Pittsburgh Center for Kidney Research

匹兹堡肾脏研究中心

• 批准号: 7883976
• 负责人: Thomas R Kleyman
• 金额: $ 23.68万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-11 至 2010-08-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7883976
• 关键词: Animal Model; Area; Biochemistry; Biological; Biological Sciences; Biomedical Research; Cell physiology; Cells; Cellular biology; Collaborations; Communities; Core Facility; Development; Diagnosis; Disease; Electrolyte Balance; Electrolytes; Epithelial; Equilibrium; Faculty; Functional disorder; Funding; Future; Gene-Modified; Goals; Homeostasis; Image; Individual; Interdisciplinary Study; Investigation; Kidney; Kidney Diseases; Kidney Failure; Knowledge; Liquid substance; Maintenance; Medicine; Molecular Genetics; Nephrons; Organ; Pathology; Pharmacology; Physiological; Physiology; Productivity; Proteins; Recording of previous events; Renal function; Research; Research Personnel; Research Project Grants; Research Training; Resources; Role; Science; Scientist; Structure; United States; Universities; Urinary tract; Work; career; design; equilibration disorder; medical schools; member; novel; pediatric department; programs; tool

DESCRIPTION, OVERALL (provided by applicant): The critical role of the kidney in maintaining fluid and electrolyte balance, and the disorders of homeostasis that are accompany diseases of the kidney and associated loss of renal function underscore the importance of this organ. Our increasing ability to both identify and modify the gene products that are responsible for maintaining normal homeostatic balance offers new and powerful approaches to examine the contributions of individual proteins to the maintenance of normal renal function and the consequences of loss of renal function. The objective of the Pittsburgh Center for Kidney Research is to both reinforce and expand interactions among investigators at the University of Pittsburgh and colleagues at Mount Sinai School of Medicine who have had a longstanding history of research in areas related to the identification and characterization of cellular processes within the kidney that are associated with normal physiology and with pathophysiological states, to develop new directions of investigation using electrophysiological, cell biological, molecular, and genetic tools, and to attract new investigators to renal-related research. The Center will be focused on four main cores, which will support the work of investigators at the University of Pittsburgh and Mount Sinai School of Medicine. Core A is a cellular physiology core, led by Dr. Johnson. Core B is a single nephron and organ physiology core, led by Drs. Jackson and Satlin. Core C is a urinary tract epithelial imaging core, led by Dr. Apodaca. Core D will focus on the use of model organisms to elucidate novel aspects of kidney function and is led by Drs. Brodsky and Hukriede. The Center will support three pilot and feasibility projects. An administrative core, led by Drs. Kleyman and Weisz, will provide administrative oversight of the core facilities, the pilot and feasibility project program and the instructional components of the center. All research cores are specifically structured to serve as nation-wide resources for investigators. Our Center is designed to realize our goal of continuing to advance our understanding of normal renal function, of cellular mechanisms that contribute to kidney disease, and of the myriad altered cellular functions that occur in the setting of renal insufficiency.

总体描述（由申请人提供）： 肾脏在维持体液和电解质平衡中的关键作用，以及伴随肾脏疾病和相关肾功能丧失的体内平衡障碍强调了该器官的重要性。我们越来越多的能力，以确定和修改的基因产物，负责维持正常的稳态平衡提供了新的和强大的方法来检查的贡献，个别蛋白质的正常肾功能的维持和肾功能丧失的后果。匹兹堡肾脏研究中心的目标是加强和扩大匹兹堡大学的研究人员和西奈山医学院的同事之间的互动，他们在与正常生理和病理生理状态相关的肾脏内细胞过程的识别和表征相关的领域有着悠久的研究历史，利用电生理学、细胞生物学、分子学和遗传学工具开发新的研究方向，并吸引新的研究人员进行肾脏相关研究。该中心将专注于四个主要核心，这将支持匹兹堡大学和西奈山医学院的研究人员的工作。核心A是一个细胞生理学核心，由约翰逊博士领导。核心B是一个单一的肾单位和器官生理核心，由杰克逊博士和萨特林博士领导。核心C是尿路上皮成像核心，由阿波达卡博士领导。核心D将专注于使用模式生物来阐明肾功能的新方面，由Brodsky和Hukriede博士领导。该中心将支持三个试点和可行性项目。一个由Kleyman博士和Weisz博士领导的行政核心将对中心的核心设施、试点和可行性项目计划以及教学部分进行行政监督。所有的研究核心都是专门为研究人员提供全国性的资源。我们的中心旨在实现我们的目标，继续推进我们对正常肾功能，导致肾脏疾病的细胞机制以及肾功能不全环境中发生的无数改变的细胞功能的理解。