials, we also propose a randomized,
placebo-controlled clinical trial (Nitric Oxide induced Vasodilation Evaluation in acute HF - NOVEL-HF) to
evaluate the efficacy of the oral combination of hydralazine plus isosorbide dinitrate (H-ISDN) in patients with
HF due to systolic dysfunction admitted with acute decompensated HF (AHDF). This therapy is associated
with hemodynamic benefits that could improve outcomes in ADHF based on observational data. Emory
University has a longstanding commitment to diversity and the population mix in the city of Atlanta offers a
rich environment to study the similarities and differences in treatment among diverse patient groups. We
therefore propose a clinical trial to assess a key clinical question facing HF medicine today, i.e. the role of H-
ISDN in ADHF, its benefits and mechanisms of action, and outcomes in black versus non-black HF patients.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Heart Failure Clinical Trials Network
-
批准号:8600721
-
项目类别:
-
资助金额:$35.65万
-
财政年份:2012
-
负责人:ANDREW SMITH
-
依托单位:
MAINTAINING AND ENHANCING MAINE'S ENVIRONMENTAL PUBLIC HEALTH TRACKING PROGRAM
-
批准号:8275091
-
项目类别:
-
资助金额:$100.47万
-
财政年份:2011
-
负责人:ANDREW SMITH
-
依托单位:
PPHF-13-MAINTAINING & ENHANCING MAINE'S ENVIRONMENTAL PUB HLTH TRACKING PROGRAM
-
批准号:8520010
-
项目类别:
-
资助金额:$65.31万
-
财政年份:2011
-
负责人:ANDREW SMITH
-
依托单位:
MAINTAINING & ENHANCING MAINE'S ENVIRONMENTAL PUB HLTH TRACKING PROGRAM NETWORK
-
批准号:8852831
-
项目类别:
-
资助金额:$102.15万
-
财政年份:2011
-
负责人:ANDREW SMITH
-
依托单位:
MODEL MEMBRANES DISPLAYING COEXISTING LIQUID ORDERED AND DISORDERED PHASES
-
批准号:8363975
-
项目类别:
-
资助金额:$0.37万
-
财政年份:2011
-
负责人:ANDREW SMITH
-
依托单位:
DETERMINATION OF TIE-LINE FIELDS FOR COEXISTING LIPID PHASES
-
批准号:8364013
-
项目类别:
-
资助金额:$0.37万
-
财政年份:2011
-
负责人:ANDREW SMITH
-
依托单位:
Healthy Homes and Lead Poisoning Prevention Program
-
批准号:8249653
-
项目类别:
-
资助金额:$38.29万
-
财政年份:2011
-
负责人:ANDREW SMITH
-
依托单位:
PPHF-12-MAINTAINING & ENHANCING MAINE'S ENVIRONMENTAL PUB HLTH TRACKING PROGRAM
-
批准号:8321835
-
项目类别:
-
资助金额:$100.47万
-
财政年份:2011
-
负责人:ANDREW SMITH
-
依托单位:
DYNAMIC STRUCTURE OF L-O AND L-D PHASES IN SPM-DOPC-CHOLESTEROL BY ESR
-
批准号:8363990
-
项目类别:
-
资助金额:$0.37万
-
财政年份:2011
-
负责人:ANDREW SMITH
-
依托单位:
DETERMINATION OF TIE-LINE FIELDS FOR COEXISTING LIPID PHASES
-
批准号:8172173
-
项目类别:
-
资助金额:$0.29万
-
财政年份:2010
-
负责人:ANDREW SMITH
-
依托单位:
BUILDING CAPACITY TO IMPLEMENT CLIMATE CHANGE PROGRAMS AND ADAPTATIONS IN MAINE
-
批准号:8292873
-
项目类别:
-
资助金额:$24.97万
-
财政年份:2010
-
负责人:ANDREW SMITH
-
依托单位:
MODEL MEMBRANES DISPLAYING COEXISTING LIQUID ORDERED AND DISORDERED PHASES
-
批准号:8172113
-
项目类别:
-
资助金额:$0.29万
-
财政年份:2010
-
负责人:ANDREW SMITH
-
依托单位:
DYNAMIC STRUCTURE OF L-O AND L-D PHASES IN SPM-DOPC-CHOLESTEROL BY ESR
-
批准号:8172135
-
项目类别:
-
资助金额:$0.29万
-
财政年份:2010
-
负责人:ANDREW SMITH
-
依托单位:
BUILDING CAPACITY TO IMPLEMENT CLIMATE CHANGE PROGRAMS AND ADAPTATIONS IN MAINE
-
批准号:8131582
-
项目类别:
-
资助金额:$24.97万
-
财政年份:2010
-
负责人:ANDREW SMITH
-
依托单位:
BUILDING CAPACITY TO IMPLEMENT CLIMATE CHANGE PROGRAMS AND ADAPTATIONS IN MAINE
-
批准号:8067551
-
项目类别:
-
资助金额:$23.35万
-
财政年份:2010
-
负责人:ANDREW SMITH
-
依托单位:
MODEL MEMBRANES DISPLAYING COEXISTING LIQUID ORDERED AND DISORDERED PHASES
-
批准号:7956631
-
项目类别:
-
资助金额:$0.36万
-
财政年份:2009
-
负责人:ANDREW SMITH
-
依托单位:
DYNAMIC STRUCTURE OF L-O AND L-D PHASES IN SPM-DOPC-CHOLESTEROL BY ESR
-
批准号:7956655
-
项目类别:
-
资助金额:$0.36万
-
财政年份:2009
-
负责人:ANDREW SMITH
-
依托单位:
DETERMINATION OF TIE-LINE FIELDS FOR COEXISTING LIPID PHASES
-
批准号:7956693
-
项目类别:
-
资助金额:$0.36万
-
财政年份:2009
-
负责人:ANDREW SMITH
-
依托单位:
DYNAMIC STRUCTURE OF L-O AND L-D PHASES IN SPM-DOPC-CHOLESTEROL BY ESR
-
批准号:7723962
-
项目类别:
-
资助金额:$0.15万
-
财政年份:2008
-
负责人:ANDREW SMITH
-
依托单位:
MODEL MEMBRANES DISPLAYING COEXISTING LIQUID ORDERED AND DISORDERED PHASES
-
批准号:7723938
-
项目类别:
-
资助金额:$0.1万
-
财政年份:2008
-
负责人:ANDREW SMITH
-
依托单位:
海外基金