SYNTHETIC PHOTOCHEMISTRY

项目总结/摘要 合成光化学是生物医学研究的有力工具。小分子疗法， 构成现代分子医学核心的化学多样性占有相对狭窄的一段 空间光化学提供了一种新的能力，可以扩大化学结构的范围， 研究其生物活性及其作为新的救生药物的潜力。具体来说，反应 它们可以利用光子的能量产生高度活性的中间体， 无法通过其他方式访问的方式。 我们小组的研究重点是发现反应方法，可以控制的结果， 以可预测的方式进行光化学过程。我们长期以来一直关注 直接适用于合成复杂的生物活性物质的机械新颖的催化方法， 化合物.我们也对使用外部刺激感兴趣，这些刺激可以控制或转移内在的 开壳光生中间体对所需合成目标的反应性。最后，我们 致力于阐明光化学转化发生的机制。 我们的下一阶段研究将继续探讨这些广泛的主题。我们建议调查 控制不同光化学反应的立体化学的新策略。我们将研究 从光氧化还原活化产生碳阳离子中间体的新方法。最后我们 将开发一类新的光反应，利用直接光化学的基础金属 配合物 这些研究将导致新的，可推广的战略控制光化学合成的 复杂的有机分子

PROJECT SUMMARY/ABSTRACT Synthetic photochemistry is a powerful tool for biomedical research. The small-molecule therapeutics that constitute the core of modern molecular medicine occupy a relatively narrow segment of chemical diversity space. Photochemistry offers a new capability that can expand the range of chemical structures that can be investigated for their biological activity and their potential as new life-saving drugs. Specifically, reactions that are driven by light can use the energy of a photon to produce highly reactive intermediates that react in ways that are not accessible by other means. Our group's research focuses on the discovery of reaction methods that can control the outcomes of photochemical processes in predictable ways. We have a long-standing interest in the development of mechanistically novel catalytic processes that are directly applicable to the synthesis of complex bioactive compounds. We are also interested in the use of external stimuli that can control or divert the intrinsic reactivity of open-shelled photogenerated intermediates towards desirable synthetic goals. Finally, we are deeply committed to elucidating the mechanisms by which photochemical transformations occur. The next phase of our research will continue to investigate these broad themes. We propose investigations into new strategies for controlling the stereochemistry of diverse photochemical reactions. We will study a new approach towards the generation of carbocationic intermediates from photoredox activation. Finally, we will develop a new class of photoreactions that take advantage of the direct photochemistry of base metal coordination complexes. These studies will result in new, generalizable strategies for the controlled photochemical synthesis of complex organic molecules.