Resource Support Core

项目摘要 资源支助核心将提供基础设施和工具，以便能够采取协调一致的办法， 在SCORE项目中收集、分析、存储和共享数据。RSC还将提供专家 在生物统计学、经皮迷走神经刺激和先进的自主神经和 神经影像学分析。建立统一的方法可以提高所有研究的质量， 项目以潜在的重要方式通知其他人，并通过以下方式进行有价值的探索性分析： 汇集多个项目收集的数据。MRI的非侵入性性质允许多个 对单个受试者进行的实验，无论是在一个考试期间还是在多个考试期间 根据本提案的建议，在某些情况下，为实现项目1和项目2的目标，成像数据 必须在空间和时间上准确记录，并解释以隔离生理现象， 不受外来噪音干扰。三维，高分辨率，解剖MRI图像将 为神经影像信息的相互关联提供了基础。广泛的功能成像分析工具 然后将被应用于询问静息脑状态和任务和/或刺激诱导的区域激活。 我们提出的图像分析工具已经过研究人员的广泛测试和验证， 阿提努拉湖Martinos生物医学成像中心，多年来。RSC将提供访问此 Martinos中心广泛的神经影像学专业知识，并将提供一种可重复和有效的手段， 获取、分析、测试和关联结构和功能神经成像与生理数据。RSC将 还通过制定和执行先进的生物医学信号处理计划， 对动物和人类的生理测量进行数学建模和处理 实验这将有助于对所探索的自主神经失调机制的翻译分析 在项目1和3中。专家对实施无创迷走神经刺激技术， 人类和动物模型已被纳入RSC，并将有助于实验设置， 迷走神经调节对项目中行为、成像和生理结果的影响的解释 2和3除了采集和分析支持之外，RSC还旨在支持关键的跨项目数据 分析。跨项目的协同作用是必不可少的整体SCORE研究计划，并内置到设计 项目。这将允许对数据进行有趣的和潜在有价值的汇总分析， 我们解决更大规模的问题，性别差异的神经科学的神经 抑郁症自主神经失调的病理生理机制与性别 一种新的经皮迷走神经刺激技术对这些衰减的影响的差异 改变。

PROJECT SUMMARY The Resource Support Core (RSC) will provide infrastructure and tools to enable a cohesive approach to the collection, analysis, storage and sharing of data across the SCORE projects. The RSC will also provide expert support in areas such as biostatistics, transcutaneous vagus nerve stimulation, and advance autonomic and neuroimaging analyses. Establishing a unified approach enhances the quality of all studies, allowing each project to inform the others in potentially significant ways, and enabling valuable exploratory analyses through the pooling of data collected by multiple projects. The noninvasive nature of MRI allows for multiple experiments on an individual subject, either during the course of one examination period or on multiple occasions, as proposed in the current proposal to accomplish the aims of projects 1 and 2. The imaging data must be registered accurately, in both space and time, and interpreted to isolate physiological phenomena of interest from extraneous noise sources. Three-dimensional, high-resolution, anatomical MRI images will provide the basis for interrelating neuroimaging information. A broad range of functional imaging analytic tools will then be applied to interrogate both resting brain state and task- and/or stimulus-induced regional activation. The image analysis tools we propose have been extensively tested and validated by investigators at the Athinoula A. Martinos Center for Biomedical Imaging, over many years. The RSC will provide access to this broad neuroimaging expertise of the Martinos Center and will deliver a reproducible and efficient means to obtain, analyze, test and correlate structural and functional neuroimaging with physiological data. The RSC will also provide support on biomedical signal processing by developing and executing plans for advanced mathematical modeling and processing of physiological measurements taken in both the animal and human experiments. This will facilitate translational analyses of the mechanisms of autonomic dysregulation explored in projects 1 and 3. Experts on the implementation of non-invasive vagus nerve stimulation techniques in human and animal models have been included in the RSC and will assist in the experimental set up and interpretation of vagal neuromodulation effects on behavioral, imaging and physiological outcomes in projects 2 and 3. Beyond acquisition and analytic support, the RSC is designed to support critical cross-project data analyses. Cross-project synergy is essential to the overall SCORE research plan and built into the design of the projects. This will allow for interesting and potentially valuable pooled analyses of the data and will permit us to address larger-scale questions about sex differences in the neuroscience of the neural pathophysiological mechanisms responsible for autonomic dysregulation in major depression and sex differences in the effects of a novel transcutaneous vagal stimulation technique on the attenuation of these alterations.