Shared Resource: Laboratory Animal Facility

模型系统共享资源：实验室动物工厂（LAF） 项目概要/摘要 实验动物设施（LAF）允许创建和使用转化动物模型，以促进 癌症中心成员的研究。动物护理计划在FCCC已完全认可， AAALAC国际自1969年以来，并已被授予名誉地位。黎巴嫩武装部队完全遵守 监管机构，包括缉毒局，美国农业部， 实验动物福利办公室在VMD希尔顿克莱因的指导下， LAF管理和技术人员，LAF提供畜牧业和动物支持服务， 癌症中心的成员谁需要老鼠，兔子，青蛙或其他啮齿动物为他们的研究。下 在Jennifer罗兹博士的指导和科学技术人员的支持下，新的斑马鱼服务线正在 现在癌症中心的会员可以使用。斑马鱼是一个理想的模型来发现基因是必不可少的 用于体内造血发育。血细胞类型的谱和已知的调节基因 正常的造血在斑马鱼和哺乳动物之间是很保守的，这表明调节造血的基因是一个重要的基因。 指导谱系特化和分化的机制在脊椎动物物种中是相似的。38 癌症中心成员在2014年使用了LAF。在2014年被占用的鼠笼中，95%支持 科学的研究人员与同行评审的资金。100%的斑马鱼服务的使用是为了支持 2014年同行评审资助的调查人员。在2011-2014年期间，55个癌症患者使用了LAF。 来自所有五个研究项目的中心成员。比较医学研究大楼建成 在最后一个周期，成本为1400万美元。800万美元的ARRA资金与600万美元的机构投资相匹配。 这个新的动物园毗邻现有的LAF大楼，并提供额外的12，511净平方英尺， 动物饲养和程序。FCCC投资765，783美元用于改造和设备，以生产斑马鱼 提供服务。现场集中的LAF具有成本效益，对同行审查、资助的 在FCCC的研究项目。研究动物和动物护理人员随时可供研究者使用 并且可以容易地实现育种、饲养或处理方案的修改， 延迟或误解。尽管一个场外的商业设施可以提供和照顾， FCCC研究动物，研究人员在旅行和运输动物到 将严重损害研究。大多数（90%）批准的动物使用 方案涉及至少每周一次，在某些情况下每天一次，观察，数据或组织收集，由实验室进行。 研究人员。LAF由一个专门的设施咨询委员会（FAC）提供咨询，该委员会至少 每年。FAC的建议直接提交给管理机构母公司监督委员会（FPOC）， 确保LAF继续拥有必要的资源，以提供最高质量的 服务FPOC向高级领导层提交报告。

MODEL SYSTEMS SHARED RESOURCE: LABORATORY ANIMAL FACILITY (LAF) PROJECT SUMMARY/ABSTRACT The Laboratory Animal Facility (LAF) allows the creation and use of translational animal models to facilitate research for Cancer Center members. The animal care program at FCCC has been fully accredited by AAALAC International since 1969 and has been awarded Emeritus status. The LAF is in full compliance with regulatory agencies including the Drug Enforcement Administration, United States Department of Agriculture, and Office of Laboratory Animal Welfare. Under the direction of Hilton Klein, VMD and with the support of 16 LAF management and technical staff, the LAF provides animal husbandry and animal support services for Cancer Center members who require mice, rabbits, frogs or other rodents for their research. Under the direction of Jennifer Rhodes, PhD, and the support of a scientific technician, a new Zebrafish service line is now available to Cancer Center members. Zebrafish are an ideal model to discover genes that are essential for hematopoietic development in vivo. The spectrum of blood cell types and the genes known to regulate normal hematopoiesis are well conserved between zebrafish and mammals, suggesting that the regulatory mechanisms directing lineage specification and differentiation are similar across vertebrate species. 38 Cancer Center members used the LAF in 2014. 95% of the mouse cages occupied in 2014 supported the science of investigators with peer-reviewed funding. 100% of the use of zebrafish services was in support of peer-review funded investigators in 2014. For the period 2011-2014, the LAF was utilized by 55 Cancer Center members from all five Research Programs. A Comparative Medical Research Building was constructed during the last cycle at a cost of $14M. ARRA funds of $8M were matched with institutional investment of $6M. This new vivarium adjoins the existing LAF building and provides an additional 12,511 net square feet for animal housing and procedures. FCCC invested $765,783 in renovations and equipment to make zebrafish services available. An on-site, centralized LAF is cost efficient and critical to the peer-reviewed, funded research programs at FCCC. The research animals and animal care staff are readily available to investigators and modifications in breeding, husbandry, or treatment protocols can be readily accomplished reducing any delay or misinterpretation. Although an off-site commercial facility could conceivably supply and care for FCCC research animals, the inconvenience to the investigators in both travel and transporting animals to and from FCCC would be a serious impairment to research. The majority (90%) of the approved animal use protocols involve at least weekly, in some instances daily, observations, data, or tissue collections by the research staff. The LAF is advised by a dedicated Facility Advisory Committee (FAC) that meets at least annually. FAC recommendations are directed to a governing Facility Parent Oversight Committee (FPOC), which serves to ensure that the LAF continues to have the necessary resources to provide the highest quality services. The FPOC issues reports to senior leadership.