Pittsburgh Center for Kidney Research

肾在维持体内平衡中的关键作用，以及肾功能紊乱， 伴随肾脏疾病和相关肾功能丧失的体内平衡 强调了这个器官在人类健康中的重要性。生物医学领域的最新发展 科学已经导致我们对发病机制的理解有了重大进展， 特定的肾脏疾病，具有重要的诊断和治疗意义。目的 匹兹堡肾脏研究中心的使命是发展和促进多学科 与正常和疾病肾功能相关的研究、培训和信息传递 states.我们中心的主要目标是（i）提高我们关于正常的知识基础 肾功能，导致肾脏疾病的细胞机制以及许多改变的 在急性肾损伤和慢性肾病的情况下发生的细胞功能;（ii） 促进早期转化研究，包括使用动物模型的研究， 针对药物发现、开发和药代动力学的研究，以及支持 分析研究;以及（iii）提供所需的专门知识、培训和设备， 这些领域的研究工作。中心核心设施支撑百人工作， 匹兹堡大学、西奈山伊坎医学院的11名研究人员， 以及美国各地的其他机构。核心A是一个生理核心，由博士领导。 卡拉蒂诺和萨特林。核心B是动物和翻译核心，由杰克逊博士领导， 斯托克核心C是肾脏成像核心，由阿波达卡博士领导。核心D是一个模型系统， 由Brodsky和Hukriede博士领导的治疗核心。该中心支持四个试点和 可行性项目。由Kleyman和Weisz博士领导的行政核心提供 对核心设施、试点和可行性项目计划以及 中心的教育活动。所有研究核心都是专门为充当 调查人员的国家资源。我们的中心旨在实现我们的目标， 促进我们对正常肾功能的理解，有助于细胞机制， 肾脏疾病，以及在急性肾功能衰竭的情况下发生的许多细胞功能改变， 肾损伤和慢性肾病。

The critical role of the kidney in maintaining homeostatic balance, and the disorders of homeostasis that accompany diseases of the kidney and the associated loss of kidney function underscore the importance of this organ in human health. Recent developments in biomedical sciences have led to significant advancements in our understanding of the pathogenesis of specific renal diseases, which have important diagnostic and therapeutic implications. The Aim of our Pittsburgh Center for Kidney Research is to develop and facilitate multidisciplinary research, training and information transfer related to kidney function in normal and disease states. The major goals of our center are (i) to advance our knowledge base regarding normal kidney function, cellular mechanisms that contribute to kidney disease and the many altered cellular functions that occur in the settings of acute kidney injury and chronic kidney disease; (ii) to facilitate early-phase translational investigation, including studies using animal models, studies directed at drug discovery, development and pharmacokinetics, as well as support for analytical studies; and (iii) to provide the expertise, training and equipment needed to facilitate research activities in these areas. Center Core facilities support the work of one hundred and eleven investigators at the University of Pittsburgh, the Icahn School of Medicine at Mount Sinai, and at other institutions throughout the United States. Core A is a Physiology Core, led by Drs. Carattino and Satlin. Core B is an Animal and Translational Core, led by Drs. Jackson and Stocker. Core C is a Kidney Imaging Core, led by Dr. Apodaca. Core D is a Model Systems and Therapeutics Core, led by Drs. Brodsky and Hukriede. The Center supports four pilot and feasibility projects. An Administrative Core, led by Drs. Kleyman and Weisz, provides administrative oversight of the core facilities, the pilot and feasibility project program and the educational activities of the center. All research cores are specifically structured to serve as national resources for investigators. Our Center is designed to realize our goal of continuing to advance our understanding of normal renal function, of cellular mechanisms that contribute to kidney disease, and of the many altered cellular functions that occur in the settings of acute kidney injury and chronic kidney disease.