Mechanisms of Risk and Resilience in Adolescent Drug Treatment and Recovery

项目摘要/摘要 青少年物质使用障碍(SUDS)是一个重大的公共卫生问题。 青少年在接受SUD治疗后复发率很高，甚至高于成年人。 尽管人们对青少年发育的风险和韧性途径了解很多 关于成功与不成功的预测因素和机制，我们所知的要少得多 青少年的SUD治疗。一种在预测贫困人口方面显示出希望的机制 成人的治疗结果是高度痛苦不耐受(DI)：无能力或被认为无能力 以承受痛苦的情绪。拟议的研究侧重于直接投资的基线水平，因为 以及在现有住院和重症门诊患者期间和之后DI的变化 针对青少年的治疗方案。大约134名青少年将完成一项 对DI的全面评估，包括自我报告、生理测量和DI 治疗期间任务3次，6个月随访期间任务3次。 青少年和父母也将完成对已知的风险因素的评估 肥皂水的发展和维持，包括青少年和家庭药物使用史， 同伴药物使用、父母监控、社会支持、创伤症状和 内化/外化问题。在治疗和随访期间，青少年将报告他们的 物质渴求程度和物质使用复发。根据参与者的基线DI和 DI随时间的变化，结合其他测量的风险因素，结果建议 研究将被用来预测渴望程度和未来的复发。具体地说，结果将 在受试者内部和受试者之间提供基于DI的复发风险青少年的概况。 此外，由于科目内的多项评估，拟议的 研究可以通过演示基于依赖注入的干预何时可能 成为最需要的或最有益的。最后，根据《区域》的主要目标 R15计划，学生将获得宝贵的经验，在严谨和深入的研究 成瘾、改变机制和康复领域。学生们将参加 执行研究方案、数据分析、手稿准备和研究 在会议上发表演讲，加强学生未来的职业前景，以及 改善大学的研究环境。

PROJECT SUMMARY/ABSTRACT Adolescent substance use disorders (SUDs) present a significant public health concern. Adolescents have high rates of relapse following SUD treatment, higher even than adults. Although much is known about risk and resilience pathways for the development of adolescent SUDs, much less is known about predictors and mechanisms of successful versus unsuccessful SUD treatment in adolescents. One mechanism that has shown promise in predicting poor treatment outcomes for adults is high distress intolerance (DI): the inability or perceived inability to withstand distressing emotions. The proposed research focuses on baseline levels of DI, as well as change in DI during and following an existing residential and intensive outpatient treatment program for adolescents. Approximately 134 adolescents will complete a comprehensive assessment of DI, including self-reports, physiological measurements, and DI tasks at baseline, 3 times during treatment, and 3 times during the 6-month follow-up period. Adolescents and parents will also complete assessments of known risk factors for the development and maintenance of SUDs, including adolescent and family substance use history, peer substance use, parental monitoring, social support, trauma symptoms, and internalizing/externalizing problems. During treatment and follow-up, adolescents will report their level of substance craving and substance use relapses. Based on participants' baseline DI and DI change over time, in combination with other measured risk factors, results of the proposed research will be used to predict levels of craving and future relapse. Specifically, results will provide within- and between-subjects profiles of adolescents at risk for a DI-based relapse. Further, because of the multiple assessments within subjects, the results of the proposed research can inform future interventions by demonstrating when a DI-based intervention might be the most needed or beneficial. Finally, in accordance with the key objectives of the AREA R15 program, students will gain invaluable experience in rigorous and intensive research in the areas of addictions, change mechanisms, and recovery. Students will participate in the implementation of research protocols, data analysis, manuscript preparation, and research presentations at conferences, strengthening the students' future career prospects, as well as enhancing the university's research environment.