Pittsburgh Center for Kidney Research

匹兹堡肾脏研究中心

• 批准号: 7883976
• 负责人: Thomas R Kleyman
• 金额: $ 23.68万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-11 至 2010-08-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7883976
• 关键词: Animal Model; Area; Biochemistry; Biological; Biological Sciences; Biomedical Research; Cell physiology; Cells; Cellular biology; Collaborations; Communities; Core Facility; Development; Diagnosis; Disease; Electrolyte Balance; Electrolytes; Epithelial; Equilibrium; Faculty; Functional disorder; Funding; Future; Gene-Modified; Goals; Homeostasis; Image; Individual; Interdisciplinary Study; Investigation; Kidney; Kidney Diseases; Kidney Failure; Knowledge; Liquid substance; Maintenance; Medicine; Molecular Genetics; Nephrons; Organ; Pathology; Pharmacology; Physiological; Physiology; Productivity; Proteins; Recording of previous events; Renal function; Research; Research Personnel; Research Project Grants; Research Training; Resources; Role; Science; Scientist; Structure; United States; Universities; Urinary tract; Work; career; design; equilibration disorder; medical schools; member; novel; pediatric department; programs; tool

DESCRIPTION, OVERALL (provided by applicant): The critical role of the kidney in maintaining fluid and electrolyte balance, and the disorders of homeostasis that are accompany diseases of the kidney and associated loss of renal function underscore the importance of this organ. Our increasing ability to both identify and modify the gene products that are responsible for maintaining normal homeostatic balance offers new and powerful approaches to examine the contributions of individual proteins to the maintenance of normal renal function and the consequences of loss of renal function. The objective of the Pittsburgh Center for Kidney Research is to both reinforce and expand interactions among investigators at the University of Pittsburgh and colleagues at Mount Sinai School of Medicine who have had a longstanding history of research in areas related to the identification and characterization of cellular processes within the kidney that are associated with normal physiology and with pathophysiological states, to develop new directions of investigation using electrophysiological, cell biological, molecular, and genetic tools, and to attract new investigators to renal-related research. The Center will be focused on four main cores, which will support the work of investigators at the University of Pittsburgh and Mount Sinai School of Medicine. Core A is a cellular physiology core, led by Dr. Johnson. Core B is a single nephron and organ physiology core, led by Drs. Jackson and Satlin. Core C is a urinary tract epithelial imaging core, led by Dr. Apodaca. Core D will focus on the use of model organisms to elucidate novel aspects of kidney function and is led by Drs. Brodsky and Hukriede. The Center will support three pilot and feasibility projects. An administrative core, led by Drs. Kleyman and Weisz, will provide administrative oversight of the core facilities, the pilot and feasibility project program and the instructional components of the center. All research cores are specifically structured to serve as nation-wide resources for investigators. Our Center is designed to realize our goal of continuing to advance our understanding of normal renal function, of cellular mechanisms that contribute to kidney disease, and of the myriad altered cellular functions that occur in the setting of renal insufficiency.

描述，总体（由申请人提供）： 肾脏在维持液体和电解质平衡方面的关键作用，以及伴随肾脏疾病的稳态疾病以及肾功能的相关损失强调了该器官的重要性。我们越来越多地识别和修改负责维持正常稳态平衡的基因产品的能力，提供了新的强大方法，可以检查单个蛋白质对维持正常肾功能的贡献以及肾功能丧失的后果。匹兹堡肾脏研究中心的目的是增强和扩大匹兹堡大学的研究人员之间的互动和西奈山医学院的同事，他们在与肾脏内的细胞和摩尔病理学的摩尔学典范中相关的肾脏识别和表征相关的细胞识别和表征相关的细胞识别和表征的研究领域具有长期的研究历史。遗传工具，并吸引新的研究人员参与肾脏相关的研究。该中心将集中在四个主要核心上，该核心将支持匹兹堡大学和西奈山医学院的调查人员工作。核心A是约翰逊博士领导的细胞生理核心。 Core B是由Drs领导的单个肾单位和器官生理核心。杰克逊和萨特林。 Core C是由Apodaca博士领导的尿路上皮成像核心。核心D将集中于使用模型生物来阐明肾功能的新方面，并由DRS领导。布罗德斯基和霍克里德。该中心将支持三个飞行员和可行性项目。由Drs领导的行政核心。克莱曼（Kleyman）和魏斯（Weisz）将对核心设施，飞行员和可行性项目计划以及中心的教学组件提供行政监督。所有研究核心均专门为研究人员提供全国资源。我们的中心旨在实现我们的目标，即继续提高我们对正常肾功能的理解，对肾脏疾病的细胞机制以及在肾功能不全的情况下发生的无数细胞功能发生的改变。