Center for Biomedical Research Excellence in Pathogen-Host Interactions

病原体-宿主相互作用生物医学卓越研究中心

• 批准号: 9302450
• 负责人: STEPHEN B PRUETT
• 金额: $ 176.72万
• 依托单位: MISSISSIPPI STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9302450
• 关键词: Accountability; Address; Advisory Committees; Agriculture; Area; Basic Science; Bioinformatics; Biology; Biomedical Research; Categories; Centers of Research Excellence; Collaborations; Committee Members; Communicable Diseases; Communication; Core Facility; Critiques; Development; Elements; Engineering; Equipment; Expenditure; Extramural Activities; Faculty; Forestry; Fostering; Foundations; Funding; Future Teacher; Goals; Grant; Growth; Health; Health Promotion; Human; Idaho; Institution; Investigation; Laboratories; Leadership; Letters; Listeria monocytogenes; Mentors; Methods; Mission; Mississippi; Molecular; Ownership; Paper; Participant; Play; Positioning Attribute; Preparation; Probability; Productivity; Program Description; Public Health; Publishing; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Role; Science; Shigella; Staphylococcus aureus; Strategic Planning; Streptococcus pneumoniae; Systems Biology; Time; Training; Translating; United States National Institutes of Health; Universities; Veterinarians; Veterinary Medicine; Work; career development; college; design; expectation; improved; influenzavirus; innovation; interest; member; pathogen; programs; public health relevance; success; synergism; virtual

DESCRIPTION (provided by applicant): A Center of Biomedical Research Excellence (COBRE) in Pathogen-Host Interactions at Mississippi State University is proposed here. This Center's most innovative component is that all of the junior investigator projects feature hypothesis driven studies to determine molecular mechanisms of pathogen-host interactions using, but all projects also include a systems biology component that will move each of the specific fields under investigation forward in a greater than incremental manner. This COBRE will establish infrastructure such as priority access to an existing Core facility (Omics Biology Lab) and a new virtual core that unifies the most commonly used major equipment in an easily accessible unit. All external and internal mentors reviewed the Junior Investigator projects. The External and Internal Advisory Committee members reviewed and critiqued the overall plan and the administrative core. All of the participants in this COBRE have published at least one paper or have already established a collaboration with another COBRE member, demonstrating that this is a natural team and not a team contrived only for this application. The leadership team and advisory committees for this COBRE have developed a plan for mentoring and accountability that will maximize the probability that the junior investigators will graduate to independent status. The External Advisory Committee includes the P.I. of a nearby COBRE that has graduated 8 R01-funded investigators. The goal of this COBRE is to produce teams that will successfully compete for extramural funding over an extended period of time and will be nationally prominent in their field of investigation. National prominence has already been achieved here in bioinformatics of agricultural species (see, for example, www.agbase.msstate.edu), and this COBRE will be used to leverage this success and apply it to research that is directly related to human health. The topics included in this COBRE represent a wide range of important human pathogens {Streptococcus pneumoniae, influenza virus, Shigella species, Listeria monocytogenes, and Staphylococcus aureus). We expect the combined reductionist and global approach in this COBRE to produce significant progress in research on these pathogens.

描述（由申请人提供）：此处提议在密西西比州立大学建立病原体-宿主相互作用生物医学卓越研究中心 (COBRE)。该中心最具创新性的部分是，所有初级研究员项目都以假设驱动的研究为特色，以确定病原体与宿主相互作用的分子机制，但所有项目还包括系统生物学部分，它将以大于增量的方式推动所研究的每个特定领域向前发展。该 COBRE 将建立基础设施，例如优先访问现有核心设施（组学生物学实验室）和新的虚拟核心，将最常用的主要设备统一在一个易于访问的单元中。所有外部和内部导师都审查了初级研究员项目。外部和内部咨询委员会成员对总体计划和行政核心进行了审查和批评。该 COBRE 的所有参与者都发表了至少一篇论文，或者已经与其他 COBRE 成员建立了合作关系，表明这是一个自然的团队，而不是专门为此应用而设计的团队。 COBRE 的领导团队和咨询委员会制定了一项指导和问责计划，该计划将最大限度地提高初级研究人员晋升为独立地位的可能性。外部咨询委员会包括 P.I.附近的 COBRE 已毕业 8 名由 R01 资助的调查员。 COBRE 的目标是培养能够在较长时间内成功竞争外部资金并在其调查领域处于全国领先地位的团队。农业物种生物信息学领域已经在全国范围内取得了显着的成就（例如，参见 www.agbase.msstate.edu），COBRE 将用于利用这一成功并将其应用于与人类健康直接相关的研究。本 COBRE 中包含的主题代表了多种重要的人类病原体（肺炎链球菌、流感病毒、志贺氏菌、单核细胞增多性李斯特菌和金黄色葡萄球菌）。我们期望 COBRE 中的综合还原论和全局方法能够在这些病原体的研究中取得重大进展。