SYNTHETIC PHOTOCHEMISTRY

合成光化学

• 批准号: 10798418
• 负责人: TEHSHIK P YOON
• 金额: $ 5.14万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10798418
• 关键词: Biological; Biomedical Research; Chemical Structure; Chemicals; Complex; Development; Electronics; Equipment; Generations; Goals; Grant; Investigation; Life; Light; Medicine; Metals; Methods; Modernization; Molecular Medicine; Outcome; Pharmaceutical Preparations; Phase; Photochemistry; Photons; Process; Reaction; Request for Proposals; Research; Stimulus; Structure; System; base; catalyst; design; interest; novel; novel strategies; small molecule therapeutics; stereochemistry; tool

PROJECT SUMMARY/ABSTRACT Synthetic photochemistry is a powerful tool for biomedical research. The small-molecule therapeutics that constitute the core of modern molecular medicine occupy a relatively narrow segment of chemical diversity space. Photochemistry offers a new capability that can expand the range of chemical structures that can be investigated for their biological activity and their potential as new life-saving drugs. Specifically, reactions that are driven by light can use the energy of a photon to produce highly reactive intermediates that react in ways that are not accessible by other means. Our group's research focuses on the discovery of reaction methods that can control the outcomes of photochemical processes in predictable ways. We have a long-standing interest in the development of mechanistically novel catalytic processes that are directly applicable to the synthesis of complex bioactive compounds. We are also interested in the use of external stimuli that can control or divert the intrinsic reactivity of open-shelled photogenerated intermediates towards desirable synthetic goals. Finally, we are deeply committed to elucidating the mechanisms by which photochemical transformations occur. The next phase of our research will continue to investigate these broad themes. We propose investigations into new strategies for controlling the stereochemistry of diverse photochemical reactions. We will study a new approach towards the generation of carbocationic intermediates from photoredox activation. Finally, we will develop a new class of photoreactions that take advantage of the direct photochemistry of base metal coordination complexes. These studies will result in new, generalizable strategies for the controlled photochemical synthesis of complex organic molecules.

项目总结/文摘

项目成果

Cu(II) salts as terminal oxidants in visible-light photochemical oxidation reactions.

Cu(II) 盐作为可见光光化学氧化反应中的末端氧化剂。

• DOI: 10.1039/d3ob01678a
• 发表时间: 2023
• 期刊: Organic & biomolecular chemistry
• 影响因子: 3.2
• 作者: Lutovsky,GraceA;Yoon,TehshikP
• 通讯作者: Yoon,TehshikP

A General Strategy for the Synthesis of Truxinate Natural Products Enabled by Enantioselective [2+2] Photocycloadditions.

通过对映选择性 [2 2] 光环加成合成 Truxate 天然产物的一般策略。

• DOI: 10.1021/jacs.3c07132
• 发表时间: 2023
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Genzink,MatthewJ;Rossler,MatthewD;Recendiz,Herman;Yoon,TehshikP
• 通讯作者: Yoon,TehshikP

Selective Cross-Ketonization of Carboxylic Acids Enabled by Metallaphotoredox Catalysis.

• DOI: 10.1002/anie.202213739
• 发表时间: 2022-12-23
• 期刊: Angewandte Chemie (International ed. in English)

Investigating the Effect of Lewis Acid Co-catalysts on Photosensitized Visible-Light De Mayo Reactions.

• DOI: 10.1021/acs.orglett.3c01321
• 发表时间: 2023-05
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Riley M Kelch;A. Whyte;Eunji Lee;T. Yoon

Allylic Amination of Highly Substituted Alkenes Enabled by Photoredox Catalysis and Cu(II)-Mediated Radical-Polar Crossover.

通过光氧化还原催化和 Cu(II) 介导的自由基-极性交叉实现高度取代烯烃的烯丙基胺化。

• DOI: 10.1021/acs.orglett.3c01774
• 发表时间: 2023
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Lutovsky,GraceA;Plachinski,EllieF;Reed,NicholasL;Yoon,TehshikP
• 通讯作者: Yoon,TehshikP