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Active Bottle for Home Care of Dysphagic Infants - Phase II

用于吞咽困难婴儿家庭护理的主动奶瓶 - 第二阶段

基本信息

批准号：
7683227
负责人：
EUGENE C GOLDFIELD
金额：
$ 74.63万
依托单位：
INFOSCITEX CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-06-01 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7683227
关键词：
Blood Boston Bottle feeding Brain Injuries Breast Breathing Caring Cessation of life Clinical Clinical Research Clinical Trials Collaborations Computer software Computers Decision Making Deglutition Deglutition Disorders Development Devices Diagnosis Dysphasia Engineering Ensure Evolution Exhibits Failure Family Feeding behaviors Gestational Age Home environment Hospitals Infant Infant formula Israel Life Liquid substance Lung Medical center Milk Motor Activity Neurologic Neurologic Examination Nurses Oral Pediatric Hospitals Phase Physicians Pneumonia Premature Infant Process Progress Reports Property Protocols documentation Research Respiration Risk Safety Signal Transduction Site Small Business Innovation Research Grant System Technology Testing Thick Time Update Weight Gain base care systems congenital heart disorder cost design ergonomics experience feeding high risk improved patient home care programs prototype public health relevance respiratory sensor sucking

项目摘要

DESCRIPTION (provided by applicant): Prematurely born infants and term infants with congenital heart disease often develop neurogenic dysphagia, a life-threatening condition characterized by difficulty in coordinating swallowing and breathing during breast and bottle feeding, resulting in a failure to gain weight and increased risk of pneumonia or death, due to taking fluid into the lungs. During Phase I, Infoscitex successfully designed and built a prototype of a computer-controlled bottle feeding system for dispensing either thin-consistency or nectar-thick fluids to dysphagic infants on the basis of sucking and respiration sensor signals. Phase II makes several major advances in the design and capabilities of the active bottle that have resulted from the Phase I bench tests and Dr. Goldfield's ongoing research into swallowing by premature infants. The Active Bottle for infants with neurogenic dysphagia is evaluated during Phase II by means of a clinical trial consisting of tests involving dispensing of thin or thick fluids. At the same time, the Active Bottle is advanced towards a commercial home-care product. Close collaboration between the engineering team at Infoscitex and the clinical teams at both Children's Hospital Boston and Beth Israel Deaconess Medical Center throughout the project, will ensure that clinical trials with the Active Bottle are successful. Positive clinical results, along with the evolution of the Active Bottle towards a more ergonomic, less expensive, home care system will allow infants with feeding problems caused by neurogenic dysphasia a safer and more effective means for feeding, while reducing development of aspiration-induced pneumonia, and hastening NICU discharge of infants with neurogenic dysphagia, reducing NICU cost and allowing infants to come home to their families sooner. PUBLIC HEALTH RELEVANCE Premature infants born less than 33 weeks gestational age, or born at term with congenital heart disease, have a higher risk of brain injury than healthy term infants. These two groups of infants are also more likely to experience swallowing and other coordination problems during bottle feedings. Swallowing disorder due to neurological abnormality is called neurogenic dysphagia. During care in the NICU, and eventually during the long term home care after hospital discharge, infants with neurogenic dysphagia may require a feeding protocol that manipulates the properties of the fluids being fed to them. This research is aimed at the development of a computer-controlled milk delivery system that would 1) encourage and maintain proper oral feeding behavior in infants with neurogenic dysphagia, 2) reduce development of aspiration-induced pneumonia, 3) hasten NICU discharge of infants with neurogenic dysphagia, reducing NICU cost, and allowing infants to come home to their families sooner.

描述（由申请人提供）：患有先天性心脏病的早产婴儿和足月婴儿通常会出现神经性吞咽困难，这是一种危及生命的疾病，其特征是在母乳喂养和奶瓶喂养期间难以协调吞咽和呼吸，导致体重无法增加，并且由于将液体吸入肺部而增加肺炎或死亡的风险。