权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Molecular Control of Long-Range Fronto-Posterior Cortical Projection Maturation Mediating Attention

长程前后皮质投射成熟介导注意力的分子控制

基本信息

批准号：
9258246
负责人：
Elisa Nabel
金额：
$ 4.34万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9258246
关键词：
Address Adolescence Adolescent Adult Affect Anterior Area Attention Attention deficit hyperactivity disorder Autistic Disorder Biological Assay Biological Neural Networks Cells Child Child Psychiatry Clinical Complex Development Diagnosis Discrimination Disease Distal Etiology Event Fellowship Foundations Functional disorder Future Goals Intervention Knowledge Light Macaca Maps Mediating Membrane Membrane Proteins MicroRNAs Molecular Monitor Mus Neurodevelopmental Disorder Neurons Nicotinic Receptors Physiology Process Public Health Rabies Reaction Time Reporting Schizophrenia Secondary to Signal Transduction Snake Venoms Synapses System Testing Therapeutic Training Translations United States Viral Visual Visual Cortex Visual attention Work alpha Bungarotoxin base career cingulate cortex cognitive process designer receptors exclusively activated by designer drugs disability emerging adult expectation extracellular frontal lobe genetic manipulation inhibitor/antagonist insight interdisciplinary approach knock-down neural circuit neurobiological mechanism neurodevelopment neuropsychiatric disorder novel presynaptic prevent symptom cluster symptom management targeted treatment tool touchscreen

项目摘要

Project Summary Neuropsychiatric disorders with developmental origins affect more than 15% of children in the United States and poses a major public health concern requiring $35 billion a year to address in large part due to secondary disability. Clinical efforts to diagnose, treat, and monitor disease have been hindered because they rely on observations of non-specific clusters of symptoms, thus limiting current pharmacologic therapeutics to symptom management. Initial studies report that distal cortical areas fail to connect in these disorders, however, the development of more effective pharmacological interventions requires a better basic understanding of normal maturation and implicated pathophysiology. These processes can be examined in mice. Such work in our lab has identified a necessary driver of maturation—Lynx1— for a projection commonly impaired from the frontal cortex to the visual cortex that mediates visual attention processing. This proposal seeks to more fully examine how Lynx1 promotes normal neural development in this key cortical connection and will investigate the functional and structural consequences of aberrant development in the absence of this important molecule. I hypothesize that Lynx1, an endogenous nicotinic receptor inhibitor, regulates the integration of this projection into forming neural networks that enact visual attention. This pathophysiological insight will promote the development of more effective diagnosis and targeted therapies for neurodevelopmental disorders.

项目总结