Radiofrequency Tumor Ablation at Low Frequencies

低频射频肿瘤消融

• 批准号: 7512390
• 负责人: Dieter Haemmerich
• 金额: $ 16.59万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7512390
• 关键词: Ablation; Adrenal Glands; Agitation; Bos taurus; Cattle; Coagulation Process; Coagulative necrosis; Computer Simulation; Data; Devices; Disseminated Malignant Neoplasm; Electric Conductivity; Electrodes; Electrosurgery; Frequencies; Heating; Human; Image; Invasive; Kidney; Liver; Liver neoplasms; Lung; Malignant Neoplasms; Malignant neoplasm of liver; Measurement; Measures; Methods; Modeling; Morbidity - disease rate; Necrosis; Normal tissue morphology; Operative Surgical Procedures; Patients; Property; Prostate; Public Health; Radiofrequency Interstitial Ablation; Range; Rattus; Recovery; Recurrence; Simulate; Site; Standards of Weights and Measures; System; Temperature; Testing; Time; Tissues; Tumor Tissue; base; bone; cancer site; cancer therapy; design; human data; human tissue; in vivo; killings; radiofrequency; tumor

DESCRIPTION (provided by applicant) Radiofrequency (RF) ablation is a promising, minimally invasive heat-based method used to ablate cancer of the liver, kidney, bone, and lung. Under imaging guidance, an electrode is inserted into the tumor, and radiofrequency current is applied to the electrode resulting in ionic agitation and tissue heating. The tumor is destroyed by coagulative necrosis once it reaches temperatures above 50 degrees C. One of the major advantages of RF ablation is that it can be applied in a minimally invasive fashion, resulting in rapid patient recovery and low morbidity. Due to historic reasons, commercial RF ablation devices operate in the frequency range of 450 - 500 kHz. We have previously shown in computational models that RF ablation in a lower frequency range (~10 kHz) may preferentially heat tumor tissue. In this proposal we will validate this hypothesis of preferential heating of cancer at lower frequencies. We will measure data on electrical tissue properties of human tumor tissue, use these data to compare RF ablation at standard at low frequencies in computer models, and finally confirm benefits of low-frequency RF ablation in ex vivo studies. PUBLIC HEALTH RELEVANCE Successful completion of this project may result in a more effective treatment of cancer that will provide preferential heating and kill of cancer and sparing of normal tissue.

描述（由申请人提供）射频（RF）消融是一种有希望的，微创的基于热热的方法，用于消融肝脏，肾脏，骨骼和肺癌。在成像引导下，将电极插入肿瘤中，并将射频电流应用于电极，从而导致离子搅拌和组织加热。一旦达到50度的温度，肿瘤就会被凝结坏死破坏。RF消融的主要优势之一是可以以微创的方式应用，从而导致患者迅速恢复和发病率低。由于历史原因，商业RF消融设备的频率范围为450-500 kHz。我们以前在计算模型中显示了RF消融在较低的频率范围（〜10 kHz）可能会优先加热肿瘤组织。在此提案中，我们将验证以较低频率对癌症优先加热的假设。我们将测量有关人类肿瘤组织的电组织特性的数据，使用这些数据比较计算机模型中低频以低频的标准消融，并最终确认在体内研究中低频RF消融的益处。公共卫生相关性成功完成该项目可能会导致对癌症的更有效治疗，从而提供优先加热和杀死癌症并保留正常组织。