Center for Biomedical Research Excellence in Pathogen-Host Interactions

描述（由申请人提供）：这里提议在密西西比州立大学建立一个病原体-宿主相互作用的生物医学研究卓越中心（COBRE）。该中心最具创新性的组成部分是，所有的初级研究员项目都以假设驱动的研究为特征，以确定病原体-宿主相互作用的分子机制，但所有项目都包括系统生物学部分，该部分将以大于增量的方式推动每个特定领域的研究。该COBRE将建立基础设施，例如优先访问现有的核心设施（组学生物实验室）和一个新的虚拟核心，将最常用的主要设备统一在一个易于访问的单元中。所有外部和内部导师都审查了初级研究员项目。外部和内部咨询委员会成员审查并批评了总体计划和行政核心。本次COBRE的所有参与者都至少发表了一篇论文，或者已经与另一位COBRE成员建立了合作关系，这表明这是一个自然的团队，而不是一个只为这个应用程序而设计的团队。该协调机构的领导小组和咨询委员会制定了一项指导和问责计划，将最大限度地提高初级调查员逐步成为独立调查员的可能性。外部咨询委员会包括PI。附近一家COBRE的研究员，他们已经毕业了8名R 01资助的研究员。该COBRE的目标是产生将在很长一段时间内成功竞争校外资金的团队，并将在其调查领域成为全国知名的团队。在农业物种生物信息学方面已经取得了全国性的突出成就（例如，见www.agbase.msstate.edu），该COBRE将用于利用这一成功，并将其应用于与人类健康直接相关的研究。本COBRE中包含的主题代表了广泛的重要人类病原体（肺炎链球菌、流感病毒、志贺氏菌属、单核细胞增生李斯特菌和金黄色葡萄球菌）。我们希望在这次COBRE中结合还原论和全球方法，在这些病原体的研究中取得重大进展。

DESCRIPTION (provided by applicant): A Center of Biomedical Research Excellence (COBRE) in Pathogen-Host Interactions at Mississippi State University is proposed here. This Center's most innovative component is that all of the junior investigator projects feature hypothesis driven studies to determine molecular mechanisms of pathogen-host interactions using, but all projects also include a systems biology component that will move each of the specific fields under investigation forward in a greater than incremental manner. This COBRE will establish infrastructure such as priority access to an existing Core facility (Omics Biology Lab) and a new virtual core that unifies the most commonly used major equipment in an easily accessible unit. All external and internal mentors reviewed the Junior Investigator projects. The External and Internal Advisory Committee members reviewed and critiqued the overall plan and the administrative core. All of the participants in this COBRE have published at least one paper or have already established a collaboration with another COBRE member, demonstrating that this is a natural team and not a team contrived only for this application. The leadership team and advisory committees for this COBRE have developed a plan for mentoring and accountability that will maximize the probability that the junior investigators will graduate to independent status. The External Advisory Committee includes the P.I. of a nearby COBRE that has graduated 8 R01-funded investigators. The goal of this COBRE is to produce teams that will successfully compete for extramural funding over an extended period of time and will be nationally prominent in their field of investigation. National prominence has already been achieved here in bioinformatics of agricultural species (see, for example, www.agbase.msstate.edu), and this COBRE will be used to leverage this success and apply it to research that is directly related to human health. The topics included in this COBRE represent a wide range of important human pathogens {Streptococcus pneumoniae, influenza virus, Shigella species, Listeria monocytogenes, and Staphylococcus aureus). We expect the combined reductionist and global approach in this COBRE to produce significant progress in research on these pathogens.