An Integrative Science Approach to Resilience: The Notre Dame Study of Health & Well-being

摘要-UH3057039 NDHWB提供了纵向研究设计和强大的分析策略，可以帮助研究人员了解压力暴露、评估、反应性、抵抗力和恢复等相互关联的主题，从而了解生理应激反应在认知障碍中的作用，最终导致阿尔茨海默病和相关痴呆。要了解阿尔茨海默病的前兆，需要的是与阿尔茨海默病相关的基因类型的明确数据、大脑的结构图像、淀粉样蛋白-β水平以及认知任务期间的大脑功能指标(使用TM-EEG)。总之，这项拟议的研究提供了一个前所未有的机会，可以用多种方法研究成年人面临的压力源、他们所依赖的抵抗力来源，以及压力表现出来并最终导致生理调节障碍、认知能力下降和阿尔茨海默病发展的情绪和生理过程。

Abstract – UH3057039 The NDHWB provides a longitudinal research design and powerful analytic strategies that can help researchers understand the interrelated themes of stress exposure, appraisal, reactivity, resistance, and recovery, thereby informing the role of the physiological stress response in cognitive impairment, and ultimately Alzheimer’s disease and Related Dementias. What is needed to understand the precursors of Alzheimer’s disease is explicit data on genotypes associated with Alzheimer’s disease, structural images of the brain, levels of Amyloid-β and indicators of brain functioning (using TMS-EEG) during cognitive tasks. In confluence, the proposed research provides an unprecedented opportunity to study with multiple methods the stressors to which adults are exposed, the resistance resources upon which they draw, and the emotional and physiological processes through which stress is manifested and eventually contribute to physiological dysregulation, cognitive decline and the development of Alzheimer’s disease.