Notre Dame Study of Health & Well-being

描述(由申请人提供)：这项建议是为了竞争性地更新圣母大学的健康和福祉研究(NDHWB；R01 AG023571)，以支持一项关于生活压力对成年人一生中的身心健康做出贡献的无数途径的调查，以及可能保护这些个人免受逆境影响的弹性机制的调查。现有的数据集在压力测量的丰富性方面是无与伦比的，这些数据跨越5年的多个时间点收集，包括5次年度问卷评估和3次56天的数据突发(第1年、第3年和第5年；两次在中年队列中)。这些数据使我们能够审查多种形式的逆境及其与随后的健康和福祉指标的共同和独特的联系。在目前的建议中，我们通过收集额外的纵向数据(将研究扩展到10年)来扩大研究范围，在晚年队列中增加2个额外的数据突发(第7年和第9年)，在中年队列中增加3个突发数据(第6年、第8年和第10年)。我们通过增加一个年轻人队列(18-40岁)来扩展研究范围，用5个年度问卷和3个数据突发(1、3和5岁)对他们进行评估，以更好地了解这些因素是如何在成年后发展和维持的。最后，我们建议在一组受试者(每个队列50人)上增加两次为期10天的皮质醇评估(收集3X天)，以捕捉对压力的生理反应。扩大项目的总体目标有两个：全面和准确地详细说明可能引发可能导致紊乱和疾病的感知、情感和生物反应的生活压力的类型和质量，并检查防止它们的复原力资源。 公共卫生相关性：在这一竞争性更新中，我们建议扩大并显著加强巴黎圣母院健康与福祉研究(NDHWB)，包括(1)再进行5年的密集纵向评估(包括5年的年度评估和两次单独的56天突发(3次中年)，最终将产生10年的中年样本调查数据(9次中年队列)和5次56天的每日突发；(2)将新的青年队列(18-39)纳入研究(每年评估5年，完成3次56天的数据突发)；以及(3)对一部分受试者(每个队列50人)进行两次为期10天的皮质醇评估(收集3X天)。这将允许评估个体内部变异性的个体间差异以及成年后风险和复原力资源的变化，这些资源导致一些人茁壮成长和健康，另一些人经历有害的身心健康后果。

DESCRIPTION (provided by applicant): This proposal is for a competitive renewal of the Notre Dame Study of Health and Well-being (NDHWB; R01 AG023571) to support an investigation of the myriad pathways through which life stress contributes to the physical and mental health across the adult lifespan, and of the resilience mechanisms that may protect those individuals from the ill-effects of exposure to adversity. The existing data set is unparalleled in the richness of stress measurement, collected over multiple time points spanning 5 years and including 5 annual questionnaire assessments and three 56-day data bursts (Years 1, 3, & 5; two in the midlife cohort). These data allow us to examine multiple forms of adversity, their common and distinctive linkages, with subsequent indicators of health and well-being. With the present proposal, we broaden the study by collecting additional longitudinal data (expanding the study to 10 years), adding 2 additional data bursts to the later life cohort (Years 7 & 9) and 3 bursts in the mid-life cohort (Years 6, 8, & 10). We extend the study by adding a young adult cohort (ages 18 - 40), assessing them with 5 annual questionnaires and 3 data bursts (years 1, 3, & 5) to better understand how these factors are developed and maintained in adulthood. Finally, we propose to add two 10-day bursts of cortisol assessments (collected 3 X day) on a subset of subjects (50 per cohort) to capture physiological responses to stress. The overarching goal of the expanded project is twofold: to comprehensively and precisely detail the types and qualities of life stress that may initiate the cascade of perceptual, emotional, and biological responses that can lead to disorder and disease, and to examine resilience resources that protect against them. PUBLIC HEALTH RELEVANCE: In this competitive renewal, we propose to expand and significantly enhance the Notre Dame Study of Health & Well-Being (NDHWB) by including (1) 5 more years of intensive longitudinal assessments (including 5 yearly assessments and two separate 56-day bursts (three for the midlife), which will culminate in 10 years of survey data for the later life sample (9 for the mid-life cohort) and 5 56-day daily bursts; (2) a new young adult cohort (18-39) to the study (assessed yearly for 5 years and completing 3 56-day data bursts); and (3) two 10-day bursts of cortisol assessments (collected 3 X day) on a subset of subjects (50 from each cohort). This will allow for the assessment of interindividual differences in intraindividual variability and change across the adult lifespan in the risk and resilience resources that lead some to thrive and be well, and others to experience detrimental physical and mental health consequences.