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Center of Biomedical Research Excellence in Pathogen Host Interactions

病原体宿主相互作用生物医学卓越研究中心

基本信息

批准号：
10470185
负责人：
STEPHEN B PRUETT
金额：
$ 214.08万
依托单位：
MISSISSIPPI STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10470185
关键词：
Address Advisory Committees American Antibiotic Resistance Antibiotics Area Award Basic Science Biological Biomedical Research Centers for Disease Control and Prevention (U.S.)Centers of Research Excellence Characteristics Collaborations Communicable Diseases Communities Development Equipment Extramural Activities Faculty Foundations Funding Goals Grant Home Investigation Investments Laboratories Lead Leadership Mentors Metabolic Microbe Microbial Biofilms Mississippi Phase Pilot Projects Productivity Research Research Infrastructure Research Personnel Research Project Grants Resistance Role Safety Science Scientist Staphylococcus aureus System United States Department of Agriculture United States National Institutes of Health Universities Vaccines Vector-transmitted infectious disease Vendor Veterinary Medicine Virulence Work Writing antimicrobial drug cohesion college commercialization field study improved interest member microbial novel pathogen programs recruit square foot synergism translational potential

项目摘要

Overall Abstract The Phase I COBRE at Mississippi State University (MSU) has catalyzed a transformation in the biomedical research enterprise, particularly in the research focus area of the COBRE, pathogen-host interactions. In the CVM Basic Sciences Department, where most COBRE investigators worked, the research culture has changed; 19 of 20 faculty members now have competitive extramural funding. Furthermore, the total NIH funding amount at Mississippi State University has increased from about $1.4 million in 2012 (just before the Phase I COBRE began) to about $5.4 million in 2016 (year 4 of the Phase I COBRE). Two of our Phase I investigators have graduated to independent status, and all have obtained significant levels of competitive extramural funding. In fact, these two independent Phase I investigators will serve on the Leadership Team in Phase II, which will continue relationships between Phase I and Phase II investigators to build functional teams that will be competitive for collaborative funding efforts. Continuing the transformation of biomedical research at MSU to yield a self-sustaining high level research enterprise is the goal of the Phase II COBRE described in this application. We have identified 5 excellent investigators (two of whom were hired during Phase I) to lead research projects in the Phase II COBRE. The projects include sufficient commonality to allow synergy, and all are novel and have the potential to open new avenues of investigation. For example, two projects focus on vector borne diseases, three projects investigate the role of microbial metabolic adaptations in virulence, and two projects involve Staphylococcus aureus. One of the most positive characteristics of our investigators is the spontaneous development of collaborations between Phase I and Phase II investigators, which has occurred even before the beginning of Phase II. Plans for Phase II take advantage of this by deliberately encouraging continued interactions between Phase I and Phase II investigators both in mentoring and in research collaboration. Each investigator in Phase II has identified a distinguished scientist who is a leader in his/her field of study to serve as an external mentor. Internal mentors (from MSU) will serve as advisors in both scientific areas and in grant writing. All members of the distinguished External Advisory Committee from Phase I have agreed to serve in the same role in Phase II. With funds from Phase I, physical facilities and research infrastructure have been substantially improved by purchase of major equipment, renovation of the HVAC system of 4 labs, and addition of 6 Biological Safety Cabinets. The support of MSU for research in pathogen-host interactions is also illustrated by the university’s substantial investment to acquire a BSL-3 modular lab (1200 square feet with 3 separate labs), which has been commissioned and should be operational by the summer of 2018. A major user will be one of our COBRE Phase I investigators. The proposed Phase II COBRE will allow initiatives begun in Phase I to continue and establish a critical mass of well-funded investigators who can conduct high impact research.

