An Integrative Science Approach to Resilience: The Notre Dame Study of Health & Well-being

恢复力的综合科学方法：圣母大学健康研究

基本信息

批准号：
10289024
负责人：
Cindy S Bergeman
金额：
$ 38.97万
依托单位：
UNIVERSITY OF NOTRE DAME
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10289024
关键词：
Activities of Daily Living Address Administrative Supplement Adult Affective Alleles Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Alzheimer’s disease biomarker Amyloid beta-Protein Anatomy Apolipoproteins Biological Biological Assay Biological Markers Blood Blood Circulation Brain Brain imaging Cardiac health Cholesterol Clinical Cognition Cognitive Consensus Data Data Set Dementia Development Early identification Elderly Electroencephalography Emotional Evaluation Family health status Fatty acid glycerol esters Gene-Modified Genes Genotype Gold Health Hippocampus (Brain)Hydrocortisone Immune Impaired cognition Individual Intervention Link Longitudinal Studies Magnetic Resonance Imaging Measurable Disease Measures Methods Neurologic Participant Patient Self-Report Personal Satisfaction Persons Pharmaceutical Preparations Physiological Physiological Processes Play Proteins Quality of life Recording of previous events Recovery Regulation Research Research Design Research Personnel Resistance Resources Respiration Risk Risk Factors Role Sampling Science Stress Structure Symptoms Thinness Time Transcranial magnetic stimulation Triglycerides United States National Institutes of Health aged apolipoprotein E-4 base biological adaptation to stress brain dysfunction clinically significant cognitive ability cognitive function cognitive task cohort coping design electrical potential genetic risk factor health data heart rate variability high risk indexing inflammatory marker innovation insight lifestyle factors longitudinal dataset middle age multimodality neuropathology neurophysiology parent project predictive marker relating to nervous system resilience response social factors stress reactivity stress resilience stressor successful intervention

项目摘要

Abstract – UH3057039 The NDHWB provides a longitudinal research design and powerful analytic strategies that can help researchers understand the interrelated themes of stress exposure, appraisal, reactivity, resistance, and recovery, thereby informing the role of the physiological stress response in cognitive impairment, and ultimately Alzheimer’s disease and Related Dementias. What is needed to understand the precursors of Alzheimer’s disease is explicit data on genotypes associated with Alzheimer’s disease, structural images of the brain, levels of Amyloid-β and indicators of brain functioning (using TMS-EEG) during cognitive tasks. In confluence, the proposed research provides an unprecedented opportunity to study with multiple methods the stressors to which adults are exposed, the resistance resources upon which they draw, and the emotional and physiological processes through which stress is manifested and eventually contribute to physiological dysregulation, cognitive decline and the development of Alzheimer’s disease.

摘要 - UH3057039 NDHWB提供了纵向研究设计和强大的分析策略，可以帮助研究人员了解压力暴露，评估，反应性，抵抗力和恢复的相互关联的主题，从而告知身体压力反应在认知障碍中的作用，并最终导致阿尔茨海默氏病和相关痴呆症。了解阿尔茨海默氏病的前体所需的是有关与阿尔茨海默氏病相关的基因型的明确数据，在认知任务期间，大脑的结构图像，淀粉样β水平的水平以及大脑功能的指标（使用TMS-EEG）。在汇合处，拟议的研究提供了一个前所未有的机会，可以通过多种方法进行研究，这些方法是成年人暴露的压力，他们绘制的抵抗力资源，以及压力表现出来的情感和身体过程，并最终导致生理失调，认知能力下降和认知能力下降以及阿尔茨海默氏病的发展。