Pittsburgh Center for Kidney Research

肾脏在维持动态平衡中的关键作用，以及 伴随肾脏疾病和相关的肾功能丧失的动态平衡 强调这一器官对人类健康的重要性。生物医学的最新进展 科学的发展使我们对黄斑狼疮发病机制的认识有了显著的进步。 具体的肾脏疾病，具有重要的诊断和治疗意义。其目的是 我们匹兹堡肾脏研究中心的目标是发展和促进多学科 与正常和疾病肾功能相关的研究、训练和信息传递 各州。我们中心的主要目标是(I)推进我们关于正常的知识基础 肾功能、导致肾脏疾病的细胞机制和许多改变 在急性肾脏损伤和慢性肾脏疾病的情况下发生的细胞功能； 为了促进早期的翻译研究，包括使用动物模型进行研究， 针对药物发现、开发和药代动力学的研究，以及支持 分析研究；和(3)提供所需的专门知识、培训和设备，以促进 这些领域的研究活动。中心核心设施支撑百家亲民工作 匹兹堡大学、西奈山伊坎医学院的11名研究人员， 以及美国各地的其他机构。核心A是一个生理学核心，由博士领导。 卡拉蒂诺和萨特林。核心B是一个动物和翻译核心，由杰克逊博士和 斯托克。核心C是由Apodaca博士领导的肾脏成像核心。核心D是一个模型系统和 由Brodsky博士和Hukrieed博士领导的治疗核心公司。该中心支持四名飞行员和 可行性项目。由Kley man博士和Weisz博士领导的管理核心提供 对核心设施、试点和可行性项目方案以及 中心的教育活动。所有研究核心都被专门构建为 为调查人员提供国家资源。我们的中心旨在实现我们继续 促进我们对正常肾功能的理解，对促进 肾脏疾病，以及在急性肾功能衰竭时发生的许多细胞功能改变 肾脏损伤和慢性肾脏疾病。

The critical role of the kidney in maintaining homeostatic balance, and the disorders of homeostasis that accompany diseases of the kidney and the associated loss of kidney function underscore the importance of this organ in human health. Recent developments in biomedical sciences have led to significant advancements in our understanding of the pathogenesis of specific renal diseases, which have important diagnostic and therapeutic implications. The Aim of our Pittsburgh Center for Kidney Research is to develop and facilitate multidisciplinary research, training and information transfer related to kidney function in normal and disease states. The major goals of our center are (i) to advance our knowledge base regarding normal kidney function, cellular mechanisms that contribute to kidney disease and the many altered cellular functions that occur in the settings of acute kidney injury and chronic kidney disease; (ii) to facilitate early-phase translational investigation, including studies using animal models, studies directed at drug discovery, development and pharmacokinetics, as well as support for analytical studies; and (iii) to provide the expertise, training and equipment needed to facilitate research activities in these areas. Center Core facilities support the work of one hundred and eleven investigators at the University of Pittsburgh, the Icahn School of Medicine at Mount Sinai, and at other institutions throughout the United States. Core A is a Physiology Core, led by Drs. Carattino and Satlin. Core B is an Animal and Translational Core, led by Drs. Jackson and Stocker. Core C is a Kidney Imaging Core, led by Dr. Apodaca. Core D is a Model Systems and Therapeutics Core, led by Drs. Brodsky and Hukriede. The Center supports four pilot and feasibility projects. An Administrative Core, led by Drs. Kleyman and Weisz, provides administrative oversight of the core facilities, the pilot and feasibility project program and the educational activities of the center. All research cores are specifically structured to serve as national resources for investigators. Our Center is designed to realize our goal of continuing to advance our understanding of normal renal function, of cellular mechanisms that contribute to kidney disease, and of the many altered cellular functions that occur in the settings of acute kidney injury and chronic kidney disease.