APPLIED RESEARCH

应用研究

基本信息

  • 批准号:
    9358156
  • 负责人:
  • 金额:
    $ 7.24万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-08-15 至 2022-05-31
  • 项目状态:
    已结题

项目摘要

APPLIED RESEARCH – Project Summary The Specific Pathogen Free Baboon Research Resource (SPFBRR) is a scientifically unique colony of Old World research primates that are free of 19 adventitious infectious agents that are commonly found in conventional baboon species. The applied research that is proposed in this grant application has been developed to strengthen and improve the resource. The first two specific aims include the development and implementation of 7 molecular diagnostic assays for retroviruses and herpesviruses that are already on the bioexclusion list, and a novel arterivirus that has recently been identified in research baboons. Application of these assays will allow us to identify incipient infections in nursery-raised animals sooner, thus decreasing the attrition rate from the nursery. The next two projects involve genomic sequencing efforts to further define the animals within the SPFBRR and to improve the quality of research studies. The first of these genetics projects is to sequence the major histocompatibility complex (MHC) class I mRNA transcripts of all of the breeding animals in the SPFBRR to identify the complete repertoire of MHC class I genes. This information will allow us to perform MHC class I genotypes on all progeny animal in the colony to better inform future research studies. The second genetics project will be to perform whole genome sequencing (WGS) on 26 animals from the SPFBRR: the genomes of all 13 male breeders and one offspring from each of them will be sequenced. This information will allow us to calculate a 7 to 8 generation genomic pedigree analysis to better manage future colony breeding genetics, and it will also allow us to search for functionally significant genetic variations that could help to direct and inform future research projects. The final applied research project is a pilot study to use female retired breeder beagles as surrogates for nursery-raised baboons. The goal of this project is to provide some additional “maternal” contact to ensure behaviorally normal adult baboons for the SPF breeding colony.
应用研究-项目摘要

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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CHRISTIAN R ABEE其他文献

CHRISTIAN R ABEE的其他文献

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{{ truncateString('CHRISTIAN R ABEE', 18)}}的其他基金

CHIMPANZEE BIOMEDICAL RESEARCH RESOURCE
黑猩猩生物医学研究资源
  • 批准号:
    8356918
  • 财政年份:
    2011
  • 资助金额:
    $ 7.24万
  • 项目类别:
ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: GENOME
建立
  • 批准号:
    8173568
  • 财政年份:
    2010
  • 资助金额:
    $ 7.24万
  • 项目类别:
ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: IMMUNOLOGY
建立
  • 批准号:
    8173569
  • 财政年份:
    2010
  • 资助金额:
    $ 7.24万
  • 项目类别:
CHIMPANZEE BIOMEDICAL RESEARCH PROGRAM: VACCINE DVMT
黑猩猩生物医学研究计划:疫苗 DVMT
  • 批准号:
    8173572
  • 财政年份:
    2010
  • 资助金额:
    $ 7.24万
  • 项目类别:
ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: THERAPEUTIC AGENT DVMT
建立
  • 批准号:
    8173571
  • 财政年份:
    2010
  • 资助金额:
    $ 7.24万
  • 项目类别:
ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: ANIMAL MODEL
建立
  • 批准号:
    8173570
  • 财政年份:
    2010
  • 资助金额:
    $ 7.24万
  • 项目类别:
ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: THERAPEUTIC AGENT DVMT
建立
  • 批准号:
    7961230
  • 财政年份:
    2009
  • 资助金额:
    $ 7.24万
  • 项目类别:
ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: GENOME
建立
  • 批准号:
    7961227
  • 财政年份:
    2009
  • 资助金额:
    $ 7.24万
  • 项目类别:
ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: ANIMAL MODEL
建立
  • 批准号:
    7961229
  • 财政年份:
    2009
  • 资助金额:
    $ 7.24万
  • 项目类别:
CHIMPANZEE BIOMEDICAL RESEARCH PROGRAM: VACCINE DVMT
黑猩猩生物医学研究计划:疫苗 DVMT
  • 批准号:
    7961231
  • 财政年份:
    2009
  • 资助金额:
    $ 7.24万
  • 项目类别:

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