Stromal cell therapy as a treatment against Gastrointestinal Acute Radiation Syndrome (GI-ARS)

摘要 暴露在高剂量电离辐射下会导致多个器官损伤，导致急性辐射 综合症。骨髓移植是一种替代和再生受损干细胞的有效方法。 细胞，它已被证明在减轻辐射引起的急性骨髓损伤(BM- Ars)。然而，在较高的辐射剂量下，对于非造血损伤，单靠骨髓缓解并不是 足以从死亡中拯救出来。例如，急性放射性胃肠道损伤(GI-ARS)是 不能通过骨髓移植或细胞因子疗法缓解。我们已经证明，GI-ARS可以通过以下方式成功缓解 骨髓贴壁基质细胞移植(BMASCT)，主要由基质细胞和髓样细胞组成。 目前形式的BMASCT在大量人群处于危险之中时是有限的，人类白细胞抗原文库和同种异体 细胞移植疗法对于为大量人群开发这种疗法是必不可少的。当前应用程序 提出了各种策略来开发可用于大规模伤亡的放射防护细胞产品 场景。

ABSTRACT Exposure to high doses of ionizing radiation results in injury to multiple organs causing acute radiation syndrome. Bone marrow transplant (BMT) is an effective strategy to replace and regenerate injured stem cells, it has proven to be very successful in mitigating radiation induced acute injury to the bone marrow (BM- ARS). However at higher radiation doses and for non-hematopoietic injuries, BM mitigation alone is not sufficient to rescue from mortality. For instance, acute radiation injury to the gastro-intestinal tract (GI-ARS) is not mitigated by BMT or cytokine therapies. We have shown that GI-ARS can be successfully mitigated by bone marrow adherent stromal cell transplant (BMASCT), consisting mainly of stromal and myeloid cells. BMASCT in its current form is limiting when a large population is at risk, HLA libraries and well as allogeneic cell transplant therapies are essential to developing this therapy for a large population. Current application proposes various strategies to develop a radiomitigating cell product that can be used in a mass casualty scenario.