CHIMPANZEE BIOMEDICAL RESEARCH PROGRAM: VACCINE DVMT

描述（由申请人提供）：这是一份名为“黑猩猩生物医学研究资源”（CBRP）的合作协议的修订竞争性续期申请。CBRP由德克萨斯州巴斯托普的UT m.d.安德森癌症中心的迈克尔E.基林比较医学与研究中心（KCCMR）和亚利桑那州梅萨的灵长类动物基金会（PFA）维护。主要活动地点是KCCMR，有103只黑猩猩。PFA维持着61个种群。使用两个站点可以防止可能危及资源的疾病爆发和自然灾害。此外，PFA保持着美国唯一的研究幼稚黑猩猩的研究资源。随着最近的科学进步，例如黑猩猩基因组的初始序列的公布，已经确定黑猩猩与我们有98%以上的DNA和几乎所有的基因相同。CBRP是仅有的四个ncrr支持的有能力对该物种进行生物医学研究的中心之一。在过去的30年里，CBRP开发了高度专业化的住房设施、实验室、管理技术和工作人员，这些都是进行黑猩猩研究所必需的。从历史上看，CBRP的工作主要集中在群体的护理和维护上。虽然这仍然是一个主要目标，但这一修订后的更新申请提出了一种新的方法，将提高黑猩猩的研究价值。我们将扩大活动范围，包括建立一个网站，提供信息，帮助科学家确定黑猩猩是否是他们研究的相关模型。我们还将提供黑猩猩来源的细胞系、抗体和其他生物材料，并建立已知对黑猩猩起作用的生物试剂登记册。资源相关的研究将描述黑猩猩免疫系统的特征，扩大我们对黑猩猩心肌病作为一种潜在疾病模型的理解，并比较研究操作对黑猩猩的生理和免疫后果，这些黑猩猩经过训练后自愿配合研究程序，而未经训练的黑猩猩必须被麻醉。我们将在实现这些目标的同时，实施一项旨在减少NCRR核心支持的新业务计划。通过扩大现有资源，开展与资源有关的研究，并控制成本，CBRP将为解决人类健康问题提供一个极其重要的、高度专业化的研究资源。

DESCRIPTION (provided by applicant): This is a revised competitive renewal application of a cooperative agreement titled the "Chimpanzee Biomedical Research Resource" (CBRP). The CBRP is maintained at the Michale E. Keeling Center for Comparative Medicine and Research (KCCMR) of The UT M. D. Anderson Cancer Center in Bastrop, TX and the Primate Foundation of Arizona (PFA) in Mesa, AZ. The primary activity site is the KCCMR with a colony of 103 chimpanzees. The PFA maintains a colony of 61. The use of two sites provides security against disease outbreaks and natural disasters that could jeopardize the resource. Additionally, PFA maintains the only research naive chimpanzee research resource in the US. With recent scientific advances such as the publication of the initial sequence of the chimpanzee genome, it has been determined with certainty that chimpanzees share more than 98% of our DNA and almost all of our genes. The CBRP is one of only four NCRR-supported centers with the capability to conduct biomedical research in this species. Over the past 30years, the CBRP has developed the highly specialized housing facilities, laboratories, management techniques and staff essential for conducting research using chimpanzees. Historically, the CBRP's efforts were focused on colony care and maintenance. Although this remains a primary objective, this revised renewal application presents a new approach that will enhance the research value of chimpanzees. We will expand activities to include the development of a website with information to help scientists determine if the chimpanzee is a relevant model for their studies. We will also make available chimpanzee-derived cell lines, antibodies and other biological materials, and establish a registry of biologic reagents that are known to work in the chimpanzee. Resource-related research will characterize the immune system of the chimpanzee, expand our understanding of chimpanzee cardiomyopathy as a potential disease model, and compare the physiologic and immunologic consequences of research manipulations on chimpanzees trained to voluntarily cooperate with research procedures versus untrained chimpanzees that must be anesthetized. We will accomplish these goals while implementing a new business plan aimed at reducing NCRR core support. By expanding the resources available, conducting resource-related research, and containing cost, the CBRP will provide a critically important, highly specialized, research resource to address human health issues.