Use of focused ultrasound to increase melanoma immunogenicity and inhibit tumor-induced T cell tolerance

使用聚焦超声增加黑色素瘤免疫原性并抑制肿瘤诱导的 T 细胞耐受

基本信息

  • 批准号:
    9893711
  • 负责人:
  • 金额:
    $ 38.2万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-04-01 至 2023-03-31
  • 项目状态:
    已结题

项目摘要

Immunosuppressive mechanisms in the tumor microenvironment promote tumor growth by preventing the adaptive immune system from mounting effective antitumor responses. One of the main consequences of the immunosuppressive tumor microenvironment is the induction of tumor antigen-specific T cell tolerance. Overcoming such blockade has remained a major challenge in cancer immunotherapy. Our data show that thermic and physical stress induced by low-intensity focused ultrasound (LOFU) prevents the induction of tumor- antigen specific T cell tolerance and, in combination with ablative therapy, results in improved control of primary melanoma, reduces local recurrence and markedly decreases the occurrence of pulmonary metastases. This represents a new therapeutic approach that by acting locally on tumor cells has the potential to inhibit the establishment of tumor-antigen specific induced T cell tolerance. In this application, our goal is to understand the mechanisms that induce enhanced immunogenic melanoma cell death after LOFU-treatment, determine the potential of using LOFU+ablation as an in-situ melanoma vaccine and finally study whether LOFU can increase efficiency and reduced toxicity when used in combination with checkpoint inhibitors.
肿瘤微环境中的免疫抑制机制通过阻止肿瘤细胞增殖来促进肿瘤生长。 适应性免疫系统从安装有效的抗肿瘤反应。一个主要的后果是, 免疫抑制性肿瘤微环境是肿瘤抗原特异性T细胞耐受的诱导。 克服这种阻断仍然是癌症免疫治疗的主要挑战。我们的数据显示 由低强度聚焦超声(LOFU)诱导的热和物理应力防止了肿瘤的诱导, 抗原特异性T细胞耐受,并与消融治疗组合,导致原发性免疫缺陷综合征的控制改善。 黑色素瘤,减少局部复发,并显着降低肺转移的发生。这 代表了一种新的治疗方法,通过局部作用于肿瘤细胞, 肿瘤抗原特异性诱导T细胞耐受的建立。在这个应用程序中,我们的目标是了解 LOFU治疗后诱导增强的免疫原性黑素瘤细胞死亡的机制决定了 使用LOFU+消融作为原位黑色素瘤疫苗的潜力,并最终研究LOFU是否可以增加 当与检查点抑制剂组合使用时,效率和降低的毒性。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Chandan Guha其他文献

Chandan Guha的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Chandan Guha', 18)}}的其他基金

Understanding stem cell heterogeneity and niche function in intestinal regeneration after irradiation
了解辐射后肠道再生中的干细胞异质性和生态位功能
  • 批准号:
    10910625
  • 财政年份:
    2023
  • 资助金额:
    $ 38.2万
  • 项目类别:
Regeneration of the Immune System after Radiation Exposure
辐射暴露后免疫系统的再生
  • 批准号:
    10686385
  • 财政年份:
    2022
  • 资助金额:
    $ 38.2万
  • 项目类别:
Regeneration of the Immune System after Radiation Exposure
辐射暴露后免疫系统的再生
  • 批准号:
    10474871
  • 财政年份:
    2022
  • 资助金额:
    $ 38.2万
  • 项目类别:
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
碳离子放射治疗胰腺癌的相对免疫有效性(RIE)
  • 批准号:
    10158123
  • 财政年份:
    2021
  • 资助金额:
    $ 38.2万
  • 项目类别:
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
碳离子放射治疗胰腺癌的相对免疫有效性(RIE)
  • 批准号:
    10330035
  • 财政年份:
    2021
  • 资助金额:
    $ 38.2万
  • 项目类别:
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
碳离子放射治疗胰腺癌的相对免疫有效性(RIE)
  • 批准号:
    10544737
  • 财政年份:
    2021
  • 资助金额:
    $ 38.2万
  • 项目类别:
Stromal cell therapy as a treatment against Gastrointestinal Acute Radiation Syndrome (GI-ARS)
基质细胞疗法作为胃肠道急性放射综合症(GI-ARS)的治疗方法
  • 批准号:
    9886178
  • 财政年份:
    2018
  • 资助金额:
    $ 38.2万
  • 项目类别:
Stromal cell therapy as a treatment against Gastrointestinal Acute Radiation Syndrome (GI-ARS)
基质细胞疗法作为胃肠道急性放射综合症(GI-ARS)的治疗方法
  • 批准号:
    10359772
  • 财政年份:
    2018
  • 资助金额:
    $ 38.2万
  • 项目类别:
Use of focused ultrasound to increase melanoma immunogenicity and inhibit tumor-induced T cell tolerance
使用聚焦超声增加黑色素瘤免疫原性并抑制肿瘤诱导的 T 细胞耐受
  • 批准号:
    10365967
  • 财政年份:
    2018
  • 资助金额:
    $ 38.2万
  • 项目类别:
Immune modulation of radiation therapy with Flt3 ligand
Flt3配体对放射治疗的免疫调节
  • 批准号:
    9129622
  • 财政年份:
    2015
  • 资助金额:
    $ 38.2万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 38.2万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 38.2万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 38.2万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 38.2万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 38.2万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 38.2万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 38.2万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 38.2万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 38.2万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 38.2万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了