Neuromodulation of the Brain-Gut Axis by Transcutaneous Vagal Nerve Stimulation in Functional Dyspepsia

功能性消化不良经皮迷走神经刺激对脑肠轴的神经调节

基本信息

  • 批准号:
    9756375
  • 负责人:
  • 金额:
    $ 25.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-08-15 至 2022-07-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT Functional Dyspepsia (FD) is a common functional gastrointestinal disorder that affects millions of Americans every year. Symptoms include recurrent epigastric discomfort consisting of any one or a combination of postprandial fullness, early satiation, and/or epigastric pain or burning, in the absence of a clear structural etiology. Some patients with FD are particularly bothered by postprandial fullness and early satiation, a hallmark of the Postprandial Distress Syndrome (PDS) subtype. These symptoms can be particularly debilitating, leading to impaired daily functioning and decreased quality of life. Despite the negative impact these symptoms have on patients' lives, the pathogenesis of PDS-predominant FD (PDS-FD) is not well understood, although it has been postulated that dysregulation of the brain-gut axis driven by abnormal brainstem vagal neurocircuitry is a possible culprit. The current mainstay of treatment for PDS-FD is pharmacological intervention which is, at best, modestly effective. Moreover, in some severe cases, symptoms become intractable, medication causes unwanted side effects and/or patient becomes treatment resistant. However, given the strong link between FD symptoms and compromised vagal function we propose a non- invasive approach that targets the auricular branch of the vagus nerve via transcutaneous vagal nerve stimulation (tVNS) delivered to the cymba conchae of the external ear. Thus, auricular tVNS may provide a novel therapeutic strategy to modulate aberrant brain-gut signaling in PDS-predominant FD. In the current project, we use gastric/autonomic measures combined with multimodal neuroimaging techniques to interrogate the peripheral and central nervous system changes that accompany neuromodulation of brain-gut axis signaling by auricular tVNS in PDS-FD patients during a prandial challenge. The proposed study will contribute new insights into the pathophysiology underlying PDS-FD as well as evaluate the fidelity of novel, non-invasive neuromodulatory techniques such as auricular tVNS to mitigate FD symptoms.
摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)

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VITALY NAPADOW其他文献

VITALY NAPADOW的其他文献

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{{ truncateString('VITALY NAPADOW', 18)}}的其他基金

Non-invasive assessment and modulation of brain-gut interoception in humans
人类脑肠内感受的无创评估和调节
  • 批准号:
    10591158
  • 财政年份:
    2023
  • 资助金额:
    $ 25.28万
  • 项目类别:
Sex-Dependent Impact of Transcutaneous Vagal Nerve Stimulation on the Stress Response Circuitry and Autonomic Dysregulation in Major Depression
经皮迷走神经刺激对重度抑郁症应激反应回路和自主神经失调的性别依赖性影响
  • 批准号:
    10349464
  • 财政年份:
    2020
  • 资助金额:
    $ 25.28万
  • 项目类别:
Resource Support Core
资源支持核心
  • 批准号:
    10349462
  • 财政年份:
    2020
  • 资助金额:
    $ 25.28万
  • 项目类别:
Sex-Dependent Impact of Transcutaneous Vagal Nerve Stimulation on the Stress Response Circuitry and Autonomic Dysregulation in Major Depression
经皮迷走神经刺激对重度抑郁症应激反应回路和自主神经失调的性别依赖性影响
  • 批准号:
    10540804
  • 财政年份:
    2020
  • 资助金额:
    $ 25.28万
  • 项目类别:
Resource Support Core
资源支持核心
  • 批准号:
    10540793
  • 财政年份:
    2020
  • 资助金额:
    $ 25.28万
  • 项目类别:
Sex-Dependent Impact of Transcutaneous Vagal Nerve Stimulation on the Stress Response Circuitry and Autonomic Dysregulation in Major Depression
经皮迷走神经刺激对重度抑郁症应激反应回路和自主神经失调的性别依赖性影响
  • 批准号:
    10089494
  • 财政年份:
    2020
  • 资助金额:
    $ 25.28万
  • 项目类别:
Resource Support Core
资源支持核心
  • 批准号:
    10089492
  • 财政年份:
    2020
  • 资助金额:
    $ 25.28万
  • 项目类别:
Boosting mind-body mechanisms for mitigating central sensitization in migraine
增强身心机制以减轻偏头痛的中枢敏化
  • 批准号:
    10456008
  • 财政年份:
    2018
  • 资助金额:
    $ 25.28万
  • 项目类别:
Boosting mind-body mechanisms and outcomes for chronic pain
促进慢性疼痛的身心机制和结果
  • 批准号:
    10456004
  • 财政年份:
    2018
  • 资助金额:
    $ 25.28万
  • 项目类别:
Boosting mind-body mechanisms for mitigating central sensitization in migraine
增强身心机制以减轻偏头痛的中枢敏化
  • 批准号:
    10000034
  • 财政年份:
    2018
  • 资助金额:
    $ 25.28万
  • 项目类别:

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