Training Program in Free Radical and Radiation Biology

自由基和放射生物学培训计划

• 批准号: 9753115
• 负责人: Douglas Robert Spitz
• 金额: $ 27.68万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753115
• 关键词: Free Radicals; Radiobiology; Training Programs

 DESCRIPTION (provided by applicant): The Free Radical and Radiation Biology Training Program in Radiation Oncology at the University of Iowa was established to provide interdisciplinary graduate and post-graduate training with a focus on six key goals for education in preparation of trainees for careers in cancer-related fields within biomedical research and education: 1)To impart a fundamental understanding of the subject matter of radiation biology, free radical biology, and cancer biology; 2) To provide trainees with the opportunity to achieve proficiency in the experimental radiation biology, free radical biology, and molecular oncology disciplines leading to successful careers in cancer research; 3) To structure research experiences for trainees that include the development of a research proposal, execution of a research project, and evaluation of scientific results for submission to peer- reviewed journals; 4) To offer trainees experiences in learning skills necessary to do collaborative research with faculty in both clinical and basic science departments to translate fundamental mechanistic knowledge in free radical and radiation biology from the bench-to-bedside; 5) To provide trainees with the critical thinking and skills necessary to effectively communicate scientific knowledge in both oral and written presentations of their research; and 6) To encourage trainees to implement innovative approaches in a "real world" environment to test, using hypothesis driven research techniques, the basic mechanisms underlying radiobiological and redox biology phenomena as they relate to cancer biology with an emphasis on developing novel interventions to limit the health related impact of cancer. We are proposing to support three predoctoral and three postdoctoral trainees per year. We have an internationally recognized faculty with a consistent track record of success in radiobiology and free radical cancer biology investigator initiated research awards as well as publications. We propose to have 13 well- funded and dedicated program faculty members (both junior and senior faculty ranks) that embrace a diverse body of knowledge that synergistically comprises the interdisciplinary program in Free Radical and Radiation Biology at the University of Iowa. The 13 program faculty members consist of 7 Professors, 3 Associate Professors, and 3 Assistant Professors of which 4 are from Radiation Oncology, 3 from Internal Medicine, 2 from Biochemistry, and 1 each from Pathology, Psychiatry/Neurology, Radiology, and Surgery. Educational activities for trainees includes one-on-one mentoring by faculty, cancer-related nationally recognized research projects, presenting work and receiving feedback at national meetings, 2 journal clubs/week, 1 seminar/week, 1 translational research meeting/week, and technical training in the state of-the-art core lab resources in the program. Formal graduate level coursework offered by the faculty (required for pre-docs) includes classes in radiation, free radical, and cancer biology as well as a course in medical physics with an emphasis on image guided cancer therapy. The interdisciplinary cancer related research being pursued by the faculty spans a wide spectrum from basic mechanistic studies to translational preclinical as well as clinical studies. The program has a 50+ year history of producing outstanding scientists working in cancer research and free radical biology.

 描述(由申请人提供)：爱荷华大学放射肿瘤学的自由基和辐射生物学培训计划是为了提供跨学科的研究生和研究生培训，重点是六个关键的教育目标，为学员在生物医学研究和教育中的癌症相关领域的职业做准备：1)传授辐射生物学、自由基生物学和癌症生物学的基本知识；2)为学员提供机会，使他们精通实验辐射生物学、自由基生物学和分子肿瘤学学科，从而在癌症研究中取得成功；3)为受训者构建研究经验，包括制定研究方案、执行研究项目和评估提交给同行评审期刊的科学结果；4)为受训者提供学习必要技能的经验，以便与临床和基础科学系的教员进行合作研究，将自由基和辐射生物学的基本机制知识从工作台翻译到床边；5)为受训者提供必要的批判性思维和技能，以有效地在口头和书面陈述他们的研究中交流科学知识；6)鼓励受训者在“真实世界”环境中采用创新方法，利用假设驱动的研究技术，测试放射生物学和氧化还原生物学现象与癌症生物学有关的基本机制，重点是开发新的干预措施，以限制癌症对健康的影响。我们建议每年支持三名博士后和三名博士后实习生。我们拥有一支国际公认的教师队伍，在放射生物学和自由基癌症生物学研究者发起的研究奖项以及出版物方面有着始终如一的成功记录。我们建议有13名资金充足和敬业的计划教员(包括初级和高级教职员工)，他们接受不同的知识体系，协同组成爱荷华大学自由基和辐射生物学的跨学科计划。该项目的13名教职员工包括7名教授、3名副教授和3名助理教授，其中4名来自放射肿瘤学，3名来自内科，2名来自生物化学，1名来自病理学、精神病学/神经病学、放射学和外科。对学员的教育活动包括教师一对一的指导，与癌症相关的国家认可的研究项目，在全国会议上展示工作并接受反馈，2个期刊俱乐部/周，1个研讨会/周，1个翻译研究会议/周，以及项目中最先进的核心实验室资源的技术培训。正规研究生水平 该学院提供的课程包括辐射、自由基和癌症生物学课程，以及侧重于图像引导癌症治疗的医学物理学课程。教师们正在进行的跨学科癌症相关研究涵盖了从基础机制研究到转化性临床前研究以及临床研究的广泛领域。该项目已有50多年的历史，培养出从事癌症研究和自由基生物学工作的杰出科学家。