Pittsburgh Center for Kidney Research

匹兹堡肾脏研究中心

基本信息

批准号：
8734385
负责人：
Thomas R Kleyman
金额：
$ 116.74万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8734385
关键词：
Animal Model Area Biological Biological Sciences Biology Biomedical Research Cell physiology Cells Cellular biology Chemicals Collaborations Communities Core Facility Critical Care Development Developmental Biology Diagnosis Disease Educational Activities Electrolyte Balance Electrolytes Equilibrium Faculty Fluid Balance Functional disorder Gene-Modified Genetic Goals Homeostasis Individual Instruction Interdisciplinary Study International Investigation Kidney Kidney Diseases Kidney Failure Knowledge Maintenance Medicine Microbiology Molecular Molecular Genetics Nephrology Nephrons Organ Pathology Pharmacology Physiological Physiology Productivity Proteins Recording of previous events Renal function Research Research Personnel Research Project Grants Research Training Resources Role Science Scientist Structure United States Universities Work career data acquisition design equilibration disorder kidney imaging knowledge base medical schools member metabolomics pediatric department programs tool

项目摘要

PROJECT SUMMARY (See Instructions): The critical role of the kidney in maintaining fluid and electrolyte balance, and the disorders of homeostasis that are accompany diseases of the kidney and associated loss of renal function underscore the importance of this organ. Our increasing ability to both identify and modify the gene products that are responsible for maintaining normal homeostatic balance offers new and powerful approaches to examine the contributions of individual proteins to the maintenance of normal renal function and the consequences of loss of renal function. The objective of the Pittsburgh Center for Kidney Research is to both reinforce and expand interactions among investigators at the University of Pittsburgh and colleagues at Mount Sinai School of Medicine who have had a longstanding history of research in areas related to the identification and characterization of cellular processes within the kidney that are associated with normal physiology and with path physiological states, to develop new directions of investigation using electrophysiological, cell biological, molecular, and genetic tools, and to attract new investigators to renal-related research. The Center will be focused on four main cores, which will support the work of investigators at the University of Pittsburgh and Mount Sinai School of Medicine. Core A is a cellular physiology core, led by Dr. Hallows. Core B is a single nephron and metabolomics core, led by Drs. Jackson and Satlin. Core C is a kidney imaging core, led by Dr. Apodaca. Core D will focus on the use of model organisms and is led by Drs. Brodsky and Hukriede. The Center will support four pilot and feasibility projects. An administrative core, led by Drs. Kleyman and Weisz, will provide administrative oversight of the core facilities, the pilot and feasibility project program and the educational activities of the center. All research cores are specifically structured to serve as nation-wide resources for investigators. Our Center is designed to realize our goal of continuing to advance our understanding of normal renal function, of cellular mechanisms that contribute to kidney disease, and of the myriad of altered cellular functions that occur in the setting of renal insufficiency.

项目摘要（请参阅说明）：肾脏在维持液体和电解质平衡方面的关键作用，以及伴随肾脏疾病的稳态疾病以及肾功能的相关损失强调了该器官的重要性。我们越来越多地识别和修改负责维持正常稳态平衡的基因产品的能力，提供了新的强大方法，可以检查单个蛋白质对维持正常肾功能的贡献以及肾功能丧失的后果。匹兹堡肾脏研究中心的目标是，匹兹堡大学和西奈山医学院的同事之间的研究人员之间的相互作用和扩大相互作用，他们在与肾脏内的肾脏和旋转式的遗传学状态相关的肾脏识别和表征相关的细胞中的细胞识别和表征相关的细胞和跨性别型的研究方面具有长期的研究历史工具，并吸引新的研究人员进行肾脏有关的研究。该中心将集中在四个主要核心上，该核心将支持匹兹堡大学和西奈山医学院的调查人员工作。核心A是Hallows博士领导的细胞生理核心。 Core B是由DRS领导的单个肾单位和代谢组学核心。杰克逊和萨特林。 Core C是由Apodaca博士领导的肾脏成像核心。核心D将专注于模型生物的使用，并由DRS领导。布罗德斯基和霍克里德。该中心将支持四个飞行员和可行性项目。由Drs领导的行政核心。克莱曼（Kleyman）和魏斯（Weisz）将对核心设施，试点和可行性项目计划以及中心的教育活动提供行政监督。所有研究核心均专门为研究人员提供全国资源。我们的中心旨在实现我们的目标，即继续促进对正常肾功能的理解，对肾脏疾病的细胞机制以及在肾功能不全的情况下发生的无数细胞功能的改变。