Mentoring in Addiction Treatment Research

项目摘要 此K24竞争续订申请的主要目标是使Eden Evins，M.D.，M.P.H.达到1) 开展职业发展活动，加强和推广以病人为中心的成瘾研究(POAR)； 2)为POAR的早期研究人员提供密集和高质量的指导。K24续订将 让埃文斯医生有时间致力于职业发展，以增加她的临床成瘾的影响 以及对初级临床研究人员的密集指导，否则这些研究将花费在临床和 行政职责。埃文斯博士，哈佛医学院精神病学副教授兼主任 麻省理工学院成瘾医学综合中心自1999年以来一直进行POAR，强调研究 整合不同的治疗方法，接近难以治疗的人群并影响临床实践。 埃文斯博士已经完成了她最初颁发的K24奖项的主要目标。她已经指导了超过35名少年 研究人员，其中许多人获得了K奖，已经撰写了100份出版物，其中包括42份出版物，其中一名学员为 第一作者。她进行了一系列研究，改变了吸烟的临床实践指南。 对于患有严重精神疾病的人，请停止使用。 埃文斯博士的续签申请研究计划包括在NIDA资助的继续担任PI的工作 治疗研究，担任研究的联合调查员，受试者为PI。此外，她计划提交 建议1)将严重精神病患者的戒烟治疗范围扩大到 社区，以及2)研究大麻使用对精神症状、认知表现和 有精神障碍的人和青少年中的上瘾。 埃文斯博士的指导计划包括在1)药物滥用的临床方面对她的学员进行培训；2)设计 和实施药物滥用研究；3)准备科学论文和演讲；4)写作 成功的拨款申请；以及5)负责任的研究工作。她将通过一项 个人和小组会议的结合；协作指导；角色建模；以及整合 MGH临床研究部和职业发展办公室的指导。 埃文斯博士的职业发展计划包括增加她在多式联运和光学方面的专业知识 神经成像、评估在特殊人群中使用大麻的影响；新的数据分析策略；以及 遗传学。这些活动将加强埃文斯博士的研究和她的指导能力。 这一应用对公共卫生的重要性与开发新的和有效的 药物依赖和双重诊断患者的治疗，以及培训下一代 研究人员需要发展他们所需的技能，以便有效地对这些患者群体进行POAR。

Project Summary The primary goals of this K24 competing renewal application are to enable Eden Evins, M.D., M.P.H., to 1) conduct career development activities to enhance and extend her patient-oriented addiction research (POAR); and 2) provide intensive and high-quality mentorship to early-career investigators in POAR. A K24 renewal will to give Dr. Evins protected time to devote to career development to increase the impact of her clinical addiction research and to intensive mentoring of junior clinical researchers that would otherwise be spent on clinical and administrative duties. Dr. Evins, Associate Professor of Psychiatry at Harvard Medical School and Director of the Mass General Center for Addiction Medicine, has conducted POAR since 1999, emphasizing studies that integrate different treatment approaches, approach difficult to treat populations and influence clinical practice. Dr. Evins has accomplished the major goals of her initial K24 award. She has mentored over 35 junior investigators, many with K awards, has authored 100 publications, including 42 publications with a mentee as first author. She has conducted a series of studies that have changed clinical practice guidelines for smoking cessation for those with serious mental illness. Dr. Evins’ research plan for this renewal application includes continued work as a PI in NIDA funded treatment research, to serve as Co-Investigator on studies with mentees as PI. Further, she plans to submit proposals to 1) expand the scope of smoking cessation treatment for those with serious mental illness to the community, and 2) study effects of cannabis use on psychiatric symptoms, cognitive performance and addiction in those with psychiatric disorders and in adolescents. Dr. Evins’ mentoring plan includes training her mentees in 1) clinical aspects of drug abuse; 2) designing and implementing drug abuse research studies; 3) preparing scientific papers and presentations; 4) writing successful grant applications; and 5) responsible conduct of research. She will accomplish this with a combination of individual and group meetings; collaborative mentoring; role modeling; and integrating mentoring with the MGH Division of Clinical Research and the Office of Career Development. Dr. Evins’ career development plan involves increasing her expertise in multimodal and optical neuroimaging, assessment of effects of cannabis use in special populations; novel data analytic strategies; and genetics. These activities will both enhance Dr. Evins’ research and her mentoring capacity. The public health importance of this application is related to the need to develop new and effective treatments for drug dependent and dually diagnosed patients, and the need to train the next generation of investigators to develop the skills they require to effectively conduct POAR with this patient population.