Development of hydraulically fractured oil and natural gas sites and incidence of atrial fibrillation claims in Colorado's All Payer Claims Database

科罗拉多州所有付款人索赔数据库中水力压裂石油和天然气站点的开发以及心房颤动索赔的发生率

• 批准号: 9883051
• 负责人: Lisa Marie McKenzie
• 金额: $ 11.66万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9883051
• 关键词: Address; Air Pollution; Area; Arrhythmia; Atrial Fibrillation; Blood Pressure; Blood Vessels; Cerebrovascular Disorders; Cohort Studies; Colorado; Crossover Design; Data; Databases; Development; Diagnosis; Economically Deprived Population; Elderly; Embolism; Environmental Risk Factor; Epidemiology; Etiology; Fracture; Future; Gases; General Population; Goals; Health; Heart failure; Impairment; Incidence; Information Systems; Interruption; Link; Measures; Methods; Morbidity - disease rate; Natural Gas; Oils; Outcome; Patients; Persons; Population; Prevention; Prospective Studies; Quality of life; Resources; Risk; Series; Site; Testing; Thromboembolism; Thrombosis; Time; Woman; Work; arterial stiffness; clinically significant; course development; design; experience; mortality; noise pollution; prospective; stroke risk

Project Summary/Abstract Atrial fibrillation (AF) is the most common and clinically significant cardiac arrhythmia and results in impaired quality of life and substantially elevated risks for stroke, systemic thromboembolism and heart failure. Our preliminary data indicates that people living near HFOG well sites may experience increases in blood pressure and arterial stiffness that are associated with AF. The development of hydraulically fractured oil and natural gas (HFOG or “fracking”) well sites is associated with two emerging environmental risk factors for AF, air and noise pollution. While this evidence indicates that AF patients who reside in close proximity to the development complications, is if the air and noise pollution that occur during the development of HFOG well sites contribute to the etiology and burden of AF. We lack the preliminary data necessary to justify and efficiently design the prospective study will be necessary to address the pressing need to understand these etiological relationships. Without this preliminary data, we are unable to advance methods to investigate the temporal relationships between environmental risks related to HFOG well sites and AF. Our long-term goal is to understand the epidemiological relationships between environmental risks associated with HFOG and AF related health outcomes. The overall objective for this proposal is to link the Colorado All Payer's Claim Database (APCD) and the Colorado O&G Information system (COGIS) to obtain the preliminary data necessary to justify and inform the design of a comprehensive cohort study. To meet this objective, we will employ a longitudinal interrupted time-series crossover design to retrospectively follow ~ 2500 AF patients in the APCD living within 1.6 kilometers (1-mile) of 830 HFOG well sites developed between 2010 and 2015. Our central hypothesis is that there is an increased risk of AF and AF associated morbidity during development of a HFOG well site to which women, the elderly, and those with pre-existing health conditions are more susceptible. We will determine and compare the incidence of claims with a principle diagnosis of AF and AF related mortality in AF patients living within 1.6 km of a HFOG well site before, during, and after development of the site. The proposed study will be the first to evaluate relationships between the development of HFOG well sites and AF related morbidity. Findings from our study will allow us to determine if a cohort study is warranted and if warranted, inform the design of such a study. This future study would prospectively follow populations for AF and related morbidity over the course of development of HFOG well sites while measuring specific environmental risk factors associated with this development. Considering the rapidly growing number of people living in close proximity to an HFOG well set, it is essential that we work to understand the associated health risks as soon as possible so that we can develop the best preventions and remedies for those people. of HFOG sites may be at a significantly greater risk for additional incidents of AF and associated it is not known

项目总结/摘要 心房颤动（AF）是最常见和临床上显著的心律失常， 生活质量下降，中风、全身血栓栓塞和心力衰竭的风险大幅增加。我们 初步数据表明，居住在HFOG井场附近的人可能会经历血压升高 和动脉僵硬度与AF有关。水力压裂石油和天然气的开发 天然气（HFOG或“水力压裂”）井场与AF的两个新出现的环境风险因素有关，即空气和 噪音污染虽然这些证据表明居住在靠近心脏的房颤患者 发展 并发症，是如果空气和噪音污染，发生在发展过程中的HFOG以及 我们缺乏必要的初步数据来证明， 有效地设计前瞻性研究将是必要的，以解决迫切需要了解这些 病因关系。如果没有这些初步数据，我们就无法提出调查方法。 与HFOG井场和AF相关的环境风险之间的时间关系。我们的长期目标是 了解与HFOG和AF相关的环境风险之间的流行病学关系 相关的健康结果。本提案的总体目标是将科罗拉多所有付款人索赔联系起来 数据库（APCD）和科罗拉多O&G信息系统（COGIS）获取初步数据 证明和告知一项全面队列研究的设计是必要的。为达致这个目标，我们会 采用纵向中断时间序列交叉设计回顾性随访约2500名AF患者， APCD位于2010年至2015年开发的830个HFOG井场的1.6公里（1英里）范围内。我们 中心假设是，在房颤的发展过程中，房颤和房颤相关发病率的风险增加， HFOG井场，妇女、老年人和有健康问题的人更多 易受影响我们将确定并比较以房颤和房颤为主要诊断的索赔的发生率 HFOG井场1.6 km范围内的房颤患者在开发之前、期间和之后的相关死亡率 的网站。这项研究将首次评估HFOG的发展与 以及房颤相关的发病率。我们的研究结果将使我们能够确定一项队列研究是否 保证，如果保证，告知此类研究的设计。这项未来的研究将前瞻性地遵循 在HFOG井场开发过程中， 与这一发展相关的具体环境风险因素。考虑到快速增长的数字 对于生活在HFOG井附近的人们来说，我们必须努力了解 尽快消除相关的健康风险，以便我们能够开发出最好的预防和补救措施， 那些人 的HFOG站点可能面临更大的AF和相关事件的风险 目前还不知道