ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: IMMUNOLOGY

建立

• 批准号: 8173569
• 负责人: CHRISTIAN R ABEE
• 金额: $ 56.54万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173569
• 关键词: Acquired Immunodeficiency Syndrome; Age; Awareness; Biohazardous Substance; Biomedical Research; Breeding; Cancer Center; Caring; Charge; Clinical Pathology; Clinical Trials; Complement; Computer Retrieval of Information on Scientific Projects Database; Country; Doctor of Medicine; Equilibrium; Funding; Genetic; Grant; Habitats; Health; Housing; Human Resources; Immunology; Individual; Institution; Investigation; Mission; Modeling; Pan Genus; Peer Review; Personal Satisfaction; Positive Reinforcements; Procedures; Research; Research Personnel; Research Support; Resources; Services; Source; Training Technics; U-Series Cooperative Agreements; United States National Institutes of Health; Viral; abstracting; cost effective; design; expectation; experience; flexibility; improved; meetings; molecular array; programs; success; veterinary science

DESCRIPTION (provided by applicant): This is a revised competitive renewal application of a cooperative agreement titled the "Chimpanzee Biomedical Research Resource" (CBRP). The CBRP is maintained at the Michale E. Keeling Center for Comparative Medicine and Research (KCCMR) of The UT M. D. Anderson Cancer Center in Bastrop, TX and the Primate Foundation of Arizona (PFA) in Mesa, AZ. The primary activity site is the KCCMR with a colony of 103 chimpanzees. The PFA maintains a colony of 61. The use of two sites provides security against disease outbreaks and natural disasters that could jeopardize the resource. Additionally, PFA maintains the only research naive chimpanzee research resource in the US. With recent scientific advances such as the publication of the initial sequence of the chimpanzee genome, it has been determined with certainty that chimpanzees share more than 98% of our DNA and almost all of our genes. The CBRP is one of only four NCRR-supported centers with the capability to conduct biomedical research in this species. Over the past 30years, the CBRP has developed the highly specialized housing facilities, laboratories, management techniques and staff essential for conducting research using chimpanzees. Historically, the CBRP's efforts were focused on colony care and maintenance. Although this remains a primary objective, this revised renewal application presents a new approach that will enhance the research value of chimpanzees. We will expand activities to include the development of a website with information to help scientists determine if the chimpanzee is a relevant model for their studies. We will also make available chimpanzee-derived cell lines, antibodies and other biological materials, and establish a registry of biologic reagents that are known to work in the chimpanzee. Resource-related research will characterize the immune system of the chimpanzee, expand our understanding of chimpanzee cardiomyopathy as a potential disease model, and compare the physiologic and immunologic consequences of research manipulations on chimpanzees trained to voluntarily cooperate with research procedures versus untrained chimpanzees that must be anesthetized. We will accomplish these goals while implementing a new business plan aimed at reducing NCRR core support. By expanding the resources available, conducting resource-related research, and containing cost, the CBRP will provide a critically important, highly specialized, research resource to address human health issues.

描述(由申请人提供)：这是一份名为“黑猩猩生物医学研究资源”(CBRP)的合作协议的修订后的竞争性续签申请。CBRP由德克萨斯州巴斯特罗普的UT M.D.安德森癌症中心的米歇尔·E·基林比较医学和研究中心(KCCMR)和亚利桑那州梅萨的亚利桑那州灵长类基金会(PFA)维护。主要的活动地点是KCCMR，有103只黑猩猩。PFA维持着61人的殖民地。两个地点的使用提供了防止疾病暴发和可能危及资源的自然灾害的安全。此外，PFA还维护着美国唯一的研究幼稚的黑猩猩研究资源。随着最近的科学进步，如黑猩猩基因组初始序列的公布，人们已经肯定地确定，黑猩猩拥有超过98%的DNA和几乎所有的基因。CBRP是NCRR支持的仅有的四个有能力对该物种进行生物医学研究的中心之一。在过去的30年里，CBRP开发了高度专业化的住房设施、实验室、管理技术和工作人员，这些都是利用黑猩猩进行研究所必需的。从历史上看，CBRP的工作重点是殖民地的照顾和维护。尽管这仍然是一个主要目标，但这次修订后的续签申请提出了一种新的方法，将提高黑猩猩的研究价值。我们将扩大活动，包括开发一个网站，提供信息，帮助科学家确定黑猩猩是否为他们研究的相关模型。我们还将提供黑猩猩来源的细胞系、抗体和其他生物材料，并建立已知在黑猩猩身上起作用的生物试剂的登记。与资源相关的研究将描述黑猩猩的免疫系统，扩大我们对黑猩猩心肌病作为一种潜在疾病模型的理解，并比较研究操纵对训练为自愿配合研究程序的黑猩猩和必须麻醉的未经训练的黑猩猩的生理和免疫学后果。我们将在实施旨在减少NCRR核心支持的新业务计划的同时实现这些目标。通过扩大可用资源，开展与资源相关的研究，并控制成本，CBRP将为解决人类健康问题提供至关重要的、高度专业化的研究资源。