Resource Support Core

项目总结 资源支持核心(RSC)将提供基础设施和工具，以实现 跨SCORE项目收集、分析、存储和共享数据。皇家莎士比亚剧团还将提供专家 在生物统计学、经皮迷走神经刺激、促进自主神经和 神经影像分析。建立统一的方法可以提高所有研究的质量，允许每项研究 项目以潜在的重要方式通知其他人，并通过 汇集多个项目收集的数据。MRI的非侵入性本质允许 在一次考试期间或在多个考试期间对单个科目进行的实验 为实现项目1和项目2的目标而在本提案中提议的情况。成像数据 必须在空间和时间上准确地记录，并解释以隔离 来自外部噪声源的兴趣。三维、高分辨率、解剖的MRI图像将 为相互关联神经影像信息提供基础。广泛的功能成像分析工具 然后将被应用于询问休息的大脑状态以及任务和/或刺激诱导的区域激活。 我们提出的图像分析工具已经过广泛的测试和验证， 阿蒂努拉·A·马蒂诺斯生物医学成像中心，多年。RSC将提供对此的访问 马蒂诺斯中心广泛的神经成像专业知识，将提供一种可重复和有效的手段 获取、分析、测试并将结构和功能神经成像与生理数据相关联。皇家莎士比亚剧团将 还通过制定和执行高级计划为生物医学信号处理提供支持 动物和人体生理测量的数学建模和处理 实验。这将有助于对探索的自主神经失调机制进行翻译分析。 在项目1和项目3中。非侵入性迷走神经刺激技术在 人类和动物模型已被纳入RSC，并将协助建立和 解释迷走神经调节对项目中行为、成像和生理结果的影响 2和3.除了获取和分析支持之外，RSC还旨在支持关键的跨项目数据 分析。跨项目协同对总体分数研究计划至关重要，并被纳入设计 这些项目。这将允许对数据进行有趣的和潜在有价值的汇集分析，并将允许 美国将解决神经科学中有关性别差异的更大规模问题 重度抑郁症和性别自主神经失调的病理生理机制 一种新的经皮迷走神经刺激技术对这些功能的减弱作用的差异 改装。

PROJECT SUMMARY The Resource Support Core (RSC) will provide infrastructure and tools to enable a cohesive approach to the collection, analysis, storage and sharing of data across the SCORE projects. The RSC will also provide expert support in areas such as biostatistics, transcutaneous vagus nerve stimulation, and advance autonomic and neuroimaging analyses. Establishing a unified approach enhances the quality of all studies, allowing each project to inform the others in potentially significant ways, and enabling valuable exploratory analyses through the pooling of data collected by multiple projects. The noninvasive nature of MRI allows for multiple experiments on an individual subject, either during the course of one examination period or on multiple occasions, as proposed in the current proposal to accomplish the aims of projects 1 and 2. The imaging data must be registered accurately, in both space and time, and interpreted to isolate physiological phenomena of interest from extraneous noise sources. Three-dimensional, high-resolution, anatomical MRI images will provide the basis for interrelating neuroimaging information. A broad range of functional imaging analytic tools will then be applied to interrogate both resting brain state and task- and/or stimulus-induced regional activation. The image analysis tools we propose have been extensively tested and validated by investigators at the Athinoula A. Martinos Center for Biomedical Imaging, over many years. The RSC will provide access to this broad neuroimaging expertise of the Martinos Center and will deliver a reproducible and efficient means to obtain, analyze, test and correlate structural and functional neuroimaging with physiological data. The RSC will also provide support on biomedical signal processing by developing and executing plans for advanced mathematical modeling and processing of physiological measurements taken in both the animal and human experiments. This will facilitate translational analyses of the mechanisms of autonomic dysregulation explored in projects 1 and 3. Experts on the implementation of non-invasive vagus nerve stimulation techniques in human and animal models have been included in the RSC and will assist in the experimental set up and interpretation of vagal neuromodulation effects on behavioral, imaging and physiological outcomes in projects 2 and 3. Beyond acquisition and analytic support, the RSC is designed to support critical cross-project data analyses. Cross-project synergy is essential to the overall SCORE research plan and built into the design of the projects. This will allow for interesting and potentially valuable pooled analyses of the data and will permit us to address larger-scale questions about sex differences in the neuroscience of the neural pathophysiological mechanisms responsible for autonomic dysregulation in major depression and sex differences in the effects of a novel transcutaneous vagal stimulation technique on the attenuation of these alterations.