Rechargeable Antimicrobial Textiles to Reduce Occupational Risk of Healthcare Personnel

可充电抗菌纺织品可降低医护人员的职业风险

• 批准号: 9751027
• 负责人: Nancy Goodyear
• 金额: $ 23.29万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9751027
• 关键词: Rechargeable; Antimicrobial; Textiles; Reduce; Occupational

Project Description/Abstract This project addresses the healthcare & social assistance (HCSA) sector and the immune, infectious and dermal disease prevention cross-sector, and addresses the strategic goal to reduce occupational immune, infectious, and dermal disease and intermediate goal to conduct research to reduce worker illness and injury, and to advance worker well-being. Healthcare personnel (HCP) have a high occupational burden of exposure to infectious agents. Service textiles play an important role in the acquisition and transmission of pathogenic microorganisms. Therefore, reduction of pathogens on textile surfaces is an integral component of infection prevention to reduce the burden of exposure and protect HCP. Antimicrobial textiles have the potential to reduce exposure, but current products use quaternary ammonium salts, copper or silver coatings, and their efficacy decreases rapidly because wash/wear can remove the coating. Further, these compounds are known to induce microbial resistance, their antimicrobial functions can be significantly reduced by soils and blood/body fluid, and the actual antimicrobial potency after each wash/use cannot be monitored. We will use N-halamine-based monitorable and rechargeable antimicrobial technology to reduce microbial burden on service textiles. N-halamines are widely used water and food disinfectants with antimicrobial efficacy similar to that of hypochlorite bleach, but they are much more stable and safer to use, with no documented resistant species. We will covalently bind N-halamines onto textiles, and the N-halamines will provide potent antimicrobial functions by killing the microorganisms. Based on our preliminary results, the antimicrobial activity will not be affected by soils/blood, and it can last for months to years with good cytocompatibility. Further, users can periodically check the level of N-halamines on the textiles with potassium iodine (KI) strips, and if the tests show that the covalently bonded chlorine contents are below the recommended level (to be determined in this study), the lost chlorines can be recharged by a bleach rinse during laundering. The recharging can be repeated as needed through the entire service life of the textiles. The specific aims of this project are to: (1) covalently bind N-halamines onto healthcare service textile materials and characterize the physical/mechanical properties of the new materials; (2) evaluate in vitro the antimicrobial performance under simulated in-use conditions, the cytotoxicity of the new materials and the risk of microbial resistance to the materials. The outputs of this project will be publications, reports, conference proceedings, and presentations/posters of the research results, and N-halamine-based antimicrobial fabrics as tools to reduce occupational exposure. The intermediate outcomes will include citations in the literature, inventions of new antimicrobial fabrics, and possible adoption of the new materials in practice, which can lead to the end outcomes of reduction in workplace hazardous exposures, addressing Research to Practice (r2p) by translating the new technologies to the HCSA sector to prevent/reduce HCP exposures to infectious agents and advance worker well-being.

项目描述/摘要 该项目涉及医疗保健和社会援助部门以及免疫、传染和 皮肤病预防跨部门，并解决战略目标，以减少职业免疫， 传染病、皮肤病和中间目标是进行研究以减少工人生病和受伤， 并促进工人福利。医疗保健人员（HCP）有很高的职业暴露负担 传染源服务用纺织品在致病菌的获得和传播中起着重要作用， 微生物的因此，减少纺织品表面上的病原体是感染的一个组成部分 预防以减少暴露负担并保护HCP。抗菌纺织品有潜力 减少暴露，但目前的产品使用季铵盐、铜或银涂层，以及它们的 因为洗涤/磨损可除去涂层，所以功效迅速降低。此外，已知这些化合物 为了诱导微生物的耐药性，它们的抗微生物功能可以被土壤显著降低， 血液/体液中，并且每次洗涤/使用后的实际抗微生物效力不能被监测。 我们将使用基于N-卤胺的可监测和可充电的抗菌技术来减少微生物 服务纺织品的负担。N-卤胺是一种广泛使用的水和食品消毒剂，具有抗菌功效 类似于次氯酸盐漂白剂，但它们更稳定，使用更安全，没有记录 抗性物种我们将N-卤胺共价结合到纺织品上，N-卤胺将提供有效的 通过杀死微生物来发挥抗微生物功能。根据我们的初步结果， 不会受到土壤/血液的影响，并且可以持续数月至数年，具有良好的细胞相容性。此外，本发明还 使用者可定期用碘化钾试纸检查纺织品上的N-卤胺含量， 测试表明，共价键合的氯含量低于推荐水平（将在 这项研究），流失的氯可以在洗涤过程中通过漂白剂漂洗补充。充电可以是 在纺织品的整个使用寿命期间根据需要重复。该项目的具体目标是：（1） 将N-卤胺共价结合到医疗服务纺织材料上，并表征其物理/机械性能 新材料的性能;（2）在模拟使用条件下进行体外抗菌性能评价 新材料的细胞毒性和微生物对材料耐药性的风险。的 该项目的产出将是出版物、报告、会议记录和 研究结果和N-卤胺基抗菌织物作为减少职业接触的工具。的 中期成果将包括文献中的引用，新型抗菌织物的发明， 在实践中可能采用新材料，这可能导致减少 工作场所危险暴露，通过将新技术转化为实践研究（r2 p） 用于HCSA部门，以预防/减少HCP暴露于传染性病原体并促进工人健康。