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USC Research Center for Liver Disease

南加州大学肝病研究中心

基本信息

批准号：
9882994
负责人：
Lucy Mary Golden
金额：
$ 112.71万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-03-01 至 2022-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9882994
关键词：
Achievement Acute Acute Liver Failure Administrator Biochemistry Cell Culture Techniques Cell Death Cell Separation Cells Cellular biology Cirrhosis Collaborations Core Facility Development Developmental Biology Diagnosis Digestive System Disorders Discipline Disease Equipment Faculty Fibrosis Fostering Funding Gerontology Goals Hepatocyte Hepatotoxicity High Pressure Liquid Chromatography Histology Home environment Immunohistochemistry Immunology Individual Inflammation Interdisciplinary Study Laboratories Life Liver Liver diseases Malignant neoplasm of liver Mass Spectrum Analysis Medicine Metabolic Microbiology Microscopy Mitochondria Molecular Biology Operative Surgical Procedures Outcome Pathogenesis Pathology Pharmacologic Substance Philosophy Postdoctoral Fellow Prevention Primary carcinoma of the liver cells Productivity Proteomics Public Health Regenerative Medicine Research Research Personnel Science Services Stains Steatohepatitis Talents Technology Tissue imaging Training United States National Institutes of Health Viral hepatitis Vision base career development cellular imaging chronic liver disease clinical investigation clinical translation cost effective economic cost imaging facilities improved innovation instrumentation interest liver injury member nonalcoholic steatohepatitis operation pediatric pharmacology problem drinker programs public health relevance repaired special interest group stem cell biology success symposium

项目摘要

DESCRIPTION, OVERALL (provided by applicant): The USC Research Center for Liver Disease (RCLD), which was founded in 1995, is dedicated to fostering and facilitating the collaborative research of its 57 current members and the career development of junior faculty through provision of research technologies and fora for scientific exchange. Thirty-seven members contribute to a stable research base in excess of ten million dollars annually with a growing translational emphasis. The Specific Aims of the USC Research Center for Liver Disease are: 1) To provide the essential services offered by Biomedical Core facilities to facilitate the research of the membership to advance our understanding of the pathogenesis and treatment of liver and digestive disease; 2) To foster collaboration between Center members through the use of Cores, the enrichment program, and the Special Interest group; 3) To foster career development through availability of Biomedical Cores, enrichment program, and pilot/feasibility support and attract the talents of established investigators from other fields to apply their expertise to liver and digestive disease research and to collaborate with Center members; 4) Facilitate the technological training and scientific development of postdoctoral fellows, K awardees and junior faculty through the services of the scientific cores, the enrichment program and pilot funding. The RCLD serves as the focal point for the interaction of a large number of faculty conducting research to advance our understating of the pathogenesis, prevention and treatment of liver diseases. The Center focuses on research in Liver Disease with 4 major themes: 1) viral hepatitis and liver cancer, 2) steatohepatitis and fibrosis, 3) hepatotoxicity and mitochondrial pathobiology, 4) repair, regenerative medicine and developmental biology. The Center supports an Administrative Core, the hub for all Center activities, includes the Center Director [Kaplowitz], Associate Director [DeLeve], and Assistant Director [Ookhtens], Administrator [Vidrio], who constitute the Operations Committee, as well as an Executive Committee and External Scientific Advisory Board. The Enrichment Program sponsors seminars, an annual symposium and research mini-symposia. The Pilot/Feasibility Project Program preferentially funds innovative new projects of young investigators which are relevant to the Center's themes. The Center has four scientific Cores: 1) Cell and Tissue Imaging (advanced microscopy), 2) Liver Histology (routine, special stains and immunohistochemistry), 3) Cell Separation and Culture (fluorescent cell sorting and liver cell culture), 4) Analytical (HPLC services), Metabolic (mitochondrial function), Instrumentation (shared central core equipment), and Proteomics Core (mass spectrometry).

总体描述(由申请者提供)：南加州大学肝病研究中心(RCLD)成立于1995年，致力于通过提供研究技术和科学交流论坛，促进和促进其57名现有成员的合作研究和初级教师的职业发展。37个成员每年为稳定的研究基地贡献超过1000万美元的资金，并越来越重视翻译。南加州大学肝病研究中心的具体目标是：1)提供生物医学核心设施所提供的基本服务，以促进成员的研究，以促进我们对肝脏和消化系统疾病的发病机制和治疗的了解；2)通过使用核心、丰富计划和特殊兴趣小组促进中心成员之间的合作；3)通过提供生物医学核心、丰富计划和试点/可行性支持来促进职业发展，并吸引来自其他领域的现有研究人员的人才将他们的专业知识应用于肝脏和消化系统疾病的研究，并与中心成员合作；4)通过科学核心服务、充实计划和试点资助，促进博士后研究员、K获奖者和初级教员的技术培训和科学发展。RCLD是大量从事研究的教师互动的焦点，以促进我们对肝脏疾病的发病机制、预防和治疗的低估。该中心专注于肝脏疾病的研究，主要有四个主题：1)病毒性肝炎和肝癌，2)脂肪性肝炎和纤维化，3)肝毒性和线粒体病理生物学，4)修复、再生医学和发育生物学。中心支持行政核心，这是中心所有活动的枢纽，包括组成业务委员会的中心主任[Kaplowitz]、副主任[DeLeve]和助理主任[Ookhten]、署长[Vidrio]，以及执行委员会和外部科学咨询委员会。丰富方案主办研讨会、年度专题讨论会和研究小型专题讨论会。试点/可行性项目方案优先资助与中心主题相关的年轻研究人员的创新新项目。该中心有四个科学核心：1)细胞和组织成像(高级显微镜)，2)肝组织学(常规、特殊染色和免疫组织化学)，3)细胞分离和培养(荧光细胞分类和肝细胞培养)，4)分析(高效液相色谱服务)，代谢(线粒体功能)，仪器(共享中央核心设备)和蛋白质组学核心(质谱学)。

项目成果

期刊论文数量（290）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.

DOI：
10.1038/onc.2013.437
发表时间：
2014-10-16
期刊：
Oncogene
影响因子：
8
作者：
通讯作者：

Clinical Significance of Ascitic Fluid Polymorphonuclear Leukocyte Percentage in Patients With Cirrhosis Without Spontaneous Bacterial Peritonitis.

DOI：
10.14309/ctg.0000000000000614
发表时间：
2023-09-01
期刊：
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
影响因子：
3.6
作者：
Dawit, Lillian;Lee, Vivian;Lehoang, David;Furey, Cameron;Chowdhury, Aneesa;Thu Anne Mai;Angajala, Varun;Park, Joo Hye;Khadarian, Kevork;She, Rosemary;Vergara-Lluri, Maria;Kahn, Jeffrey;Dodge, Jennifer L.;Saito, Takeshi
通讯作者：
Saito, Takeshi

Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells.