Radiofrequency Tumor Ablation at Low Frequencies

低频射频肿瘤消融

• 批准号: 7512390
• 负责人: Dieter Haemmerich
• 金额: $ 16.59万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7512390
• 关键词: Ablation; Adrenal Glands; Agitation; Bos taurus; Cattle; Coagulation Process; Coagulative necrosis; Computer Simulation; Data; Devices; Disseminated Malignant Neoplasm; Electric Conductivity; Electrodes; Electrosurgery; Frequencies; Heating; Human; Image; Invasive; Kidney; Liver; Liver neoplasms; Lung; Malignant Neoplasms; Malignant neoplasm of liver; Measurement; Measures; Methods; Modeling; Morbidity - disease rate; Necrosis; Normal tissue morphology; Operative Surgical Procedures; Patients; Property; Prostate; Public Health; Radiofrequency Interstitial Ablation; Range; Rattus; Recovery; Recurrence; Simulate; Site; Standards of Weights and Measures; System; Temperature; Testing; Time; Tissues; Tumor Tissue; base; bone; cancer site; cancer therapy; design; human data; human tissue; in vivo; killings; radiofrequency; tumor

DESCRIPTION (provided by applicant) Radiofrequency (RF) ablation is a promising, minimally invasive heat-based method used to ablate cancer of the liver, kidney, bone, and lung. Under imaging guidance, an electrode is inserted into the tumor, and radiofrequency current is applied to the electrode resulting in ionic agitation and tissue heating. The tumor is destroyed by coagulative necrosis once it reaches temperatures above 50 degrees C. One of the major advantages of RF ablation is that it can be applied in a minimally invasive fashion, resulting in rapid patient recovery and low morbidity. Due to historic reasons, commercial RF ablation devices operate in the frequency range of 450 - 500 kHz. We have previously shown in computational models that RF ablation in a lower frequency range (~10 kHz) may preferentially heat tumor tissue. In this proposal we will validate this hypothesis of preferential heating of cancer at lower frequencies. We will measure data on electrical tissue properties of human tumor tissue, use these data to compare RF ablation at standard at low frequencies in computer models, and finally confirm benefits of low-frequency RF ablation in ex vivo studies. PUBLIC HEALTH RELEVANCE Successful completion of this project may result in a more effective treatment of cancer that will provide preferential heating and kill of cancer and sparing of normal tissue.

描述(申请人提供)射频消融术是一种很有前途的微创热疗方法，用于消融肝、肾、骨和肺癌。在成像引导下，将电极插入肿瘤，并向电极施加射频电流，导致离子搅动和组织加热。一旦达到50摄氏度以上的温度，肿瘤就会被凝固性坏死摧毁。射频消融的主要优势之一是它可以以微创的方式应用，导致患者快速恢复和低发病率。由于历史原因，商用射频消融设备工作在450-500 kHz的频率范围内。我们之前已经在计算模型中表明，在较低频率范围(~10 kHz)的射频消融可能优先加热肿瘤组织。在这项提议中，我们将验证这一假设，即癌症在较低频率下优先加热。我们将测量人体肿瘤组织的电组织特性数据，使用这些数据在计算机模型中比较标准低频射频消融，最后在体外研究中确认低频射频消融的好处。与公共卫生相关该项目的成功完成可能会导致更有效的癌症治疗，这将为癌症提供优先的加热和杀灭，并保留正常组织。