Pittsburgh Center for Kidney Research

项目摘要（参见说明）： 肾脏在维持液体和电解质平衡中的关键作用以及伴随肾脏疾病和相关肾功能丧失的体内平衡紊乱强调了该器官的重要性。我们识别和修改负责维持正常稳态平衡的基因产物的能力不断增强，这提供了新的、强大的方法来检查单个蛋白质对维持正常肾功能的贡献以及肾功能丧失的后果。匹兹堡肾脏研究中心的目标是加强和扩大匹兹堡大学研究人员与西奈山医学院同事之间的互动，他们在肾脏内与正常生理和路径生理状态相关的细胞过程的识别和表征相关领域有着悠久的研究历史，利用电生理学、细胞生物学、分子和遗传工具开发新的研究方向，并吸引新的研究人员进行肾脏相关研究。该中心将专注于四个主要核心，这将支持匹兹堡大学和西奈山医学院研究人员的工作。核心 A 是细胞生理学核心，由 Hallows 博士领导。核心 B 是一个单一肾单位和代谢组学核心，由 Drs. 领导。杰克逊和萨特林。 Core C 是一个肾脏成像核心，由 Apodaca 博士领导。核心 D 将重点关注模型生物体的使用，由 Drs. 领导。布罗茨基和胡克里德。该中心将支持四个试点和可行性项目。由博士领导的行政核心。克莱曼和魏斯将对中心的核心设施、试点和可行性项目计划以及教育活动进行行政监督。所有研究核心都经过专门构建，为研究人员提供全国范围的资源。我们中心旨在实现我们的目标，即继续增进我们对正常肾功能、导致肾脏疾病的细胞机制以及肾功能不全情况下发生的无数细胞功能改变的理解。

PROJECT SUMMARY (See Instructions): The critical role of the kidney in maintaining fluid and electrolyte balance, and the disorders of homeostasis that are accompany diseases of the kidney and associated loss of renal function underscore the importance of this organ. Our increasing ability to both identify and modify the gene products that are responsible for maintaining normal homeostatic balance offers new and powerful approaches to examine the contributions of individual proteins to the maintenance of normal renal function and the consequences of loss of renal function. The objective of the Pittsburgh Center for Kidney Research is to both reinforce and expand interactions among investigators at the University of Pittsburgh and colleagues at Mount Sinai School of Medicine who have had a longstanding history of research in areas related to the identification and characterization of cellular processes within the kidney that are associated with normal physiology and with path physiological states, to develop new directions of investigation using electrophysiological, cell biological, molecular, and genetic tools, and to attract new investigators to renal-related research. The Center will be focused on four main cores, which will support the work of investigators at the University of Pittsburgh and Mount Sinai School of Medicine. Core A is a cellular physiology core, led by Dr. Hallows. Core B is a single nephron and metabolomics core, led by Drs. Jackson and Satlin. Core C is a kidney imaging core, led by Dr. Apodaca. Core D will focus on the use of model organisms and is led by Drs. Brodsky and Hukriede. The Center will support four pilot and feasibility projects. An administrative core, led by Drs. Kleyman and Weisz, will provide administrative oversight of the core facilities, the pilot and feasibility project program and the educational activities of the center. All research cores are specifically structured to serve as nation-wide resources for investigators. Our Center is designed to realize our goal of continuing to advance our understanding of normal renal function, of cellular mechanisms that contribute to kidney disease, and of the myriad of altered cellular functions that occur in the setting of renal insufficiency.