Resource Support Core

资源支持核心

• 批准号: 10540793
• 负责人: VITALY NAPADOW
• 金额: $ 9.8万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540793
• 关键词: 3-Dimensional; Address; Anatomy; Animal Experiments; Animal Model; Animals; Area; Behavioral; Biometry; Blood Vessels; Brain; Brain region; Clinical; Collection; Communities; Consultations; Data; Data Analyses; Data Pooling; Data Set; Databases; Development; Distributed Databases; Ensure; Etiology; Evaluation; Faculty; Fetal Development; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Glean; Heart; Human; Human Resources; Image; Image Analysis; Immune; Individual; Infrastructure; Institution; Intervention; Investigation; Magnetic Resonance Imaging; Major Depressive Disorder; Measurement; Methods; Mission; Modeling; Moods; Nature; Neuroanatomy; Neurobiology; Neurosciences; Noise; Outcome; Pathway interactions; Peripheral; Physiologic pulse; Physiological; Physiology; Rattus; Reproducibility; Research; Research Personnel; Resolution; Resource Sharing; Resources; Rest; Sex Differences; Signal Transduction; Source; Standardization; Stimulus; Stress; System; Techniques; Testing; Therapeutic Intervention; Time; Transdermal substance administration; Translating; United States National Institutes of Health; Vagus nerve structure; Work; analytical tool; attenuation; biological adaptation to stress; biomedical imaging; computerized data processing; data acquisition; data sharing; data structure; database structure; design; experimental study; heart rate variability; human model; interest; mathematical model; middle age; neural; neuroimaging; neuroinformatics; neuroregulation; novel; prenatal stress; respiratory; response; sex; sharing platform; signal processing; synergism; tool; vagus nerve stimulation; web portal

PROJECT SUMMARY The Resource Support Core (RSC) will provide infrastructure and tools to enable a cohesive approach to the collection, analysis, storage and sharing of data across the SCORE projects. The RSC will also provide expert support in areas such as biostatistics, transcutaneous vagus nerve stimulation, and advance autonomic and neuroimaging analyses. Establishing a unified approach enhances the quality of all studies, allowing each project to inform the others in potentially significant ways, and enabling valuable exploratory analyses through the pooling of data collected by multiple projects. The noninvasive nature of MRI allows for multiple experiments on an individual subject, either during the course of one examination period or on multiple occasions, as proposed in the current proposal to accomplish the aims of projects 1 and 2. The imaging data must be registered accurately, in both space and time, and interpreted to isolate physiological phenomena of interest from extraneous noise sources. Three-dimensional, high-resolution, anatomical MRI images will provide the basis for interrelating neuroimaging information. A broad range of functional imaging analytic tools will then be applied to interrogate both resting brain state and task- and/or stimulus-induced regional activation. The image analysis tools we propose have been extensively tested and validated by investigators at the Athinoula A. Martinos Center for Biomedical Imaging, over many years. The RSC will provide access to this broad neuroimaging expertise of the Martinos Center and will deliver a reproducible and efficient means to obtain, analyze, test and correlate structural and functional neuroimaging with physiological data. The RSC will also provide support on biomedical signal processing by developing and executing plans for advanced mathematical modeling and processing of physiological measurements taken in both the animal and human experiments. This will facilitate translational analyses of the mechanisms of autonomic dysregulation explored in projects 1 and 3. Experts on the implementation of non-invasive vagus nerve stimulation techniques in human and animal models have been included in the RSC and will assist in the experimental set up and interpretation of vagal neuromodulation effects on behavioral, imaging and physiological outcomes in projects 2 and 3. Beyond acquisition and analytic support, the RSC is designed to support critical cross-project data analyses. Cross-project synergy is essential to the overall SCORE research plan and built into the design of the projects. This will allow for interesting and potentially valuable pooled analyses of the data and will permit us to address larger-scale questions about sex differences in the neuroscience of the neural pathophysiological mechanisms responsible for autonomic dysregulation in major depression and sex differences in the effects of a novel transcutaneous vagal stimulation technique on the attenuation of these alterations.

项目摘要 资源支持核心（RSC）将提供基础架构和工具，以实现凝聚力的方法 在分数项目中收集，分析，存储和共享数据。 RSC还将为专家提供 在生物统计学，经皮神经刺激以及提高自主神经和提高自主和 神经影像分析。建立统一的方法可以提高所有研究的质量，从而允许每个研究 项目以潜在的重要方式告知其他人，并通过 由多个项目收集的数据汇总。 MRI的无创性允许多个 在一个考试期间或多个检查期间，对个人受试者进行实验 正如当前提出的实现项目目标目标1和2的建议。成像数据 必须在空间和时间上准确注册，并解释为分离的生理现象 多余的噪声来源的兴趣。三维高分辨率，解剖学MRI图像将 提供相互关联神经影像信息的基础。广泛的功能成像分析工具 然后将应用于询问静止的大脑状态和任务和/或刺激引起的区域激活。 我们提出的图像分析工具已由研究人员在 多年来，Athinoula A. Martinos生物医学成像中心。 RSC将提供对此的访问 马提尼斯中心的广泛神经影像学专业知识，并将提供可再现和有效的手段 获得，分析，测试和将结构和功能性神经影像与生理数据相关联。 RSC会 还通过制定和执行高级计划来为生物医学信号处理提供支持 动物和人类进行的生理测量的数学建模和处理 实验。这将有助于探讨自主性失调机制的转化分析 在项目1和3中。 人类和动物模型已包含在RSC中，将有助于实验设置和 解释迷走神经调节对项目行为，成像和生理结果的影响 2和3。除了获得和分析支持之外，RSC旨在支持关键的跨项目数据 分析。横向项目协同作用对于整体得分研究计划至关重要，并内置在设计中 项目。这将允许对数据进行有趣且可能有价值的汇总分析，并将允许 我们要解决有关神经科学中性别差异的大规模问题 病理生理机制负责大抑郁症和性别的自主性失调 新型经皮迷走神经刺激技术对这些衰减的影响的差异 改变。