Rechargeable Antimicrobial Textiles to Reduce Occupational Risk of Healthcare Personnel

项目说明/摘要 该项目涉及医疗保健和社会援助(HCSA)部门以及免疫、传染病和 皮肤病预防跨部门，并解决减少职业免疫的战略目标， 传染病、皮肤病和中期目标是进行研究，以减少工人的疾病和伤害， 并增进工人的福祉。医护人员(HCP)的职业暴露负担很高 对感染性病原体。服务用纺织品在致病原的获取和传播中发挥重要作用 微生物。因此，减少纺织品表面的病原体是感染的一个组成部分。 预防，以减少接触负担和保护HCP。抗菌纺织品有可能 减少暴露，但目前的产品使用季铵盐、铜或银涂层，以及它们的 药效迅速下降，因为清洗/磨损会去除涂层。此外，这些化合物是已知的 为了诱导微生物抗药性，它们的抗菌功能可以显著地被土壤和 血液/体液，以及每次洗涤/使用后的实际抗菌效力无法监测。 我们将使用基于N-卤胺的可监测和可充电的抗菌技术来减少微生物 服务纺织品的负担。N-卤胺是广泛使用的具有抗菌效果的水和食品消毒剂。 与次氯酸盐漂白剂相似，但使用起来更稳定、更安全，没有任何文件记录 抵抗力强的物种。我们将N-卤胺共价结合到纺织品上，N-卤胺将提供有效的 通过杀死微生物来发挥抗微生物的作用。根据我们的初步结果，抗菌活性 不受土壤/血液的影响，可持续数月至数年，具有良好的细胞相容性。此外， 用户可以定期检查带有碘化钾(KI)条的纺织品上的N-卤胺水平，如果 测试表明，共价键合的氯含量低于建议的水平(将在 这项研究)，丢失的氯可以在洗涤过程中通过漂白剂漂洗来补充。充值可以是 在纺织品的整个使用寿命内根据需要重复使用。本项目的具体目标是：(1) 将N-卤胺共价结合到医疗服务用纺织品材料上，并表征其物理/机械性能 新材料的性能；(2)模拟使用条件下的体外抗菌性能评价 新材料的细胞毒性和微生物对材料产生耐药性的风险。这个 该项目的产出将是出版物、报告、会议记录和专题介绍/海报 研究结果，以及以N-卤胺为基础的抗菌织物作为减少职业暴露的工具。这个 中间成果将包括文献中的引用，新抗菌织物的发明，以及 在实践中可能采用新材料，这可能导致减少 工作场所危险暴露，通过翻译新技术解决从研究到实践(R2P) 向HCSA部门提供技术援助，以预防/减少HCP对感染性病原体的暴露，提高工人的福利。

Project Description/Abstract This project addresses the healthcare & social assistance (HCSA) sector and the immune, infectious and dermal disease prevention cross-sector, and addresses the strategic goal to reduce occupational immune, infectious, and dermal disease and intermediate goal to conduct research to reduce worker illness and injury, and to advance worker well-being. Healthcare personnel (HCP) have a high occupational burden of exposure to infectious agents. Service textiles play an important role in the acquisition and transmission of pathogenic microorganisms. Therefore, reduction of pathogens on textile surfaces is an integral component of infection prevention to reduce the burden of exposure and protect HCP. Antimicrobial textiles have the potential to reduce exposure, but current products use quaternary ammonium salts, copper or silver coatings, and their efficacy decreases rapidly because wash/wear can remove the coating. Further, these compounds are known to induce microbial resistance, their antimicrobial functions can be significantly reduced by soils and blood/body fluid, and the actual antimicrobial potency after each wash/use cannot be monitored. We will use N-halamine-based monitorable and rechargeable antimicrobial technology to reduce microbial burden on service textiles. N-halamines are widely used water and food disinfectants with antimicrobial efficacy similar to that of hypochlorite bleach, but they are much more stable and safer to use, with no documented resistant species. We will covalently bind N-halamines onto textiles, and the N-halamines will provide potent antimicrobial functions by killing the microorganisms. Based on our preliminary results, the antimicrobial activity will not be affected by soils/blood, and it can last for months to years with good cytocompatibility. Further, users can periodically check the level of N-halamines on the textiles with potassium iodine (KI) strips, and if the tests show that the covalently bonded chlorine contents are below the recommended level (to be determined in this study), the lost chlorines can be recharged by a bleach rinse during laundering. The recharging can be repeated as needed through the entire service life of the textiles. The specific aims of this project are to: (1) covalently bind N-halamines onto healthcare service textile materials and characterize the physical/mechanical properties of the new materials; (2) evaluate in vitro the antimicrobial performance under simulated in-use conditions, the cytotoxicity of the new materials and the risk of microbial resistance to the materials. The outputs of this project will be publications, reports, conference proceedings, and presentations/posters of the research results, and N-halamine-based antimicrobial fabrics as tools to reduce occupational exposure. The intermediate outcomes will include citations in the literature, inventions of new antimicrobial fabrics, and possible adoption of the new materials in practice, which can lead to the end outcomes of reduction in workplace hazardous exposures, addressing Research to Practice (r2p) by translating the new technologies to the HCSA sector to prevent/reduce HCP exposures to infectious agents and advance worker well-being.