ENANTIOSELECTIVE TRIPLET SENSITIZATION REACTIONS

项目总结/摘要 光化学反应是一套不发达的生物医学技术， research.这些反应对于发现新的药物和生物探针具有重要的价值 因为光的吸收导致高能电子激发中间体的形成 它可以产生应变和不寻常的分子结构，这些分子结构无法以其他方式合成。 然而，控制这些高能量所产生的产品的精确三维形状， 中间体是一个长期存在的挑战，没有通用的解决方案。 这个建议是基于发现一个以前未知的效果，即刘易斯酸配位 施加在有机分子的激发态上。我们将研究如何利用这种影响， 控制使用光化学反应产生的化合物的三维形状。特别是， 本研究的三个具体目标都集中在探索这种效应的普遍性上。 目标1.我们正在探索使用此策略可访问的产品的通用性。 目标2.我们正在探索可以使用这种策略激活的有机底物的一般性。 目标3.我们正在探索催化三重态敏化对各种其他催化三重态敏化平台的一般性。 activation. 这些方法解决了有机合成中一个重要的百年问题。因此，我们预计， 我们的研究成果将对基础学术化学研究和 生物医学科学家合成和发现下一代救命药物的能力。

PROJECT SUMMARY/ABSTRACT Photochemical reactions constitute an underdeveloped set of enabling technologies for biomedical research. These reactions would be of great value to the discovery of new drugs and biological probes because the absorption of light results in the formation of high-energy, electronically excited intermediates that can produce strained and unusual molecular architectures that can be synthesized in no other way. However, control over the precise three-dimensional shapes of the products arising from these high-energy intermediates has been a long-standing challenge with no general solutions. This Proposal is based upon the discovery of a previously unknown effect that Lewis acid coordination exerts upon the excited states of organic molecules. We will study how this effect can be exploited to control the three-dimensional shape of compounds produced using photochemical reactions. In particular, the three Specific Aims of this research center on an exploration of the generality of this effect. Aim 1. We are exploring the generality of products that are accessible using this strategy. Aim 2. We are exploring the generality of organic substrates that can be activated using this strategy. Aim 3. We are exploring the generality of catalytic triplet sensitization to various other platforms for catalytic activation. These methods address an important, century-old problem in organic synthesis. Thus, we expect that the results of our research will have significant impacts both in fundamental academic chemical research and on the ability of biomedical scientists to synthesize and discover the next generation of life-saving drugs.