An Integrative Science Approach to Resilience: The Notre Dame Study of Health & Well-being

项目摘要 这项建议旨在调查生活压力导致抑郁症的无数途径。 认知，身体和心理健康在整个成年人的生命周期，以及弹性机制， 保护个人免受逆境的不良影响。我们计划收集面对面的认知和 来自参加圣母大学健康与福祉研究的##人的健康数据， 拥有至少7年的纵向问卷数据和4次56天的每日日记数据。第二 目的是增加一个实验室为基础的实验应力操纵试点a）最佳方法， 实验性地操纵应激，B）评估随后对生理系统的破坏 受压力影响（例如，皮质醇、α-淀粉酶、心率、面部表情），以及c）应对的评估 资源，区分压力反应的调节。我们将利用这一独特的科学价值 NDHWB致力于对整个成年期的风险和复原力进行广泛的研究。

Project Summary This proposal is designed to investigate the myriad pathways through which life stress contributes to the cognitive, physical and mental health across the adult lifespan, and of the resilience mechanisms that may protect individuals from the ill-effects of exposure to adversity. We plan to collect in-person cognitive and health data from ## individuals participating in the Notre Dame Study of Health & Well-Being (NDHWB) who have at least 7 years of longitudinal questionnaire data and 4 bursts of 56-day daily diary data. A second objective is to add a laboratory-based experimental stress manipulation to pilot a) optimal methods to experimentally manipulate stress, b) the assessment of subsequent disruption to physiological systems affected by stress (e.g., cortisol, alpha amylase, heart rate, facial expressions), and c) the appraisal of coping resources that differentiate the regulation of stress response. We will capitalize on the unique scientific value of the NDHWB to pursue a broad agenda of research on risk and resilience across adulthood.