总体摘要密西西比州立大学 (MSU) 的 I 期 COBRE 催化了生物医学领域的变革研究事业，特别是 COBRE 病原体与宿主相互作用的研究重点领域。在 CVM 基础科学部是大多数 COBRE 研究人员工作的地方，其研究文化已经改变了； 20 名教职人员中有 19 名拥有有竞争力的校外资助。此外，NIH 总密西西比州立大学的资助金额从 2012 年的约 140 万美元增加（就在第一阶段 COBRE 开始）到 2016 年（第一阶段 COBRE 的第四年）约为 540 万美元。我们第一阶段的两个调查人员已晋升为独立地位，并且所有人都获得了显着的竞争水平外部资金。事实上，这两名独立的第一阶段研究人员将在领导团队中任职第二阶段，将继续第一阶段和第二阶段研究人员之间的关系，以建立职能团队这对于合作资助工作来说将具有竞争力。持续推进生物医学研究转型在 MSU 建立一个自我维持的高水平研究企业是第二阶段 COBRE 的目标，该目标描述于这个应用程序。我们已经确定了 5 名优秀的研究者（其中两人是在第一阶段聘用的）来领导 COBRE 第二阶段的研究项目。这些项目具有足够的通用性以实现协同作用，并且所有新颖，有潜力开辟新的调查途径。例如，两个项目专注于媒介传播疾病，三个项目研究微生物代谢适应在毒力中的作用，以及两个项目涉及金黄色葡萄球菌。我们的调查人员最积极的特征之一是第一阶段和第二阶段研究人员之间的合作自发发展，已经发生甚至在第二阶段开始之前。第二阶段计划利用这一点，刻意鼓励第一阶段和第二阶段研究人员在指导和研究方面持续互动合作。第二阶段的每位研究者都指定了一位杰出的科学家，他/她是其领域的领导者担任外部导师的研究领域。内部导师（来自密歇根州立大学）将担任这两个方面的顾问科学领域和资助写作。尊敬的外部咨询委员会的所有成员第一阶段已同意在第二阶段担任相同的角色。凭借一期资金、物质设施和通过购置主要设备、更新改造科研基础设施，科研基础设施得到显着改善。 4 个实验室的 HVAC 系统，并增加了 6 个生物安全柜。密歇根州立大学对研究的支持该大学投入大量资金购买 BSL-3 也说明了病原体与宿主之间的相互作用模块化实验室（1200 平方英尺，有 3 个独立实验室），已投入运行并应可运行到 2018 年夏天。主要用户将是我们的 COBRE 一期研究人员之一。拟议的第二阶段 COBRE 将允许第一阶段开始的举措得以继续，并建立足够数量的资金充足的项目能够进行高影响力研究的研究人员。

项目成果

期刊论文数量（75）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Therapeutics and delivery vehicles for local treatment of osteomyelitis.

DOI：
10.1002/jor.24689
发表时间：
2020-10
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
0
作者：
Cobb LH;McCabe EM;Priddy LB
通讯作者：
Priddy LB

Controllable In Situ Transformation of Layered Double Hydroxides into Ultrathin Metal-Organic Framework Nanosheet Arrays for Energy Storage.

DOI：
10.1021/acs.inorgchem.1c03087
发表时间：
2022-02
期刊：
Inorganic chemistry
影响因子：
4.6
作者：
Yuanyuan Ling;Yingchao Wang;Wen-Na Zhao;Jiachao Zhou;Kangye Chen;K. Tao;L. Han
通讯作者：
Yuanyuan Ling;Yingchao Wang;Wen-Na Zhao;Jiachao Zhou;Kangye Chen;K. Tao;L. Han

Effect of Treated Time of Hydrothermal Etching Process on Oxide Layer Formation and Its Antibacterial Properties.

DOI：
10.3390/biomimetics7030091
发表时间：
2022-07-07
期刊：
Biomimetics (Basel, Switzerland)
影响因子：
0
作者：
通讯作者：

Scarcity of Hepatozoon americanum in Gulf Coast tick vectors and potential for cultivating the protozoan.

DOI：
10.1016/j.vprsr.2020.100421
发表时间：
2020-07
期刊：
VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS
影响因子：
1.4
作者：
Parkins, Natalie D.;Stokes, John, V;Gavron, Nancy A.;Frankovich, Alexandra N.;Varela-Stokes, Andrea S.
通讯作者：
Varela-Stokes, Andrea S.

No-boundary thinking: a viable solution to ethical data-driven AI in precision medicine.