SCH: Flexible Electronics For Assessment fo Planning By Children Born Prematurely

SCH：用于评估早产儿计划的灵活电子设备

• 批准号: 9274413
• 负责人: EUGENE C GOLDFIELD
• 金额: $ 54.89万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-26 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274413
• 关键词: Age; Age-Months; Architecture; Assessment tool; Behavior Therapy; Caring; Cerebrum; Child; Cognitive; Development; Developmental Delay Disorders; Devices; Diagnostic; Early identification; Effectiveness; Elastomers; Finger joint structure; Fingers; Foundations; Growth; Hand; Hand functions; Instruction; Joints; Laboratories; Lifting; Liquid substance; Measurement; Measures; Medical; Morbidity - disease rate; Motion; Motor; Nature; Neuronal Plasticity; Outcome; Play; Premature Birth; Premature Infant; Research; Research Design; Safety; Stretching; Surface; Survival Rate; Survivors; Technology; Testing; Therapeutic Intervention; Toddler; Torque; Very Low Birth Weight Infant; Wireless Technology; Work; Wrist; Wrist joint; arm; base; design; flexibility; flexible electronics; improved; innovation; innovative technologies; novel diagnostics; sensor; social; targeted treatment; technological innovation; time orientation; tool

Advances in medical care have improved rates of survival of very low birth weight (VLBW) premature infants (<1.5kg). However, increased survival rates have been accompanied by a significant increase in the number of survivors with reduced cerebral growth and long-term neurodevelopmental motor, cognitive, and social morbidities. There is a critical need for a means of precise identification of the functional nature of these morbidities, to guide the earliest possible behavioral interventions that leverage neural plasticity. A candidate morbidity is force modulation and planning in the use of the hands. This project uses innovative flexible electronic sensor technology embedded in soft materials worn on the hands along with motion capture to examine how children plan and modulate forces during block construction, tool use, and social play. Longitudinal measurement of group differences in force modulation and planning between toddlers born prematurely and typically developing children will make it possible to determine the safety and effectiveness of this innovative sensor technology for early assessment of morbidities due to premature birth. The research leverages work at Harvard on the use of liquid circuits fabricated in soft materials (elastomers) that bend and stretch as they conform to the hands. The outcome will be a new type of device comfortably worn on the hands of toddlers, called "flexi-mitts". Design and fabrication of flexi-mitts present several technical challenges, including (a) embedding the circuitry in multiple layers of material, (b) circuit architectures precisely scaled and spatially arranged to provide measurements of joint angles of the fingers as well as bending torques, (c) simultaneous measurement of finger and wrist joint angles, (d) incorporation of wireless, battery-powered technologies, and (e) circuit architectures that are simplified to fit the form factor of the tiny hands of toddlers. This new flexi-mitt technology has the potential to provide a new diagnostic tool for precise, non-invasive measurement of the effects of premature birth on force modulation and planning. RELEVANCE (See instructions): There is a critical need for diagnostic tools that identify more precisely the nature of developmental delays in prematurely born children. Our project develops flexible electronic sensors embedded in soft materials, called "flexi-mitts", worn on the hands of toddlers to measure planning during play at ages 18, 24, and 30 months. The results will provide the foundation for a new assessment tool.

医疗保健的进步提高了极低出生体重(VLBW)早产儿的存活率 (&lt；1.5公斤)然而，随着存活率的提高，死亡人数也显著增加。 患有脑发育减退和长期神经发育运动、认知和社交功能障碍的幸存者 病态。迫切需要一种手段来精确地识别这些设备的功能性质 病态，以指导利用神经可塑性的最早可能的行为干预。一个 应试者发病是力量调制和谋划在手中的使用。这个项目使用了创新的 灵活的电子传感器技术，嵌入柔软的材料中，戴在手部随着运动而佩戴 了解儿童在积木、工具使用和社交过程中如何计划和调节力量 玩。幼儿力量调节和计划能力群体差异的纵向测量 早产和典型的发育不良儿童将有可能确定其安全性和 这项创新的传感器技术在早期评估早产儿发病率方面的有效性 出生。这项研究利用了哈佛大学在使用软材料制造的液体电路方面的工作 (弹性体)当它们与手相一致时弯曲和伸展。结果将是一种新型的设备 舒适地戴在蹒跚学步的孩子手中，称为“弹性手套”。弹性手套的设计与制作 几个技术挑战，包括(A)在多层材料中嵌入电路，(B)电路 精确缩放和空间排列的建筑，以提供手指关节角度的测量 以及弯曲扭矩，(C)同时测量手指和腕关节角度，(D)合并 无线、电池供电的技术，以及(E)简化以适应外形的电路架构 幼儿的小手的因素。这项新的柔性手套技术有可能提供一种新的 用于精确、非侵入性测量早产对力量调节的影响的诊断工具 和计划。 相关性(请参阅说明)： 迫切需要诊断工具，以更准确地识别发育迟缓的性质 早产的孩子。我们的项目开发了嵌入软材料的柔性电子传感器， 被称为“弹性手套”，戴在18岁、24岁和30岁幼儿的手上，用来衡量他们在玩耍时的计划。 月份。研究结果将为新的评估工具奠定基础。