Radiofrequency Tumor Ablation at Low Frequencies

低频射频肿瘤消融

• 批准号: 7665562
• 负责人: Dieter Haemmerich
• 金额: $ 16.59万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7665562
• 关键词: Ablation; Adrenal Glands; Agitation; Cattle; Coagulation Process; Coagulative necrosis; Computer Simulation; Data; Devices; Disseminated Malignant Neoplasm; Electric Conductivity; Electrodes; Electrosurgery; Frequencies; Heating; Human; Image; Kidney; Liver; Liver neoplasms; Lung; Malignant Neoplasms; Malignant neoplasm of liver; Measurement; Measures; Methods; Modeling; Morbidity - disease rate; Necrosis; Normal tissue morphology; Operative Surgical Procedures; Patients; Property; Prostate; Radiofrequency Interstitial Ablation; Rattus; Recovery; Recurrence; Simulate; Site; System; Temperature; Testing; Time; Tissues; Tumor Tissue; base; bone; cancer site; design; effective therapy; human data; human tissue; in vivo; killings; minimally invasive; public health relevance; radiofrequency; tumor

DESCRIPTION (provided by applicant) Radiofrequency (RF) ablation is a promising, minimally invasive heat-based method used to ablate cancer of the liver, kidney, bone, and lung. Under imaging guidance, an electrode is inserted into the tumor, and radiofrequency current is applied to the electrode resulting in ionic agitation and tissue heating. The tumor is destroyed by coagulative necrosis once it reaches temperatures above 50 degrees C. One of the major advantages of RF ablation is that it can be applied in a minimally invasive fashion, resulting in rapid patient recovery and low morbidity. Due to historic reasons, commercial RF ablation devices operate in the frequency range of 450 - 500 kHz. We have previously shown in computational models that RF ablation in a lower frequency range (~10 kHz) may preferentially heat tumor tissue. In this proposal we will validate this hypothesis of preferential heating of cancer at lower frequencies. We will measure data on electrical tissue properties of human tumor tissue, use these data to compare RF ablation at standard at low frequencies in computer models, and finally confirm benefits of low-frequency RF ablation in ex vivo studies. PUBLIC HEALTH RELEVANCE Successful completion of this project may result in a more effective treatment of cancer that will provide preferential heating and kill of cancer and sparing of normal tissue.

描述（由申请人提供） 射频（RF）消融是一种有前途的微创热基方法，用于消融肝癌、肾癌、骨癌和肺癌。在成像引导下，将电极插入肿瘤中，并向电极施加射频电流，导致离子搅动和组织加热。一旦温度达到 50 摄氏度以上，肿瘤就会被凝固性坏死所破坏。射频消融的主要优点之一是它可以以微创方式应用，从而使患者恢复快且发病率低。由于历史原因，商业射频消融设备的工作频率范围为 450 - 500 kHz。我们之前在计算模型中表明，较低频率范围（~10 kHz）的射频消融可能会优先加热肿瘤组织。在本提案中，我们将验证以较低频率优先加热癌症的假设。我们将测量人体肿瘤组织的电组织特性数据，利用这些数据在计算机模型中比较低频射频消融的标准，并最终在离体研究中确认低频射频消融的益处。公共健康相关性 该项目的成功完成可能会带来更有效的癌症治疗方法，从而优先加热并杀死癌症并保留正常组织。