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Pittsburgh Center for Kidney Research

匹兹堡肾脏研究中心

基本信息

批准号：
8734385
负责人：
Thomas R Kleyman
金额：
$ 116.74万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8734385
关键词：
Animal Model Area Biological Biological Sciences Biology Biomedical Research Cell physiology Cells Cellular biology Chemicals Collaborations Communities Core Facility Critical Care Development Developmental Biology Diagnosis Disease Educational Activities Electrolyte Balance Electrolytes Equilibrium Faculty Fluid Balance Functional disorder Gene-Modified Genetic Goals Homeostasis Individual Instruction Interdisciplinary Study International Investigation Kidney Kidney Diseases Kidney Failure Knowledge Maintenance Medicine Microbiology Molecular Molecular Genetics Nephrology Nephrons Organ Pathology Pharmacology Physiological Physiology Productivity Proteins Recording of previous events Renal function Research Research Personnel Research Project Grants Research Training Resources Role Science Scientist Structure United States Universities Work career data acquisition design equilibration disorder kidney imaging knowledge base medical schools member metabolomics pediatric department programs tool

项目摘要

PROJECT SUMMARY (See Instructions): The critical role of the kidney in maintaining fluid and electrolyte balance, and the disorders of homeostasis that are accompany diseases of the kidney and associated loss of renal function underscore the importance of this organ. Our increasing ability to both identify and modify the gene products that are responsible for maintaining normal homeostatic balance offers new and powerful approaches to examine the contributions of individual proteins to the maintenance of normal renal function and the consequences of loss of renal function. The objective of the Pittsburgh Center for Kidney Research is to both reinforce and expand interactions among investigators at the University of Pittsburgh and colleagues at Mount Sinai School of Medicine who have had a longstanding history of research in areas related to the identification and characterization of cellular processes within the kidney that are associated with normal physiology and with path physiological states, to develop new directions of investigation using electrophysiological, cell biological, molecular, and genetic tools, and to attract new investigators to renal-related research. The Center will be focused on four main cores, which will support the work of investigators at the University of Pittsburgh and Mount Sinai School of Medicine. Core A is a cellular physiology core, led by Dr. Hallows. Core B is a single nephron and metabolomics core, led by Drs. Jackson and Satlin. Core C is a kidney imaging core, led by Dr. Apodaca. Core D will focus on the use of model organisms and is led by Drs. Brodsky and Hukriede. The Center will support four pilot and feasibility projects. An administrative core, led by Drs. Kleyman and Weisz, will provide administrative oversight of the core facilities, the pilot and feasibility project program and the educational activities of the center. All research cores are specifically structured to serve as nation-wide resources for investigators. Our Center is designed to realize our goal of continuing to advance our understanding of normal renal function, of cellular mechanisms that contribute to kidney disease, and of the myriad of altered cellular functions that occur in the setting of renal insufficiency.

项目概述（见项目说明）：