Pittsburgh Center for Kidney Research

项目总结(见说明)： 肾脏在维持液体和电解质平衡中的关键作用，以及伴随肾脏疾病和相关的肾功能丧失的动态平衡紊乱，突出了该器官的重要性。我们识别和修饰负责维持正常内环境平衡的基因产物的能力日益增强，这为研究单个蛋白质对维持正常肾功能的贡献和肾功能丧失的后果提供了新的和强大的方法。匹兹堡肾脏研究中心的目标是加强和扩大匹兹堡大学的研究人员和西奈山医学院的同事之间的互动，他们在与肾脏内与正常生理和路径生理状态相关的细胞过程的识别和表征方面有着长期的研究历史，利用电生理学、细胞生物学、分子和遗传学工具开发新的研究方向，并吸引新的研究人员参与与肾脏相关的研究。该中心将专注于四个主要核心，这将支持匹兹堡大学和西奈山医学院的研究人员的工作。核心A是一个细胞生理学核心，由哈洛斯博士领导。核心B是由杰克逊博士和萨特林博士领导的单一肾单位和代谢组学核心。核心C是由阿波达卡博士领导的肾脏成像核心。核心D将专注于模式生物的使用，由布罗德斯基博士和赫克里埃德博士领导。该中心将支持四个试点和可行性项目。由Kley man博士和Weisz博士领导的行政核心将对中心的核心设施、试点和可行性项目计划以及教育活动进行行政监督。所有的研究核心都是专门为调查人员提供的全国性资源。我们的中心旨在实现我们的目标，即继续提高我们对正常肾功能、导致肾脏疾病的细胞机制以及在肾功能不全背景下发生的无数细胞功能变化的了解。

PROJECT SUMMARY (See Instructions): The critical role of the kidney in maintaining fluid and electrolyte balance, and the disorders of homeostasis that are accompany diseases of the kidney and associated loss of renal function underscore the importance of this organ. Our increasing ability to both identify and modify the gene products that are responsible for maintaining normal homeostatic balance offers new and powerful approaches to examine the contributions of individual proteins to the maintenance of normal renal function and the consequences of loss of renal function. The objective of the Pittsburgh Center for Kidney Research is to both reinforce and expand interactions among investigators at the University of Pittsburgh and colleagues at Mount Sinai School of Medicine who have had a longstanding history of research in areas related to the identification and characterization of cellular processes within the kidney that are associated with normal physiology and with path physiological states, to develop new directions of investigation using electrophysiological, cell biological, molecular, and genetic tools, and to attract new investigators to renal-related research. The Center will be focused on four main cores, which will support the work of investigators at the University of Pittsburgh and Mount Sinai School of Medicine. Core A is a cellular physiology core, led by Dr. Hallows. Core B is a single nephron and metabolomics core, led by Drs. Jackson and Satlin. Core C is a kidney imaging core, led by Dr. Apodaca. Core D will focus on the use of model organisms and is led by Drs. Brodsky and Hukriede. The Center will support four pilot and feasibility projects. An administrative core, led by Drs. Kleyman and Weisz, will provide administrative oversight of the core facilities, the pilot and feasibility project program and the educational activities of the center. All research cores are specifically structured to serve as nation-wide resources for investigators. Our Center is designed to realize our goal of continuing to advance our understanding of normal renal function, of cellular mechanisms that contribute to kidney disease, and of the myriad of altered cellular functions that occur in the setting of renal insufficiency.